Platelet/albumin ratio and plateletcrit levels are potential new biomarkers for assessing acute myocardial infarction: hospital based cross sectional study

Authors

  • Prasad G. Ugaragol Department of General Medicine, S. Nijalingappa Medical College and HSK Hospital and Research Centre, Bagalkot, Karnataka, India
  • Naveen V. Charantimath Department of General Medicine, S. Nijalingappa Medical College and HSK Hospital and Research Centre, Bagalkot, Karnataka, India
  • S. J. Sanketh Department of General Medicine, S. Nijalingappa Medical College and HSK Hospital and Research Centre, Bagalkot, Karnataka, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20243369

Keywords:

Plateletcrit, Acute myocardial infarction, Biomarker, Diagnosis, Platelet/albumin ratio

Abstract

Background: Platelet activation plays a key role in acute myocardial infarction (AMI). Plateletcrit and platelet/albumin ratio are potential new biomarkers, but their diagnostic accuracy for AMI is unclear.

Methods: This was a hospital-based cross-sectional study on 90 patients- 45 with AMI, 45 with unstable angina (UA). Plateletcrit and platelet/albumin ratio were compared between groups and ROC analysis was done to determine predictive accuracy for AMI.

Results: Plateletcrit (0.49±0.04 versus 0.35±0.03, p<0.001) and platelet/albumin ratio (0.85±0.12 versus 0.65±0.09, p<0.001) were significantly higher in the AMI group compared to UA group. At a cutoff of 0.42, plateletcrit had 92% sensitivity and 89% specificity for diagnosing AMI. Platelet/albumin ratio >0.72 differentiated AMI from UA with 82% sensitivity and 84% specificity.

Conclusions: Plateletcrit and platelet/albumin ratio were significantly elevated in AMI compared to UA patients. These biomarkers demonstrated good diagnostic accuracy for detecting AMI at admission. Further large-scale studies are warranted to validate these findings before incorporating into clinical practice.

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Published

2024-10-30

How to Cite

Ugaragol, P. G., Charantimath, N. V., & Sanketh, S. J. (2024). Platelet/albumin ratio and plateletcrit levels are potential new biomarkers for assessing acute myocardial infarction: hospital based cross sectional study. International Journal of Research in Medical Sciences, 12(11), 4180–4184. https://doi.org/10.18203/2320-6012.ijrms20243369

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Original Research Articles