Probiotics to prevent acute respiratory infections in pediatric and adult populations

Alisson Camila Valladares Espinosa; Camila Brito Balanzategui; Albert Isaac Grijalva Velasco; Pierina Inés Cantos Márquez; Marilyn Paola León Cadena; Dario David Chicaiza Jácome; Carlos A. Chango Rodríguez; Galo D. Moreno Pineda

doi:10.18203/2320-6012.ijrms20250290

Authors

Alisson Camila Valladares Espinosa School of Medicine, UDLA University, Quito- Ecuador
Camila Brito Balanzategui School of Medicine, UDLA University, Quito- Ecuador
Albert Isaac Grijalva Velasco School of Medicine, Guayaquil University, Guayaquil- Ecuador
Pierina Inés Cantos Márquez School of Medicine, Guayaquil University, Guayaquil- Ecuador
Marilyn Paola León Cadena School of Medicine, Escuela Superior Politécnica de Chimborazo University, Riobamba- Ecuador
Dario David Chicaiza Jácome School of Medicine, Central University, Quito, Ecuador
Carlos A. Chango Rodríguez School of Medicine, UDLA University, Quito- Ecuador
Galo D. Moreno Pineda School of Medicine, UDLA University, Quito- Ecuador

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250290

Keywords:

Probiotics, Respiratory tract diseases, Microbiota

Abstract

Respiratory tract diseases are among the most common infections of childhood and adolescence. Probiotics in recent years have been presented as a promise and prophylactic and curative alternative for various digestive, mental and respiratory pathologies. This is attributed to the great influence that the intestinal microbiota exerts on the immune system. Multiple studies indicate that an impact on the microbiota due to external or internal factors generates an alteration of the immune system. Among the uses that currently exist, they are used for the prevention and treatment of respiratory diseases in children, adolescents and adults. From the studies analysed, it is observed that Lactobacillus casei shows better results in the prevention of upper respiratory diseases than the rest of the probiotics in combination or alone, however the necessary administration time is unknown.

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References

Toivonen L. Burden of recurrent respiratory tract infections in children: a prospective cohort study. Pediatr Infect Dis J. 2016;35(12):362–9. DOI: https://doi.org/10.1097/INF.0000000000001304

Vouloumanou EK. Probiotics for the prevention of respiratory tract infections: a systematic review. Int J Antimicrob Agents. 2019;343:191–10.

Hao Q. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev. 2011;9:6895. DOI: https://doi.org/10.1002/14651858.CD006895.pub2

Agustina R. Randomized trial of probiotics and calcium on diarrhea and respiratory tract infections in indonesian children. Pediatrics. 2020;129:1155–64. DOI: https://doi.org/10.1542/peds.2011-1379

K. M. Global burden of acute respiratory infections in children: implications for interventions. Pediatr Pulmonol. 2017;36:469–74. DOI: https://doi.org/10.1002/ppul.10344

Kalliomaki M I. Role of intestinal flora in the development of allergy. urr Opin Allergy Clin Immunol. 2013;3:15–20. DOI: https://doi.org/10.1097/00130832-200302000-00003

Chiu LB. Protective microbiota: from localized to long-reaching community. Front Immunol. 2017;8:1678. DOI: https://doi.org/10.3389/fimmu.2017.01678

Budden KF G. Emerging pathogenic links between microbiota and the gut-lungaxis. Nat Rev Microbiol. 2017;15(1):55–63. DOI: https://doi.org/10.1038/nrmicro.2016.142

Kumpu M. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2022;66:1020–3. DOI: https://doi.org/10.1038/ejcn.2012.62

Rautava SS. Specific probiotics in reducing the risk of acute infections in infancy? A randomised, doubleblind, placebo-controlled study. Br J Nutr. 2019;101:1722–6. DOI: https://doi.org/10.1017/S0007114508116282

Hatakka K. Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. Clin Nutr. 2017;26:314–21. DOI: https://doi.org/10.1016/j.clnu.2007.01.003

Merenstein D. Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial. Eur J Clin Nutr. 2020;64:669–77. DOI: https://doi.org/10.1038/ejcn.2010.65

Hori TK. Eduction of influenza virus titerin aged mice fed lacto-bacilluscasei strain shirota. Clin Diagn Lab Immuno. 2022;1:105. DOI: https://doi.org/10.1128/CDLI.9.1.105-108.2002

KhailovaL B. Lactobacillus rhamnosus GG improves out come in experimental pseudomonas aeruginosa pneumonia. Shock. 2022;40(6):496–503. DOI: https://doi.org/10.1097/SHK.0000000000000066

Panigrahi P. A randomized synbiotic trial to prevent sepsis among infants in rural India Nature. Nature. 2017;547(12):407. DOI: https://doi.org/10.1038/nature23480

Zhao Y D. Probiotics for preventing acute upper respiratory tract infections. Cochrane Database Syst Rev. 2022;8(8):6895. DOI: https://doi.org/10.1002/14651858.CD006895.pub4

Wypych T. The influence of the microbiome on respiratory health. Nat Immunol. 2019;20(1279):90. DOI: https://doi.org/10.1038/s41590-019-0451-9

Liu S. Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta-analysis of randomized, placebo-controlled trials. Indian Pediatr. 2023;50:377–81. DOI: https://doi.org/10.1007/s13312-013-0123-z