Evaluation of cardiopulmonary function and health outcomes among petrol pump attendants in Lucknow district

Authors

  • Hari Singh Department of Physiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India
  • Seema Singh Department of Physiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India
  • Syed T. Raza Department of Physiology, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20243720

Keywords:

Petrol pump attendants, Occupational health, Gasoline fumes, Lung function, Cardiovascular function

Abstract

Background: Petrol pump attendants face heightened health risks due to prolonged exposure to gasoline fumes, which contain harmful chemicals like benzene and particulate matter. This community is generally neglected regarding their health. This study investigates the impact of such occupational exposure on the lung and cardiovascular functions of petrol pump workers in Lucknow, India.

Methods: A case-control study of 80 petrol pump workers and 80 healthy controls in Lucknow measured physical and physiological parameters, including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), mean arterial pressure (MAP), pulse rate, and peak expiratory flow rate (PEFR). Analysis utilized independent t-tests and receiver operating characteristic (ROC) curve analysis.

Results: Petrol pump workers exhibited significantly higher SBP (126.7 mmHg versus 113.2 mmHg, p<0.001), DBP (81.2 mmHg versus 72.3 mmHg, p<0.001), PP (45.4 mmHg versus 41.0 mmHg, p=0.007), MAP (96.1 mmHg versus 85.3 mmHg, p<0.001), and pulse rate (85.4 bpm versus 72.5 bpm, p<0.001) compared to controls. PEFR was significantly lower in petrol pump workers (365.3 l/min versus 478.9 l/min, p<0.001), indicating reduced lung function. ROC curve analysis demonstrated high diagnostic accuracy for PEFR (AUC=0.84) and pulse rate (AUC=0.88) in distinguishing between cases and controls.

Conclusions: Petrol pump workers in Lucknow exhibit significantly impaired lung function and elevated cardiovascular parameters, likely due to prolonged exposure to gasoline fumes. These findings underscore the need for improved protective measures and health monitoring for this occupational group.

Metrics

Metrics Loading ...

References

Weinberg RA. The Biology of Cancer. 2nd Edition. W. W. Norton & Company. 2013.

National Institute of Cancer Research & Hospital, Hospital Cancer Registry Report 2015-2017. Mohakhali, Dhaka. Available at: https://nicrh.gov. bd/images/reports/5bd09-hbcr-2015-2017. Accessed on 12 September 2024.

National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines Oncology. 2020. Available at: www.nccn.org/professionals/physician _gls/default.aspx. Accessed on 12 September 2024.

Pignon JP, Le Maitre A, Maillard E, Bourhis J; MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomized trials and 17,346 patients. Radiother Oncol. 2009;92(1):4-14.

Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, et al. A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol. 1998;46(2):135-46.

Forastiere AA, Shank D, Neuberg D, Taylor SG 4th, DeConti RC, Adams G. Final report of a phase II evaluation of paclitaxel in patients with advanced squamous cell carcinoma of the head and neck: an Eastern Cooperative Oncology Group trial (PA390). Cancer. 1998;82(11):2270-4.

Schrijvers D, Vermorken JB. Role of taxoids in head and neck cancer. Oncologist. 2000;5(3):199-208.

Citrin D, Mansueti J, Likhacheva A, Sciuto L, Albert PS, Rudy SF, et al. Long-term outcomes and toxicity of concurrent paclitaxel and radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;74(4):1040-6.

Pradier O, Laurent D, Schmidberger H, Rave-Fränk M, Rubisch K, Krebeck M, et al. In vitro study of a paclitaxel-radiotherapy combination on a human epidermoid tumor cell line. Cancer Radiother. 1999;3(1):51-6.

Smith RE, Thornton DE, Allen J. A phase II trial of Paclitaxel in squamous cell carcinoma of the head and neck with correlative laboratory studies. Semin Oncol. 1995;22(3):41-46.

Posner MR, Haddad RI, Wirth L, Norris CM, Goguen LA, Mahadevan A, et al. Induction chemotherapy in locally advanced squamous cell cancer of the head and neck: evolution of the sequential treatment approach. Semin Oncol. 2004;31(6):778-85.

Bari MA, Alam S, Sharmin S, Nahar S, Uddin J, Aslam N. Outcome of Concurrent Chemoradiotherapy and Radiotherapy Alone Following Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck. Bangl Med Res Council Bull. 2018;44(2):93-7.

Posner MR, Haddad RI, Wirth L, Norris CM, Goguen LA, Mahadevan A, et al. Induction chemotherapy in locally advanced squamous cell cancer of the head and neck: evolution of the sequential treatment approach. Semin Oncol. 2004;31(6):778-85.

Das TK, Chatterjee K, Das S et al. 2020. A prospective comparative study. International Journal of Medical Science Public Health 9(1):97-100.

Kanotra SP, Kanotra S, Gupta A. Chemoradiation in advanced head and neck cancers: a comparison of two radiosensitizers, Paclitaxel and Cisplatin. Indian J Otolaryngol Head Neck Surg. 2011;63(3):229-36.

Drau HK, Devi YS, Singh LJ. A study of weekly paclitaxel vs weekly cisplatin with concomitant chemoradiation in locally advanced head and neck cancer. Int J Res Med Sci. 2017;5(11):4895-902.

Jain RK, Kirar P, Gupta G, Dubey S, Gupta SK, Goyal J. A comparative study of low dose weekly paclitaxel versus cisplatin with concurrent radiation in the treatment of locally advanced head and neck cancers. Indian J Cancer. 2009;46(1):50-3.

Downloads

Published

2024-11-30

How to Cite

Singh, H., Singh, S., & Raza, S. T. (2024). Evaluation of cardiopulmonary function and health outcomes among petrol pump attendants in Lucknow district. International Journal of Research in Medical Sciences, 12(12), 4643–4648. https://doi.org/10.18203/2320-6012.ijrms20243720

Issue

Section

Original Research Articles