Gastrointestinal function and quality of life in postoperative patients of pancreatoduodenectomy

Veronica Masabanda Celorio; Luis Arturo Chavez Balanza; José Luis Martínez Ordaz; Elda Victoria Rodríguez Negrete; Karina Sanchez Reyes

doi:10.18203/2320-6012.ijrms20244134

Authors

Veronica Masabanda Celorio Department of General and Gastrointestinal Surgery, Department of Gastroenterology and Pancreas Clinic, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico
Luis Arturo Chavez Balanza Department of General and Gastrointestinal Surgery, Department of Gastroenterology and Pancreas Clinic, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico
José Luis Martínez Ordaz Department of General and Gastrointestinal Surgery, Department of Gastroenterology and Pancreas Clinic, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico
Elda Victoria Rodríguez Negrete Department of General and Gastrointestinal Surgery, Department of Gastroenterology and Pancreas Clinic, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico
Karina Sanchez Reyes Department of General and Gastrointestinal Surgery, Department of Gastroenterology and Pancreas Clinic, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Mexico City, Mexico https://orcid.org/0000-0002-2760-3173

DOI:

https://doi.org/10.18203/2320-6012.ijrms20244134

Keywords:

Pancreaticoduodenectomy, Pancreatic cancer, Quality of life, Gastrointestinal function

Abstract

Pancreaticoduodenectomy (PD) is a complex, high-risk procedure with insufficient data on long-term quality of life and gastrointestinal function. Therefore, it is necessary to determine the level of quality of life and functional outcomes in these patients. In the following study, we present a case series analysis, establishing a direct relationship between post-surgical evolution and its impact on quality of life and gastrointestinal function, using two questionnaires: Short Form 36 and Gastrointestinal Symptom Rating Scale. Out of 15 patients the prevalence of pancreaticoduodenectomy in women was 69%, with a mean age of 53 years. The average follow-up period was 3.47 years. When applying the Short Form 36, they rated their general health at 68.67 points, emotional well-being at 78 points, and social well-being at 73 points. Regarding the Gastrointestinal Symptom Rating Scale, 100% reported pain and indigestion, some experienced gastroesophageal reflux, diarrhea, steatorrhea, and constipation; none of these symptoms limited daily life. Patients undergoing pancreaticoduodenectomy experience changes in their quality of life; likewise, gastrointestinal function alterations are common. Those who survive the underlying pathology and PD have quality of life and gastrointestinal function close to normal values, with improvements possible through symptom treatment, psychological support, social assistance, and physical rehabilitation.

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References

Chan C, Franssen B, Domínguez I. Impact on quality of life after pancreatoduodenectomy: a prospective study comparing preoperative and postoperative scores. J Gastrointest Surg. 2012;16(7):1341-6.

Allen C, Yakoub D, Macedo F. Long-term quality of life and gastrointestinal functional outcomes after pancreaticoduodenectomy. Ann Surg. 2018;268(4):657-64.

Huang J, Yeo C, Sohn T. Quality of life and outcomes after pancreaticoduodenectomy. Ann Surg. 2000;231(6):890-8.

Dasari B, Farid S, Roberts K. Overview of pancreatic resections: postoperative management. Br J Hosp Med (Lond). 2015;76(4):60-3.

Arvaniti M, Danias N, Igoumenidis M, Smyrniotis V, Tsounis A, Sarafis P. Comparison of Quality of Life before and after pancreaticoduodenectomy: a prospective study. Electron Physician. 2018;10(7):7054-62.

Andersson T, Falk K, Bjerså K, Forsberg A. Health Is belonging: lived experiences during recovery after pancreaticoduodenectomy. ISRN Nurs. 2012;1:602323.

Distler M, Rückert F, Hunger M, et al. Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma. BMC Surg. 2013;13:12.

Medrano R, Luna M, Chable W. Morbimortalidad de la pancreatoduodenectomía en pacientes con cáncer de páncreas y tumores periampulares en el Hospital de Oncología del Centro Médico Nacional Siglo XXI de 2008 a 2013. Cirugía y cirujanos. 2019;87:69-78.

Arvaniti M, Danias N, Theodosopoulou E, Smyrniotis V, Karaoglou M, Sarafis P. Quality of Life Variables Assessment, Before and After Pancreatoduodenectomy (PD): Prospective Study. Glob J Health Sci. 2015;8(6):203-10.

Targarona J, Callacondo D, Pino C. Impacto de la duodenopancreatectomía en los pacientes adultos mayores. Rev. gastroenterol. Perú. 2013;3:217-22.

Heerkens H, Van Berkel L, Tseng D. Long-term health-related quality of life after pancreatic resection for malignancy in patients with and without severe postoperative complications. HPB. 2018;20(2):188-95.

Rückert F, Distler M, Hoffmann S. Quality of life in patients after pancreaticoduodenectomy for chronic pancreatitis. J Gastrointest Surg. 2011;15(7):1143-50.

McLeod R. Quality of life, nutritional status and gastrointestinal hormone profile following the Whipple procedure. Ann Oncol. 1999;10(4):281-4.

Scholten L, Stoop TF, Del Chiaro M. Systematic review of functional outcome and quality of life after total pancreatectomy. Br J Surg. 2019;106(13):1735-46.

Van Dijk S, Heerkens H, Tseng D. Systematic review on the impact of pancreatoduodenectomy on quality of life in patients with pancreatic cancer. HPB (Oxford). 2018;20(3):204-15.