Coverage survey of mass drug administration for trachoma control in Taura district of Jigawa State Northern Nigeria

Abdullahi Idris; Umar Farouq Ibrahim; Saudat Garba Habib; Roseline Duke

doi:10.18203/2320-6012.ijrms20243350

Authors

Abdullahi Idris Department of Ophthalmology, Rasheed Shekoni Specialist Hospital, Dutse Jigawa State, Nigeria
Umar Farouq Ibrahim Department of Ophthalmology, Aminu Kano Teaching Hospital, Kano, Nigeria
Saudat Garba Habib Department of Ophthalmology, Faculty of Clinical Sciences, College of Health Sciences Bayero University Kano/ Aminu Kano Teaching Hospital, Kano, Nigeria https://orcid.org/0000-0002-0626-6518
Roseline Duke Department of Ophthalmology, University of Calabar Teaching Hospital, Calabar, Nigeria

DOI:

https://doi.org/10.18203/2320-6012.ijrms20243350

Keywords:

Trachoma, MDA, Coverage

Abstract

Background: Trachoma is one of the neglected tropical diseases earmarked for elimination as a public health problem by 2030. Active trachoma-trachomatous inflammation-follicular (TF) is controlled through mass drug administration (MDA) with antibiotics where prevalence of TF exceeds 5% in children 1-9 years, with aim to achieve at least 80% as recommended by WHO. This study aimed to evaluate population-based MDA coverage for trachoma in Taura local government area, Jigawa state and compared it with administrative coverage to ascertain the effectiveness MDA programs.

Methods: A cross-sectional survey using ‘30×7’ cluster random sampling (CRS) technique was carried out in 202 randomly selected households of 30 clusters of Taura local government area of Jigawa state. Administrative coverage was compared with the surveyed coverage rates.

Results: The 1,047 persons received treatment during the MDA, giving a crude surveyed coverage of 69.7% (95% CI 67.4-72.0%). Nine hundred and 34 (89.2%) of those who received the antibiotics reported actual consumption, hence effective coverage of 62.2% (95% CI 59.7-64.8%) and coverage-compliance gap of 7.5%. The administrative coverage was 76.3%. Coverage was significantly higher in adults >15 years (p=0.005), female gender (p=0.043), higher literacy (p≤0.0001), and households’ participation in previous MDA (p≤0.0001).

Conclusions: The findings of this survey were lower than the WHO-recommended coverage rate, thereby posing a threat to the trachoma elimination target. If the MDA programme is to succeed, there is need to explore all factors that are likely to have a potential for increasing MDA coverage of antibiotics for trachoma control in the district.

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References

Flaxman SR, Resnikoff S, Bourne RRA, Peter A, Tasanee B, Maria VC, et al. Global causes of blindness and distance visual impairment 1990-2020: A systematic review and meta-analysis. Lancet Glob Health. 2017;5(12):e1221-34.

Hadfield J, Harris SR, Seth-Smith HMB, Surendra P, Patiyan A, Philip MG, et al. Comprehensive global genome dynamics of Chlamydia trachomatis show ancient diversification followed by contemporary mixing and recent lineage expansion. Genome Res. 2017;27(7):1220-9.

Harris SR, Clarke IN, Seth-Smith HM, Anthony WS, Lesley TC, Peter M, et al. Whole genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing. Nat Genet. 2012;44(4):413-9.

World Health Organization. WHO Alliance for the Global Elimination of Trachoma by 2020: progress report on elimination of trachoma, 2021. Wkly Epidemiol Rec. 2021;96(31):353-64. Available at: https://www.who.int/publications/i/item/who-wer9731-353-364. Accessed on 3 July 2024.

World Health Organization. Ending the Neglect to attain the sustainable development goals: a Road Map for Neglected Tropical Diseases 2021-2030. World Health Organization, 2020. Available at: https://www.who.int/publications/i/item/9789240010352 Accessed on 3 July 2024.

Habtamu, E. Wondie T, Aweke S, Zerihun T, Mulat Z, Zebideru Z, et al. Trachoma and relative poverty: a case-control study. PLoS Negl. Trop. Dis. 2015;9(11):e0004228.

