Role of adipose tissue in people with obesity and its relationship with the appearance of metabolic diseases

Steven M. Suárez Velastegui; Carmen P. Montes Castro; Myrna A. Córdova Perugachi; Martín I. Rodríguez; Gisella G. Riofrio; Cristhian A. Coral; Carlos A. Chango; Lizeth A. Navas Balarezo

doi:10.18203/2320-6012.ijrms20250281

Authors

Steven M. Suárez Velastegui School of Medicine, UDLA University, Quito, Ecuador
Carmen P. Montes Castro Department of Medicine, Armed Forces Hospital, Pastaza, Ecuador
Myrna A. Córdova Perugachi Ministry of Public Health, Quito, Ecuador
Martín I. Rodríguez Ministry of Public Health, Quito, Ecuador
Gisella G. Riofrio Department of Medicine, Armed Forces Specialty Hospital, Quito, Ecuador
Cristhian A. Coral IPS ARTMEDICA, Medellín, Colombia
Carlos A. Chango School of Medicine, UDLA University, Quito, Ecuador
Lizeth A. Navas Balarezo Intensive Care Unit Department, Ecuadorian Institute of Social Security, Ambat, Ecuador

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250281

Keywords:

Adipose tissue dysfunction, Endoplasmic reticulum stress, Obesity, Unfolded protein response

Abstract

The alteration of adipose tissue plays a fundamental role in the appearance of chronic inflammation diseases; insulin resistance, lipid deposition in obese patients. In recent years it has been shown that under the stimulation of adipocytes in stressful situations, their endoplasmic reticulum generates a response that over activates the inflammatory response of adipose tissue and interferes with normal mentalism, generating the secretion of adipokines, affecting the thermogenic pathways of the tissue. adipose, which causes the manifestation of metabolic syndrome. This article summarizes the relationship between adipocyte endoplasmic reticulum and adipose tissue dysfunction in obese patients.

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