Correlation of serum lipid profile and diabetic retinopathy: a prospective study
DOI:
https://doi.org/10.18203/2320-6012.ijrms20250241Keywords:
Hyperlipidemia, Diabetes, Diabetic macular edemaAbstract
Background: To correlate serum lipid levels and presence of Diabetic Macular edema in diabetic retinopathy patients. To compare the serum lipid profile of patients with and without Diabetic Macular edema. To compare and analyze the present study with reference to other studies on serum lipid profile in diabetic retinopathy. To emphasize the importance of doing serum lipid profile as routine investigation in patients with diabetic retinopathy and to initiate treatment for those appropriate.
Methods: A prospective cross-sectional study conducted at Tertiary Eye Care Centre, Salem, TamilNadu with petients presenting to Retina clinic for 6 months with a sample size of 186.
Results: The data analysis was performed using statistical software package SPSS version 22.0. Both the descriptive and inferential statistics were used. The continuous variables were summarized as mean with standard deviation. The categorical variables were summarized as frequencies and proportions.
The comparison of continuous variables was done using unpaired ‘t’ test and comparison of categorical variables were done using Chi square test or Fisher’s exact test depending on distribution. P value of less than 0.05 was considered significant.
Conclusions: The present study gives good evidence of a significant correlation between higher levels of total cholesterol, LDL-C, HbA1C and lower levels of HDL-C with the presence of Diabetic Macular edema. Hence along with diabetes control drugs, lipid lowering drugs should be started for diabetic patients having dyslipidemia.
Metrics
References
Chan M, et al. Global report on diabetes. World Health Organization. 2016;58(12):1-88.
Williams et al. summary, IDF Diabetes Atlas, 2019 (9) : 4
The Diabetes Control and Complications Trial Research Group. Clustering of long-term complications in families with diabetes in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group. Diabetes. 1997;46(11):1829–1839. DOI: https://doi.org/10.2337/diabetes.46.11.1829
Rema M, Saravanan G, Deepa R, Mohan V. Familial clustering of diabetic retinopathy in South Indian Type 2 diabetic patients. Diabet Med. 2002;19(11):910–916. DOI: https://doi.org/10.1046/j.1464-5491.2002.00820.x
5.Klein BE, Moss SE, Klein R, et al. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate. Ophthalmology. 1991;98:1261–1265 DOI: https://doi.org/10.1016/S0161-6420(91)32145-6
World Health Organization [WHO] Country Profile: India 2016.
Vashist P, Senjam SS, Gupta V, Manna S, Gupta N, Shamanna BR, Bhardwaj A, Kumar A, Gupta P. Prevalence of diabetic retinopahty in India: Results from the National Survey 2015-19. Ind J Ophthalmol. 2021;69(11):3087-94. DOI: https://doi.org/10.4103/ijo.IJO_1310_21
Gadkari SS, Maskati QB, Nayak BK. Prevalence of diabetic retinopathy in India: The all-India ophthalmological society diabetic retinopathy eye screening study 2014. Ind J Ophthalmol. 2016;64(1):38-44. DOI: https://doi.org/10.4103/0301-4738.178144
Cheung. Diabetic retinopathy. The Lancet. 2010;376(9735):124-36. DOI: https://doi.org/10.1016/S0140-6736(09)62124-3
Kulkarni S, Ramachandran R, Sivaprasad S, Rani PK, Behera UC, Vignesh TP, et al. Impact of treatment of diabetic macular edema on visual impairment in people with diabetes mellitus in India. Ind J Ophthalmol. 2021;69(3):671-6. DOI: https://doi.org/10.4103/ijo.IJO_2614_20
Mohan V. Investigative ophthalmology and visual science. Prevalence of diabetic retinopathy in urban India. CURES. 2005;46:2328-33. DOI: https://doi.org/10.1167/iovs.05-0019
Acan D. The prevalence and systemic risk factors of diabetic macular edema: a cross-sectional study from Turkey. BMC Ophthalmol. 2018;18:91. DOI: https://doi.org/10.1186/s12886-018-0753-y
Ferris F. Early photocoagulation in patients with either type I or type II diabetes. Trans Am Ophthalmol Soc. 1996;94:505–37.
Sagolsem N, Shah JS, Tulasi RY. Study of Severity of Diabetic Retinopathy with Duration of Type 2 Diabetes Mellitus. Int J Med Sci Clin Res Stu. 2023;3(1):127-32. DOI: https://doi.org/10.47191/ijmscrs/v3-i1-26
Zander E, Herfurth S, Bohl B, et al Maculopathy in patients with diabetes mellitus type 1 and type 2: associations with risk factors. British J Ophthalmol. 2000;84:871-6. DOI: https://doi.org/10.1136/bjo.84.8.871
Arthur E, Young SB, Elsner AE, Baskaran K, Papay JA, Muller MS, et al. Central Macular Thickness in Diabetic Patients: A Sex-based Analysis. Optom Vis Sci. 2019;96(4):266-75. DOI: https://doi.org/10.1097/OPX.0000000000001363
Varma R, Bressler NM, Doan QV, Gleeson M, Danese M, Bower JK, et al. Prevalence of and risk factors for diabetic macular edema in the United States. JAMA Ophthalmol. 2014;132(11):1334-40. DOI: https://doi.org/10.1001/jamaophthalmol.2014.2854
Klein R, Klein BE, Moss SE. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XVI. The relationship of C-peptide to the incidence and progression of diabetic retinopathy. Diabetes. 1995;44(7):796-801. DOI: https://doi.org/10.2337/diabetes.44.7.796
Das R. American academy of ophthalmology. Dyslipidemia and Diabetic Macular Edema. 2015;122(9):1820-7. DOI: https://doi.org/10.1016/j.ophtha.2015.05.011
Chung YR, Park SW, Choi SY. Association of statin use and hypertriglyceridemia with diabetic macular edema in patients with type 2 diabetes and diabetic retinopathy. Cardiovasc Diabetol. 2017;4:16. DOI: https://doi.org/10.1186/s12933-016-0486-2
Ozer PA, Unlu N, Demir MN, Hazirolan DO, Acar MA, Duman S. Serum lipid profile in diabetic macular edema. J Diabetes Complications. 2009;23(4):244-8. DOI: https://doi.org/10.1016/j.jdiacomp.2007.12.004