A rare case of non-typhi salmonella meningitis in an immunocompetent adult: a case study

Moinuddin Sunnan; Bhalala Priyank Batukbhai; Fenilkumar Nitinbhai Ribadiya; Mehul Hitesh Sadadiwala

doi:10.18203/2320-6012.ijrms20243383

Authors

Moinuddin Sunnan Gottlied Memorial Hospital, Melrose Park, Illinois
Bhalala Priyank Batukbhai ASPIRE, Department of Internal Medicine, Grodno State Medical University, Grodno, Belarus
Fenilkumar Nitinbhai Ribadiya ASPIRE, Department of Internal Medicine, Grodno State Medical University, Grodno, Belarus
Mehul Hitesh Sadadiwala ASPIRE, Department of Internal Medicine, Grodno State Medical University, Grodno, Belarus

DOI:

https://doi.org/10.18203/2320-6012.ijrms20243383

Keywords:

Salmonella meningitis, NTS, Non-typhi salmonella, Non-typhi salmonella meningitis, Non-typhoidal Salmonella, Guinea pig

Abstract

Salmonella, a gram-negative motile bacillus, is commonly associated with typhoid fever, septicemia, and diarrhea. Non-typhi Salmonella (NTS) can cause bacteremia, meningitis, focal septic infections, pneumonia, and osteomyelitis, although NTS meningitis is rarely reported in immunocompetent adults and is more common in immunocompromised patients, infants, and children. NTS infections are typically transmitted through contaminated food or water, and clinical presentations often lack specific symptoms, making diagnosis challenging. Due to the higher mortality rates, aggressive management with proper antibiotic susceptibility testing is advised. The risk of antibiotic resistance, recurrence, and the invasive nature of the infection make early diagnosis and treatment crucial. The treatment approach should be guided by performing proper antibiotic sensitivity testing. The higher risk of complications, including hydrocephalus, seizures, and empyema, highlights the importance of close follow-up. We describe a case of NTS meningitis that possibly occurred after the consumption of guinea pig meat, where early presentation and appropriate management led to a favorable outcome without progression to further complications.

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References

Keusch GT. Salmonellosis. In: Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, et al. Editors. Harrison’s Principles of Internal Medicine. 14th Ed. New York: McGraw-Hill. 1998:950–6.

Ramakrishnan M. Salmonella typhimurium meningitis in infancy. Ind J Crit Care Med. 2013;17(6):392-3.

Hannan S, Sohail AA. Successfully treated case of non-typhoidal salmonella meningitis in an otherwise healthy 5 months old infant: A Case Report. Asian J Pediat Res. 2019:1-6.

Crump JA, Sjölund-Karlsson M, Gordon MA, Parry CM. Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive salmonella infections. Clin Microbiol Rev. 2015;28(4):901-37.

Stanaway JD, Parisi A, Sarkar K, Brigette F Blacker, Robert C Reiner, Simon I Hay, et al. The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Infect Dis. 2019;19(12):1312-24.

Keddy KH, Sooka A, Musekiwa A, Anthony M Smith, Husna Ismail, Nomsa P Tau, et al. Clinical and microbiological features of salmonella meningitis in a south African population, 2003–2013. Clin Infect Dis. 2015;61(4):272-82.

Aserkoff B, Schroeder SA, Brachman PS. Salmonellosis in the United States-a five-year review1. Am J Epidemiol. 1970;92(1):13-24.

Chen HM, Wang Y, Su LH, Chiu CH. Nontyphoid Salmonella Infection: Microbiology, Clinical Features, and Antimicrobial Therapy. Pediatr Neonatol. 2013;54(3):147-52.

Kauffman CA. Salmonella Meningitis. Arch Neurol. 1979;36(9):578.

Cherubin CE, Marr JS, Sierra MF, Becker S. Listeria and gram-negative bacillary meningitis in New York City, 1972–1979. Am J Med. 1981;71(2):199-209.

Nwadike VU, Fowotade A, Tuta KE, Olusanya OO. A rare case of salmonella typhi meningitis in an eleven-month-old infant: a case report. Ann Ib Postgrad Med. 2012;10(1):38-9.

Price EH. Antibiotics for Salmonella meningitis in children. J Antimicro Chemo. 2000;46(5):653-5.

Karim M, Islam N. Salmonella Meningitis: Report of three cases in adults and literature review. Infection. 2002;30(2):104-8.

Bhutta ZA, Farooqui BJ, Sturm AW. Eradication of a multiple drug-resistant Salmonella paratyphi A causing meningitis with ciprofloxacin. Journal of Infection. 1992;25(2):215-9.

Patrik Gille-Johnson JK. Salmonella Virchow Meningitis in an Adult. Scand J Infect Dis. 2000;32(4):431-3.

Wu HM, Huang WY, Lee ML, Yang AD, Chaou KP, Hsieh LY. Clinical features, acute complications, and outcome of Salmonella meningitis in children under one year of age in Taiwan. BMC Infect Dis. 2011;11(1):30.