Drug utilization pattern of antimicrobial agents in postoperative patients of major surgery in the general surgical wards at a tertiary care teaching hospital

Anushri P. Gaikwad; Rohidas M. Barve; Rohini Jagtap

doi:10.18203/2320-6012.ijrms20250250

Authors

Anushri P. Gaikwad Department of Pharmacology, B. J. Government Hospital & Sassoon Group of Hospitals, Pune, Maharashtra, India
Rohidas M. Barve Department of Pharmacology, B. J. Government Hospital & Sassoon Group of Hospitals, Pune, Maharashtra, India
Rohini Jagtap Department of Pharmacology, B. J. Government Hospital & Sassoon Group of Hospitals, Pune, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250250

Keywords:

Anti-microbials agents, Drug utilization pattern, General surgical wards, Major post operative surgeries

Abstract

Background: Antimicrobial agents are prescribed very often inappropriately and have become one of the highly abused drugs. The widespread and indiscriminate use of antimicrobial agents results in emergence of antibiotic resistance. The World Health Organization (WHO) has prioritized the rational use of medications. To evaluate utilization pattern of Antimicrobial Agents in postoperative patients of major surgery.

Methods: This was a non-interventional, observational, cross-sectional study, carried out in General Surgery Department at a tertiary care teaching hospital. Total 385 prescriptions of post-operative cases of major surgeries were analysed, to assess the pattern of antimicrobial agents prescribed, using hospital antimicrobial policy.

Results: In this study number of male patients were 68% and female patients were 32%. Frequency of antimicrobial agents use in 385 patients was 1176 and among them, commonly prescribed antibiotics were metronidazole (92.98%) followed by ceftriaxone (49.35%) amikacin (46.75%) and piperacillin-Tazobactam (36.10%). In 49.35% of patients more than 3 antimicrobial agents were prescribed. Average number of antimicrobial agents per prescription were 3. Effectiveness of antimicrobial agents was confirmed by culture sensitivity report. Culture sensitivity test was done in 326 (84.67%). The percentage of antimicrobial agents used from the hospital antimicrobial policy was 74.82%.

Conclusions: Due to fear of SSI and Hospital acquired infections, use of antibiotics for prolonged postoperative period adds economic burden and development of resistance. Thus, prescribers should be trained for proper implementation of antimicrobial policy and prevention of antimicrobial resistance.

Metrics

Metrics Loading ...

References

Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest. 2002;122(1):262-8. DOI: https://doi.org/10.1378/chest.122.1.262

Bijoy K, Vidyadar RS, Palak P, Chintan SP, Atmaram PP. Drug Prescribing and economic analysis for skin diseases in dermatology OPD of a tertiary care teaching hospital. A periodic audit. Indian Journal of Pharmacy Practice. 2012.

Sreedevi K, Rao JV, Fareedullah MD, Vijayakumar S. A study on the prescription pattern of statins in cardiovascular disease. Der Pharm Lett. 2011;3:393-6.

Revathi R, Sarala N, Baskaran N. Prescribing Pattern of Antimicrobials in Patients during Post- Operative Period – An Observational Study. British Journal of Medicine & Medical Research. 2015;5(10):1213-1219. DOI: https://doi.org/10.9734/BJMMR/2015/11259

Leaper DJ, Edmiston CE. World Health Organization: global guidelines for the prevention of surgical site infection. The Journal of Hospital Infection. 2017;95(2):135-136 DOI: https://doi.org/10.1016/j.jhin.2016.12.016

Ray D, Datta S. A study on antimicrobial agents utilization pattern using anatomical therapeutic chemical / daily defined dose system and adverse drug reaction pattern in the intensive care unit of a tertiary care teaching hospital in the Northeastern state of India. Int J Bas Clin Pharmacol. 2018;7:1612-9. DOI: https://doi.org/10.18203/2319-2003.ijbcp20183032

Khade A, Bashir M, Sheethal A. Prescription Pattern in the Department of Surgery in A Tribal District Hospital of Andhra Pradesh, India. Ann Med Health Sci Res. 2013;3(3):438-41. DOI: https://doi.org/10.4103/2141-9248.117953

Salman MT, Akram MF, Rahman S, Khan FA, Haseen MA, Khan SW. Drug prescribing pattern in surgical wards of a teaching hospital in North India. Ind J the Practise Doc. 2008;5(2):5-8.

Bhansali NB, Gosai TR, Dholaria NK, Suthar SD, Chacko J, Chavda DA, et al. Drug utilization study in post-operative patients in the surgical ward of a tertiary hospital attached with medical college. Der Pharmacia Lettre. 2013;5(1):251-7.

Sharma N, Bhargava M, Chaudhary V, Advani U, Jain A, Bansal A. A prospective study of drug utilization pattern in surgery department in a tertiary care teaching hospital in Rajasthan. UJP 2014;03(02):47- 50.

Mondal S, Pramani S, Mallick B, Sengupta M, Niyogi S, Chaudhuri P. A Drug Utilization Study in the Indoor Ward of the Surgery Department of a Tertiary Care Hospital of Eastern India. IOSR J Den and Med Science. 2015:14(10):42-7.

Hotwani JH, Madkholkar NH. Study of prescription pattern of antimicrobials used in postoperative surgical patients in tertiary care hospital. Int J Basic Clin Pharmacol. 2021;10:627-3. DOI: https://doi.org/10.18203/2319-2003.ijbcp20212068

Brethis CS, Thamizharasan S, Sridevi SA, Kalaiselvi B, Singh MB, Vijaykumar K. A prospective study of the pattern of use of antimicrobial agents in surgical prophylaxis in a tertiary care centre. Int J Pharm Pharm Sci. 2017;9(1):283-7. DOI: https://doi.org/10.22159/ijpps.2017v9i1.15803