Appetite stimulant before meal aids faster recovery from illness: a comprehensive review

Authors

  • Mangesh Tiwaskar Shilpa Medical Research Centre, Rainbow Apts., Avdhoot Nagar, Dahisar (E), Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250026

Keywords:

Anorexia, Appetite stimulants, Lysine, Loss of appetite, Multivitamins, Nutritional deficiencies

Abstract

Loss of appetite (LOA), or anorexia, is a significant health concern that can arise due to various factors such as age, illness, or medication, leading to nutritional deficiencies and impacting overall health and quality of life. LOA can be categorized as acute or chronic, with the latter often associated with serious underlying conditions, including cancer and chronic diseases. This review explores the multifactorial causes, prevalence, and health consequences of LOA, emphasizing the importance of early diagnosis and intervention. A multi-centre survey conducted in India revealed a striking prevalence of LOA, affecting 93.1% of 15,914 participants, particularly those with infectious diseases. Effective management strategies are critical, with tools like the Council on Nutrition Appetite Questionnaire (CNAQ) aiding in the assessment of appetite. Pharmacological interventions, including appetite stimulants, play a role in enhancing food intake, while the combination of multivitamins, zinc, and lysine has been found to support appetite stimulation and improve nutritional status. Understanding the complex interplay of physiological, psychological, and pharmacological factors is vital in developing standardized guidelines for managing LOA. Increasing awareness regarding early diagnosis and timely management is essential to improve nutritional status and quality of life for affected patients.

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References

Marriott BM. Effects of Heat on Appetite. InNutritional Needs in Hot Environments: Applications for Military Personnel in Field Operations. National Academies Press. 1993.

Nagaraj S. Loss of Appetite in Adult Patients: Effectiveness and Safety of an Appetite Stimulating Medication in an Open‐Label, Investigator‐Initiated Study in India. J nutrition and metabolism. 2022;2(1):2661912. DOI: https://doi.org/10.1155/2022/2661912

Tiwaskar M. Perception, Approach and Management of Loss of Appetite: A Cross-sectional, Questionnaire based Physician Survey. J Assoc Physicians India. 2020;68(2):55-60.

Plata-Salamán CR. Anorexia during acute and chronic disease. Nutrition. 1996;1;12(2):69-78. DOI: https://doi.org/10.1016/S0899-9007(96)90702-9

Major GC, Doucet E, Jacqmain M, St-Onge M, Bouchard C, Tremblay A. Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study. British J of Nutrition. 2008;99(5):1157-67. DOI: https://doi.org/10.1017/S0007114507853335

Zou JM, Zhu QS, Liang H, Lu HL, Liang XF, He S. Lysine Deprivation Regulates Npy Expression via GCN2 Signaling Pathway in Mandarin Fish (Siniperca chuatsi). Int J Mol Sci. 2022;23(12):6727. DOI: https://doi.org/10.3390/ijms23126727

Ann AS. inventor; Therapeutic Solution, LLC, assignee. United States patent US10610556. 2020 Apr 7. Available at: https://patents.justia.com. Accesed on 12 August 2024.

Banerjee S., Patel A. Prevalence of loss of appetite in patients visiting primary care physicians: a Crosssectional Survey. Indian J of Medical Sciences. 2017;69(2):2–7.

Langhans W. Anorexia of infection: current prospects. Nutrition. 2000;16(10):996-1005.

Simankowicz P, Stępniewska J, Różański J, Ciechanowski K. Cancer or vitamin B12 deficiency? Difficult differential diagnosis in elderly. Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2020;1;48(288):446-8.

Scrimshaw NS, Suskind RM. Interactions of nutrition and infection. Dental Clinics of North America. 1976;1;20(3):461-72. DOI: https://doi.org/10.1016/S0011-8532(22)01017-5

Ohta R, Ryu Y, Hattori S. Association between transient appetite loss and vitamin B1 deficiency in elderly patients with suspected deficiency. Journal of General and Family Medicine. 2021;22(3):128-33. DOI: https://doi.org/10.1002/jgf2.404

Gura K, Ciccone R. Drugs and Appetite: An Overview of Appetite Stimulants in the Pediatric Patient. ICAN: Infant, Child, & Adolescent Nutrition. 2010;2(6):358-69.

Yalçın N, Armut M, Çakır BK, Demirkan K. Drug-induced nutritional disorders. Clinical Science of Nutrition. 2019;1(3):113-22. DOI: https://doi.org/10.5152/ClinSciNutr.2020.962

Dhillo WS. Appetite regulation: an overview. Thyroid. 2007;1;17(5):433-45. DOI: https://doi.org/10.1089/thy.2007.0018

Pourhassan M, Sieske L, Janssen G, Babel N, Westhoff TH, Wirth R. The impact of acute changes of inflammation on appetite and food intake among older hospitalised patients. Br J Nutr. 2020;28(10):1069-75. DOI: https://doi.org/10.1017/S0007114520002160

Ghannouchi I, Speyer R, Doma K, Cordier R, Verin E. Swallowing function and chronic respiratory diseases: Systematic review. Respir Med. 2016;117:54-64. DOI: https://doi.org/10.1016/j.rmed.2016.05.024

Chang SW, Pan WS, Lozano Beltran D, Oleyda Baldelomar L, Solano MA, Tuero I, et al. Gut hormones, appetite suppression and cachexia in patients with pulmonary TB. PLoS One. 2013;8(1):54564. DOI: https://doi.org/10.1371/journal.pone.0054564

Young-Hyman DL, Davis CL. Disordered eating behavior in individuals with diabetes: importance of context, evaluation, and classification. Diabetes Care. 2010;33(3):683-9. DOI: https://doi.org/10.2337/dc08-1077

