Prevalence of crystalluria and its association with Escherichia coli urinary tract infections

Nagarajan Prabhu, Syed Mubarak Mohamed Marzuk, Sivasubramanian Priya Banthavi, Arumugam Sundhararajan, Alagappan Uma, Venkatesan Sarada


Background: Some studies highlighted that there was increase in the incidence of urinary tract problems related to frequent Urinary Tract Infections (UTIs) and crystalluria. This induces us to understand the prevalence of crystals in urine samples and its association with bacterial urinary tract infections. For determining the different types of urinary crystals, the role of microscopic examination for identification are routine and identical.

Methods: The main objective of this study is to find out the predominant types of crystals in urine, age and sex incidence value, urine pH correlated with crystals and bacteriological examination of urine samples associated with UTIs.   

Results: Among 88 urine samples included, 49 (55.6%) were males and 39 (44.3%) were females of different age groups. By urine sediment analysis, among the normal crystals, calcium oxalate and amorphous urates were found predominant followed by cholesterol found among abnormal crystals. The results highlighted the presence of different types of crystals in the urine samples and strongly supported the pH ranges. The variations in the pH range from 3 to 7. The correlation of the results of crystal formation with bacterial culture showed predominance of Escherichia coli (19.3%) and further it gets proved with the theory and reference interpretation.

Conclusion: By this study, the authors have a mystery whether the crystal formation leads to the bacterial infection or the infection leads to crystal formation. In the case of positive urine crystal analysis, the clinicians may consider the microbiological investigations to find out the real picture.  



Crystalluria, Prevalence, Escherichia coli, Calcium oxalate, Amorphous urates

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