Multiple fixed drug eruptions

Abstract

Fixed drug eruptions (FDE) are a type of hypersensitivity reaction that occurs in response to certain medications, typically reappearing at the same site when the causative drug is reintroduced. These lesions may present as itchy, red patches, and, less commonly, painful hyperpigmented macules. FDE accounts for a small percentage of all drug reactions and can occur alongside other drug-induced conditions. This case report discusses a 25-year-old female with a history of FDE following the use of norfloxacin and tinidazole for burning micturition and abdominal pain. The patient exhibited well-defined erythematous patches, some associated with previous drug reactions. Discontinuation of the offending drugs and appropriate treatment led to the resolution of her FDE without the appearance of new lesions. Such cases emphasize the importance of early diagnosis and management of FDE in patients with a history of drug-induced skin reactions.