Alsayyad AS, Zaid HA, Alsaad AA, Aljewayed BH, Alghanem AA, Alquraini AA, et al. Loss of appetite in hypertensive elderly patients in Alahsa in Saudi Arabia in the summer of 2015. International Journal of Medicine in Developing Countries. 2019;26;3(1):67-73. DOI: https://doi.org/10.24911/IJMDC.51-1541948164

Hellysaz A, Neijd M, Vesikari T, Svensson L, Hagbom M. Viral gastroenteritis: sickness symptoms and behavioral responses. M bio. 2023;25;14(2):3567-22. DOI: https://doi.org/10.1128/mbio.03567-22

Eccles R. Mechanisms of symptoms of common cold and flu. Common Cold. 2009;3:23-45. DOI: https://doi.org/10.1007/978-3-7643-9912-2_2

Rao S, Schieber AM, O’Connor CP, Leblanc M, Michel D, Ayres JS. Pathogen-mediated inhibition of anorexia promotes host survival and transmission. Cell. 2017;26;(3):503-16. DOI: https://doi.org/10.1016/j.cell.2017.01.006

Ramos S, Ademolue TW, Jentho E, Wu Q, Guerra J, Martins R, et al. A hypometabolic defense strategy against malaria. Cell Metabolism. 2022;2(8):1183-200. DOI: https://doi.org/10.1016/j.cmet.2022.06.011

Kitayama M, Unoki T, Sasaki A, Sakuramoto H, Uemura S, Tsujimoto T, et al. Appetite loss and associated factors at 1 year after intensive care unit elder survivors in a secondary analysis of the SMAP-HoPe study. Scientific Reports. 2023;13(1):1079. DOI: https://doi.org/10.1038/s41598-023-28063-8

Ans AH, Anjum I, Satija V, Inayat A, Asghar Z, Akram I, et al. Neurohormonal regulation of appetite and its relationship with stress: A mini literature review. Cureus. 2018;10(7):47. DOI: https://doi.org/10.7759/cureus.3032

Krapić M, Kavazović I, Wensveen FM. Immunological Mechanisms of Sickness Behavior in Viral Infection. Viruses. 2021;13(11):2245. DOI: https://doi.org/10.3390/v13112245

Langhans W. Anorexia of infection: current prospects. Nutrition. 2000;16(10):996-1005. DOI: https://doi.org/10.1016/S0899-9007(00)00421-4

Pecora F, Persico F, Argentiero A, Neglia C, Esposito S. The role of micronutrients in support of the immune response against viral infections. Nutrients. 2020;12(10):3198. DOI: https://doi.org/10.3390/nu12103198

Gura K, Ciccone R. Drugs and AppetiteAn Overview of Appetite Stimulants in the Pediatric Patient. ICAN Infant Child & Adolescent Nutrition. 2010;2(6):358-69. DOI: https://doi.org/10.1177/1941406410387925

Huskisson E, Maggini S, Ruf M. The role of vitamins and minerals in energy metabolism and well-being. J International medical research. 2007;35(3):277-89. DOI: https://doi.org/10.1177/147323000703500301

Singh M, Rao DM, Pande S, Battu S, Mahalakshmi K, Dutt KR, et al. Medicinal uses of L-lysine: past and future. Int. J. Res. Pharm. Sci. 2011;2(4):637-42.

Gunarathne R, Guan X, Feng T, Zhao Y, Lu J. L-lysine dietary supplementation for childhood and adolescent growth: Promises and precautions. J Advanced Research. 2024;11:278-9. DOI: https://doi.org/10.1016/j.jare.2024.05.014

Suzuki H, Asakawa A, Li JB, Tsai M, Amitani H, Ohinata K, et al., Zinc as an appetite stimulator - the possible role of zinc in the progression of diseases such as cachexia and sarcopenia. Recent Pat Food Nutr Agric. 2011;3(3):226-31. DOI: https://doi.org/10.2174/2212798411103030226

Sugeng MW, Adriani M, Wirjatmadi B. The effect of zinc and lysine supplementation on infection rate and cd4 count in elderly. Biochem Physiol. 2015;5(2):367-9. DOI: https://doi.org/10.4172/2168-9652.S5-002

Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, et al., Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J Gastroenterol. 2010;16(19):2378-87.

Li D, Sun WP, Zhou YM, Liu QG, Zhou SS, Luo N, et al. Chronic niacin overload may be involved in the increased prevalence of obesity in US children. World J of Gastroenterology: WJG. 2010;5;16(19):2378. DOI: https://doi.org/10.3748/wjg.v16.i19.2378

Liu L, Wang H, Sun H, Fu C, Liu H, Sun Y, et al. Effects of pyridoxine on selected appetite regulating peptides mRNA expression in hypothalamic PVN/ARC nuclei and gastrointestinal tract tissues. Advances in Bioscience and Biotechnology. 2017;13;8(9):273-82. DOI: https://doi.org/10.4236/abb.2017.89020

Effectiveness and safety of appetite-stimulating syrup in the management of pediatric patients with loss of appetite due to acute or chronic illness: Results of a prospective, single-arm, multi-center, open-label study. Abstract. Presented at: IACMCON. 27th- 29th Sept.2024, India.

Harrison ME, Norris ML, Robinson A, Spettigue W, Morrissey M, Isserlin L. Use of cyproheptadine to stimulate appetite and body weight gain: A systematic review. Appetite. 2019;1;137:62-72. DOI: https://doi.org/10.1016/j.appet.2019.02.012

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Published

2025-01-16

How to Cite

Tiwaskar, M. (2025). Appetite stimulant before meal aids faster recovery from illness: a comprehensive review. International Journal of Research in Medical Sciences, 13(2), 917–926. https://doi.org/10.18203/2320-6012.ijrms20250026

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Review Articles