Unusual giant cell tumor of the clivus: a case documentation and analysis

Jankrut J. Raiyani; Avni M. Patel; Dharita S. Shah; Tanushka Sharma; Nidhi Patel

doi:10.18203/2320-6012.ijrms20251001

Authors

Jankrut J. Raiyani Department of Radiodiagnosis, SVP Hospital, Smt. NHL Municipal Medical College, Ahmedabad, Gujrat, India
Avni M. Patel Department of Radiodiagnosis, SVP Hospital, Smt. NHL Municipal Medical College, Ahmedabad, Gujrat, India
Dharita S. Shah Department of Radiodiagnosis, SVP Hospital, Smt. NHL Municipal Medical College, Ahmedabad, Gujrat, India
Tanushka Sharma Department of Radiodiagnosis, SVP Hospital, Smt. NHL Municipal Medical College, Ahmedabad, Gujrat, India
Nidhi Patel Department of Radiodiagnosis, SVP Hospital, Smt. NHL Municipal Medical College, Ahmedabad, Gujrat, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20251001

Keywords:

Cranium, Giant cell tumor, Clival mass, Skull base mass

Abstract

Giant cell tumors (GCTs) primarily occur in the epiphyses of long bones and are generally considered histologically benign. However, they can be locally aggressive, with a high rate of local recurrence, and have the potential for distant metastasis. Primary GCT of the clivus is extremely rare and is often misdiagnosed as pituitary macroadenoma or clival chordoma, making treatment controversial. The present report describes the case of a 17-year-old male with GCT located in the skull base originating from the clivus, with the involvement of adjacent cranial nerves, which was successfully treated with trans-nasal trans-sphenoidal surgery. This report contributes to the limited literature regarding GCTs of the skull.

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References

Pai SB, Lalitha RM, Prasad K. Giant cell tumor of the temporal bone - a case report. BMC Ear Nose Throat Disord. 2005;5:8–15. DOI: https://doi.org/10.1186/1472-6815-5-8

Leonard J, Gökden M, Kyriakos M. Malignant giant-cell tumor of the parietal bone: case report and review of the literature. Neurosurg. 2001;48:424–9. DOI: https://doi.org/10.1227/00006123-200102000-00039

Roy S, Joshi NP, Sigamani E. Clival giant cell tumor presenting with isolated trigeminal nerve involvement. Eur Arch Otorhinolaryngol. 2013;270:1167–71. DOI: https://doi.org/10.1007/s00405-012-2249-3

Shibao S, Toda M, Yoshida K. Giant cell tumors of the clivus: Case report and literature review. Surg Neurol Int. 2015;6(25):623-7. DOI: https://doi.org/10.4103/2152-7806.170459

Chakarun C, Forrester D, Gottsegen C, Patel D, White E, Matcuk G. Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics. 2013;33(1):197-211. DOI: https://doi.org/10.1148/rg.331125089

Murphey M, Nomikos G, Flemming D, Gannon F, Temple H, Kransdorf M. Imaging of giant cell tumor and giant cell reparative granuloma of bone: radiologic-pathologic correlation. Radiographics. 2001;21(5):1283-309. DOI: https://doi.org/10.1148/radiographics.21.5.g01se251283

Wolfe JT III, Scheithauer BW, Dahlin DC. Giant cell tumor of the sphenoid bone: Review of 10 cases. J Neurosurg. 1983;59:322–7. DOI: https://doi.org/10.3171/jns.1983.59.2.0322

Laurence DW, David U, Daniel JA, Peter W, Nicholas P. Giant cell tumor of the sphenoid bone. Neurosurg. 1992;30(4):576–81. DOI: https://doi.org/10.1227/00006123-199204000-00017

Mahale A, Pai M, Poornima V, Sahu KK. MRI sequence and characteristic features in 'giant cell tumor' of clivus. J Clin Diagn Res. 2013;7(6):1197-200.

Sharma RR, Mahapatra AK, Pawar SJ. Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 2002;9:41–50. DOI: https://doi.org/10.1054/jocn.2001.0963

Huang PH, Lee CC, Chang PY. Giant cell tumor of the sphenoid bone occurring during pregnancy: successful tumor extirpation via endoscopic transnasal transsphenoidal surgery. Clin Neurol Neurosurg. 2013;115:222–6. DOI: https://doi.org/10.1016/j.clineuro.2012.04.028

Campanacci M, Baldini N, Boriani S. Giant-cell tumor of bone. J Bone Joint Surg Am. 1987;69:106–14. DOI: https://doi.org/10.2106/00004623-198769010-00018

Gupta R, Mohindra S, Mahore A. Giant cell tumor of the clivus. Br J Neurosurg. 2008;22:447–9. DOI: https://doi.org/10.1080/02688690701818943

Zhao J, Qian T, Zhi Z, Li Q, Kang L, Wang J, et al. Giant cell tumor of the clivus: A case report and review of the literature. Oncol Lett. 2014 Dec;8(6):2782-6. DOI: https://doi.org/10.3892/ol.2014.2528

Wang Y, Honda K, Suzuki S. Giant cell tumor at the lateral skull base. Am J Otolaryngol. 2006;27:64–7. DOI: https://doi.org/10.1016/j.amjoto.2005.05.021

Weber AL, Hug EB, Muenter MW, Curtin HD. Giant-cell tumors of the sphenoid bone in four children: radiological, clinical, and pathological findings. Skull Base Surg. 1997;7:163–73. DOI: https://doi.org/10.1055/s-2008-1058592

Company MM, Ramos R. Giant cell tumor of the sphenoid. Arch Neurol. 2009;66:134–5. DOI: https://doi.org/10.1001/archneurol.2008.509

Ruka W, Rutkowski P, Morysinski T. The megavoltage radiation therapy in treatment of patients with advanced or difficult giant cell tumors of bone. Int J Radiat Oncol Biol Phys. 2010;78:494–8. DOI: https://doi.org/10.1016/j.ijrobp.2009.07.1704