Malignant melanotic nerve sheath tumour of chest wall: a rare and diagnostically challenging case

Authors

  • Sumaira Qayoom Department of Pathology, King George’s Medical University, Lucknow, UP, India
  • Divya Goel Department of Pathology, King George’s Medical University, Lucknow, UP, India
  • Riddhi Jaiswal Department of Pathology, King George’s Medical University, Lucknow, UP, India
  • Naseem Akhtar Department of Surgical Oncology, King George’s Medical University, Lucknow, UP, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20243404

Keywords:

Melanotic, Nerve sheath tumour, BRAFV600E

Abstract

Malignant melanotic nerve sheath tumour (MMNST), previously known as melanotic schwannomas (MS) comprise less than 1% of nerve sheath tumors and around 200 cases have been reported in the literature. According to the WHO 5th edition, it is now classified as malignant neoplasm due to its local recurrence rate and metastatic risk. Although it is classified as malignant, the histopathological criteria for malignancy and prognostic factors remain ill-defined due to its rarity. It also poses a diagnostic challenge as it resembles closely other benign as well as malignant melanin producing tumors. We report here a case of 33 year old female who presented with chest wall swelling and was diagnosed as MS (now classified as MMNST) on histopathology and immunohistochemistry. This case highlights the diagnostic difficulties and the importance of careful histological evaluation and long-term follow-up.

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Published

2024-10-30

How to Cite

Qayoom, S., Goel, D., Jaiswal, R., & Akhtar , N. (2024). Malignant melanotic nerve sheath tumour of chest wall: a rare and diagnostically challenging case. International Journal of Research in Medical Sciences, 12(11), 4356–4359. https://doi.org/10.18203/2320-6012.ijrms20243404

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Section

Case Reports