Neuroendocrine tumour of a larynx in 70-year-old man: a rare entity and a diagnostic challenge

Nida Shabbir; Ajay K. Singh; Manish Chandra; Sumaira Qayoom

doi:10.18203/2320-6012.ijrms20244146

Authors

Nida Shabbir Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Ajay K. Singh Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Manish Chandra Department of Otolaryngology, King George’s Medical University, Lucknow, Uttar Pradesh, India
Sumaira Qayoom Department of Pathology, King George’s Medical University, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20244146

Keywords:

Immunohistochemistry, Larynx, Neuroendocrine tumor, Typical carcinoid

Abstract

Neuroendocrine tumours of the larynx are rare yet neuroendocrine tumors is the second most common larynx tumour. According to the World Health Organization (WHO) 2022 classification, neuroendocrine tumours (NET) can be classified into well-differentiated, moderately differentiated and poorly differentiated. Well-differentiated NETs (typical carcinoids) of the larynx are rare and largely published as case reports. We present a case of a 70-year-old male with a history of hoarseness of voice for 1 year. Grossly, the tumour was globular and encapsulated. Based on histopathological features and immunohistochemistry results, the final diagnosis of a well-differentiated Neuroendocrine tumour was rendered. For carcinoid tumours of the larynx, conservative surgical resection is the preferred treatment without elective neck dissection. This tumour has a favourable prognosis, rare recurrences, and minimal metastasis.

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