Aerobic capacity in adults with mild hemophilia compared to healthy adults: a cross-sectional study

Authors

  • Dimple Choudhry College of Physiotherapy, PGIMS Rohtak, Haryana, India
  • Malika Jhandai School of Health Sciences, Om sterling Global University, Hisar, Haryana, India
  • Sudhir Kumar Atri Department of Medicine, PGIMS Rohtak, Haryana, India
  • Renu Chawla College of Physiotherapy, PGIMS Rohtak, Haryana, India
  • Nikita College of Physiotherapy, PGIMS Rohtak, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250243

Keywords:

Activity, Adults, Exercise, Hemophilia, Walk test

Abstract

Background: Hemophilia is an X-linked inherited bleeding disorder that not only affects the joints, and muscle but can also affects other organs. It has been determined that aerobic capacity protects individuals with hemophilia (PWH) from joint impairment. The impact of aerobic capacity on PWH, however, is little understood. Evaluation of aerobic capacity in individuals with hemophilia is a critical aspect of comprehensive care. The integration of these assessments helps tailor the management strategies accordingly.

Methods: 30 participants (males) with the age group of 18-30 years were selected via a convenient sampling method. 30 participants were divided into 2 groups, the hemophilic group (15) and the control group (15). The aerobic capacity was measured with a 6-minute walk test and Queen College step test.

Results: Results from the study showed a mean value of 6-minute walk test and Queen College step test in the control group was 450.8 m 42.5 ml/kg/minute and in the hemophilic group was 324 m 25.7 ml/kg/minute respectively. The data also revealed that the aerobic capacity of the control group and hemophilic groups differed statistically significantly.

Conclusions: Hemophilia affects aerobic capacity in a significant way. These findings highlight the need for attention in physical activity prescription and promotion for patients with hemophilia and need to engage in aerobic or resistive exercise for their health benefits.

Metrics

Metrics Loading ...

References

Cuesta-Barriuso R, Gómez-Conesa A, López-Pina JA. Physiotherapy treatment in patients with hemophilia and chronic ankle arthropathy: a systematic review. Rehab Res Pract. 2013;2013(1):305249. DOI: https://doi.org/10.1155/2013/305249

Rodriguez-Merchan EC. Musculoskeletal complications of hemophilia. HSS J. 2010;6(1):37-42. DOI: https://doi.org/10.1007/s11420-009-9140-9

Montgomery RR, Scott JP. Hemostasis: diseases of the fluid phase. Hematol Infancy Childhood. 1993;1993:1605-50.

Lobet S, Meité ND, Koninckx MI, Van Overstraeten A, Kamagate AM, Hermans C, et al. Implementation and assessment of a self‐and community‐based rehabilitation programme in patients with haemophilia from Côte d’Ivoire. Hemophilia. 2019;25(5):859-66. DOI: https://doi.org/10.1111/hae.13833

Jhandai M, Choudhry D, Atri SK, Bhardwaj P, Yadav K. Walking ability in adults with severe hemophilia: a cross-sectional study. Clin Hematol Int. 2024;6(1). DOI: https://doi.org/10.46989/001c.94374

Baumann K, Hernandez G, Witkop M, Peltier S, Dunn S, Cutter S, et al. Impact of mild to severe hemophilia on engagement in recreational activities by US men, women, and children with hemophilia B: The Bridging Hemophilia B Experiences, Results and Opportunities into Solutions (B‐HERO‐S) study. Eur J Hematol. 2017;98:25-34. DOI: https://doi.org/10.1111/ejh.12852

Negrier C, Seuser A, Forsyth A, Lobet S, Llinas A, Rosas M, et al. The benefits of exercise for patients with haemophilia and recommendations for safe and effective physical activity. Hemophilia. 2013;19(4):487-98. DOI: https://doi.org/10.1111/hae.12118

Heijnen L, Mauser-Bunschoten EP, Roosendaal G. Participation in sports by Dutch persons with hemophilia. Hemophilia. 2000;6:537-46. DOI: https://doi.org/10.1046/j.1365-2516.2000.00422.x

Goto M, Haga N, Takedani H. Physical activity and its related factors in Japanese people with hemophilia. Hemophilia. 2019;1:267-73. DOI: https://doi.org/10.1111/hae.13773

Aykar S, Can F, Sahin F. Relationship between fear of movement and physical activity levels in adult hemophilic individuals. Ann Med Res. 2020;27(1):0219-23. DOI: https://doi.org/10.5455/annalsmedres.2019.10.603

Burr JF, Bredin SS, Faktor MD, Warburton DE. The 6-minute walk test as a predictor of objectively measured aerobic fitness in healthy working-aged adults. Phys Sportsmed. 2011;39(2):133-9. DOI: https://doi.org/10.3810/psm.2011.05.1904

Zhuang J, Huang L, Wu Y, Zhang Y. The effectiveness of a combined exercise intervention on physical fitness factors related to falls in community-dwelling older adults. Clin Interv Aging. 2014;9:131-40. DOI: https://doi.org/10.2147/CIA.S56682

Nabi T, Rafiq N, Qayoom O. Assessment of cardiovascular fitness (VO2 max) among medical students by Queens College step test. Int J Biomed Adv Res. 2015;6(5):418-21.

Tlacuilo‐Parra A, Villela‐Rodriguez J, Garibaldi‐Covarrubias R, Soto‐Padilla J, Orozco‐Alcala J. Functional independence score in hemophilia: a cross‐sectional study assessment of Mexican children. Pediatr Blood Cancer. 2010;54(3):394-7. DOI: https://doi.org/10.1002/pbc.22291

Gooding R, Thachil J, Alamelu J, Motwani J, Chowdary P. Asymptomatic joint bleeding and joint health in hemophilia: a review of variables, methods, and biomarkers. J Blood Med. 2021:209-20. DOI: https://doi.org/10.2147/JBM.S304597

Engelbert RH, Plantinga M, Van der Net J, Van Genderen FR, Van den Berg MH, Helders PJ, et al. Aerobic capacity in children with hemophilia. J Pediatr. 2008;152(6):833-8. DOI: https://doi.org/10.1016/j.jpeds.2007.12.016

von Mackensen S, Gringeri A. Quality of life in hemophilia. In: Textbook of hemophilia. 3rd edn. Wiley-Blackwell; 2014;478-488. DOI: https://doi.org/10.1002/9781118398258.ch64

Choudhry D, Malika, Atri SK, Kumar P, Dhankher P. Association between physical activity and fear of movement in patients with hemophilic arthropathy. Indian J Hematol Blood Transfus. 2024:1-4. DOI: https://doi.org/10.1007/s12288-024-01856-1

Nichols S, Mahoney EM, Sirois PA, Bordeaux JD, Stehbens JA, Loveland KA, et al. HIV-associated changes in adaptive, emotional, and behavioral functioning in children and adolescents with hemophilia: results from the Hemophilia Growth and Development Study. J Pediatr Psychol. 2000;25(8):545-56. DOI: https://doi.org/10.1093/jpepsy/25.8.545

Downloads

Published

2025-01-30

How to Cite

Choudhry, D., Jhandai, M., Kumar Atri, S., Chawla, R., & Nikita. (2025). Aerobic capacity in adults with mild hemophilia compared to healthy adults: a cross-sectional study. International Journal of Research in Medical Sciences, 13(2), 722–725. https://doi.org/10.18203/2320-6012.ijrms20250243

Issue

Section

Original Research Articles