The levels of testosterone, zinc, manganese and selenium in type 2 diabetic patient in South-Eastern Nigeria

Christian Ejike Onah, Samuel C. Meludu, Chudi E. Dioka, Nwakasi K. Nnamah, John Kennedy Nnoli, Ubuo K. Amah, Chidiadi M. Atuegbu, Chika P. Asuoha


Background: This study is aimed at evaluating the levels of some trace elements and testosterone, and to ascertain their possible association in type 2 diabetes mellitus.  

Methods: Ninety male type 2 diabetic subjects and forty five apparently healthy non-diabetic male individuals were recruited into this study. The control group was matched for age with the study subjects and they were all within the age range of 30-67 years. Fasting Plasma Glucose (FPG), testosterone, trace elements (zinc, selenium, manganese), Body Mass Index (BMI) were determined.

Results: This study showed significant decreases in the levels of trace elements (Zn, Se, and Mn) with a concomitant decrease in the levels of testosterone in type 2 diabetic patients (P <0.001). This findings were further strengthened by the strong positive correlation between testosterone and these trace elements (P <0.05).

Conclusion: This suggests that low testosterone level might be as a result of low trace elements considering their role in testosterone production. Therefore, trace elements supplementation is recommended.


Testosterone, Trace elements, Type 2 diabetes, Hyperglycaemia

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