The levels of testosterone, zinc, manganese and selenium in type 2 diabetic patient in South-Eastern Nigeria

Christian Ejike Onah, Samuel C. Meludu, Chudi E. Dioka, Nwakasi K. Nnamah, John Kennedy Nnoli, Ubuo K. Amah, Chidiadi M. Atuegbu, Chika P. Asuoha

Abstract


Background: This study is aimed at evaluating the levels of some trace elements and testosterone, and to ascertain their possible association in type 2 diabetes mellitus.  

Methods: Ninety male type 2 diabetic subjects and forty five apparently healthy non-diabetic male individuals were recruited into this study. The control group was matched for age with the study subjects and they were all within the age range of 30-67 years. Fasting Plasma Glucose (FPG), testosterone, trace elements (zinc, selenium, manganese), Body Mass Index (BMI) were determined.

Results: This study showed significant decreases in the levels of trace elements (Zn, Se, and Mn) with a concomitant decrease in the levels of testosterone in type 2 diabetic patients (P <0.001). This findings were further strengthened by the strong positive correlation between testosterone and these trace elements (P <0.05).

Conclusion: This suggests that low testosterone level might be as a result of low trace elements considering their role in testosterone production. Therefore, trace elements supplementation is recommended.


Keywords


Testosterone, Trace elements, Type 2 diabetes, Hyperglycaemia

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References


Vinay K, Abul KA, Nelson F. Type 2 diabetes mellitus. In: Vinay K, Abul KA, Nelson F, eds. Robbins Pathologic Basis of Disease. 6th ed. Philadelphia: Elsevier Inc.; 1999: 913-926.

Burtis CA, Ashwood ER, Bruns DE. Diabetes. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 4th ed. India: Reed Elsevier; 2008: 854-900.

Rosen ED. Low testosterone in type 2 diabetes: a hidden epidemic, 2004. Available at: www.diabetesincontrol.com/index.php?option=com content&view article&id=2324 20/3/2012.

Arthur CG, John EH. Testosterone. In: Arthur CG, John EH, eds. Textbook of Medical Physiology. 11ed. Philadelphia: Elsevier Saunders; 2006: 1003.

JoAnne B. Farrell, Anjali Deshmukh, Ali A. Baghaie. Low Testosterone and the Association with type 2 Diabetes. Diabet Educator. 2008;34(5):799-806.

Barrett-Connor E, Khaw Khaw K-T, Yen SC. Endogenous sex hormone levels in older adult men with diabetes mellitus. Am J Epidemiol. 2010;132(5):895-901.

Tuvemo T, Gebre-Medhin M. The role of trace elements in juvenile diabetes mellitus. Pediatrics. 2004;12(4):213-9.

Debjit B, Chiranjib KP, Sampath K. A potential medicinal importance of zinc in human health and chronic disease. Int J Pharm Biomed Sci. 2010;1(1):05-11.

Vincent JB. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. 2000;58:67-72.

Kazi TG, Afridi HI, Kazi N, Jamali MK, Arain MB, Jalbani N. Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients. Biol Trace Elem Res. 2008;122:1-18.

Masood N, Baloch GH, Ghori RA, Memon IA, Memon MA, Memon MS. Serum zinc and magnesium in type-2 diabetic patients. J Coll Physicians Surg Pak. 2009;19:483-6.

Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type II diabetes. Diabetes. 1997;46:1786-91.

Akinloye O, Ogunleye K, Oguntibeju OO. Cadmium, lead, arsenic and selenium levels in patients with type 2 diabetes mellitus. Afr J Biotechnol. 2010;9(32):5189-95.

El-Yazigi A, Hannan N, Raines D. Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients. Diabet Res. 1993;22:67-75.

Krsnjavi H, Grgurevic-batinica A, Beker D, Romic Z, Krsnjavi A. Selenium and fertility in men. Trace Elem Med. 1992;9:107-8.

Lee B, Pine M, Johnson L, Rettori V, Hiney JK, Dees WL. Manganese acts centrally to activate reproductive hormone secretion and pubertal development in male rats. Reprod Toxicol. 2006;22:580-5.