Barenfanger J. Studies on the role of the family unit in the transmission of trachoma. Am J Trop Med Hyg. 1975;24(3):509-15.

Solomon AW, Zondervan M, Kuper H, et al. Trachoma control: a guide for programme managers. Geneva: World Health Organization. 2006. Available at: https://www.who.int/publications/i/item/924154 6905 Accessed on 3 July 2024.

World Health Organization. Global elimination of blinding trachoma. Resolution WHA 51.11. Adopted by the World Health Assembly. 1998. Available at: https://www.who.int/publications/i/item/wha51.1 Accessed on 3 July 2024.

Zithromax management guide. How to successfully apply for, administer and manage the Zithromax. 2019. Available at: https://www.trachoma.org/sites/ default/files/2020-10/ITI_ZMG_ENG_102620_ Online.pdf. Accessed on 12 September 2024.

Lietman TM, Porco TC, Dawson C, Blower S. Global elimination of trachoma: how frequently should we administer mass chemotherapy? Nature Med. 1999;5(5):572-6.

Sheila K, West SK, Munoz B, Mkocha H, Gaydos CA, Quinn TC. Number of Years of Annual Mass Treatment with Azithromycin Needed to Control Trachoma in Hyper-Endemic Communities in Tanzania. J Infect Dis. 2011;204(2):268-73.

Burton MJ, Holland MJ, Makalo P, Aryee EA, Alexander ND, Sillah A, et al. Re-emergence of Chlamydia trachomatis infection after mass antibiotic treatment of a trachoma-endemic Gambian community: a longitudinal study. Lancet. 2005;365(9467):1321-8.

World health organization. Status of elimination of trachoma as a public health problem, 2022. WHO. Available at: https://www.trachomaatlas.org. Accessed on 12 September 2024.

Mansur R, Muhammad N, Liman IR. Prevalence and magnitude of trachoma in a local government area of Sokoto State, north western Nigeria. Niger J Med. 2007;16(4):348-53.

Mpyet C, Ogoshi C, Goyol M. Prevalence of trachoma in Yobe State, north-eastern Nigeria. Ophthalmic Epidemiol. 2008;15(5):303-7.

Jip NF, King JD, Diallo MO, Miri ES, Hamza AT, Ngondi J, et al. Blinding Trachoma in Katsina State, Nigeria: Population-Based Prevalence Survey in Ten Local Government Areas. Ophthalmic Epidemiol. 2008;15(5):294-302.

Alice R, Wade P, Ogoshi C, Goyol M, Adenuga O, Dami N, et al. Prevalence of Trachoma in Jigawa State, Northwestern Nigeria. Ophthalmic Epidemiol. 2015;22(3):184-9.

Report obtained from Ministry of Health, Jigawa state. 2015

Population census of the Federal Republic of Nigeria: Analytical report at the national level. Abuja: National Population Commission.

Kasiulevicius V, Sapoka V, Filipaviciute R. Sample size calculation in epidemiological studies. Gerontology. 2006;7:225-31.

WHO. Training for mid-level managers: the EPI coverage survey. Geneva: World Health Organization. 1991. Available at: https://www.who.int/publications/i/item/module-7-the-epi-coverage-survey Accessed on 3 July 2024.

Cromwell EA, King JD, McPherson S, Jip FN, Patterson AE, Mosher AW, et al. Monitoring of Mass Distribution Interventions for Trachoma in Plateau State, Nigeria. PLoS Negl Trop Dis. 2013;7(1):e1995.

Desmond N, Solomon AW, Massae PA, Lema N, Anemona A, Foster A, et al. Acceptability of azithromycin for the control of trachoma in Northern Tanzania. Trans R Socie Trop Mede Hyg. 2005;99(9):656-63.

Mabey DC, Solomon AW, Foster A. Trachoma. Lancet 2003;362(9376):223-9.

Thylefors B, Dawson CR, Jones BR, West SK, Taylor HR. A simple system for the assessment of trachoma and its complications. Bull World Health Organ. 1987;65(4):477-83.