Histopathological Spectrum of various gastroduodenal lesions in North India and prevalence of Helicobacter pylori infection in these lesions: a prospective study

Authors

  • Poonam Sharma Department of Pathology, GMC Hospital, Jammu University, Jammu, J&K
  • Kuldeep Kumar Kaul Department of Pathology, GMC Hospital, Jammu University, Jammu, J&K
  • Manik Mahajan Department of Radio-diagnosis and Imaging, PGIMS, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana
  • Puneet Gupta Department of Radio-diagnosis and Imaging, ASCOMS Hospital, Jammu University, Jammu, J&K

Keywords:

Helicobacter pylori, Gastritis, Duodenal ulcer, Gastric carcinoma

Abstract

Background: Gastroduodenal diseases are perhaps the commonest diseases in adult population worldwide. Helicobacter pylori (H. pylori) represent one of the most common gastroduodenal infections and have been established as the etiologic factor in the development of various gastroduodenal diseases. Spectrum of H. pylori associated gastroduodenal diseases have not been systematically investigated in North India. So this study was carried out to determine the spectrum of gastroduodenal lesions on upper Gastro-Intestinal (GI) endoscopic biopsies and to determine the prevalence of H. pylori in gastric mucosa in these lesions.

Methods: Gastroduodenal mucosal biopsies of 100 patients from November 2012 to October 2013 in a tertiary care centre in north India were evaluated by routine histopathological methods and the presence of H. pylori in gastric mucosa in these lesions was determined.  

Results: An age range of 17 years to 80 years was observed with maximum cases in the 4th decade and a male to female ratio of 1.86:1. The most frequently observed lesions were chronic gastritis followed by duodenitis, duodenal ulcer and gastric carcinoma. 5% cases showed unremarkable mucosa. H. pylori positivity was seen in 47% cases. 80% cases of duodenal ulcer, 68.75% cases of duodenitis, 50.56% cases of chronic gastritis, 50% cases of gastric ulcer & 40% cases of gastric carcinoma were positive for H. pylori infection.

Conclusion: Endoscopic gastroduodenal biopsies help to detect benign and malignant gastroduodenal diseases and to rule out H. pylori infection. Chronic gastritis was the most common gastroduodenal lesion followed by duodenitis, duodenal ulcer and gastric carcinoma. Duodenal ulcer, duodenitis, chronic gastritis and gastric ulcer showed strong positivity for H. pylori highlighting the role of this microorganism in the pathogenesis of these diseases.

 

References

Ahsan K, Hossain MZ, Uddin MR. Role of crush cytology for the detection of Helicobacter pylori in gastroduodenal diseases. J Dhaka Med Coll. 2008;17(2):88-92.

Gulia SP, Chaudhury M, Noorunnisa N, Balakrishnan CD, Balagurunathan K. Interpretation of upper GI tract endoscopic mucosal biopsies - a study conducted in teaching hospital in Puducherry, India. Int J Med Health Sci. 2012 July;1(3):17-24.

Mustapha SK, Ajayi NA, Nggada HA, Pindiga UH, Bolori MT, Ndahi A, et al. Endoscopic findings and the frequency of Helicobacter pylori among dyspeptic patients In North-Eastern Nigeria. Highland Med Res J. 2007;5(1):78-81.

Bhatty SA, Shaikh NA, Zahir N, Akhter SS, Vaswani AS, Manzoor H. Histopathologic spectrum of upper GI endoscopies. Med Channel. 2009;15(4):11-4.

Jones DM, Lessels AM, Elridge J. Campylobacter like organisms on the gastric mucosa: culture, histological and serological studies. J Clin Pathol. 1984 Sep;37(9):1002-6.

Versalovic J. Helicobacter pylori. Pathology and diagnostic strategies. Am J Clin Pathol. 2003 Mar;119(3):403-12.

Blackstone MO. Endoscopic interpretation. In: Blackstone MO, eds. Normal and Pathologic Appearances of the GI Tract. 1st ed. New York: Raven Press; 1984: 13-15.

Afzal S, Ahmad M, Mubarik A, Saeed F, Rafi S, Saleem N, Qur AH. Morphological spectrum of gastric lesions-Endoscopic biopsy findings. Pak Armed Forces Med J. 2006 Jun;56(2):143-9.

Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984 Jun;1(8390):1311-5.

Goodwin CS, Armstrong JA, Chilvers T, Peters M, Colins MD, Sly L, et al. Transfer of Campylobacter pylori and Campylobacter mustelae to Helicobacter gen nov as Helicobacter pylon comb nov and Helicobacter mustelae comb nov, respectively. Int J Syst Bacteriol. 1989;39:397-405.

Makola D, Peura DA, Crowe SE. Helicobacter pylori Infection and related GI Diseases. J Clin Gastroenterol. 2007 Jul;41(6):548-58.

Ohkusa T, Fujiki K, Takashimizu I, Kumagai J, Tanizawa T, Eishi Y. Endoscopic and histological comparison of nonulcer dyspepsia with and without Helicobacter pylori infection evaluated by the modified Sydney system. Am J Gastroenterol. 2000 Sep;95(9):2195-9.

Al-Hamdani AA, Fayady MH, Majeed BAA. Helicobacter pylori gastritis: correlation between the endoscopic and histological findings. IJGE. 2001;1(1):43-8.

Kate V, Ananthakrishnan N, Badrinath S, Ratnakar C. Prevalence of Helicobacter pylori infection in disorders of the upper GI tract in south India. Natl Med J India. 1998 Jan-Feb;11(1):5-8.

Graham DY. Campylobacter pylori and peptic ulcer disease. Gastroenterology. 1989 Feb;96(2):615-25.

Loffeld RJ, Willems I, Flendrig JA, Arends JW. Helicobacter pylori and gastric carcinoma. Histopathology. 1990 Dec;17(6):537-41.

Issacson PG. Extranodal lymphomas: the MALT concept. Verh Dtsch Ges Pathol. 1992;76:14-23.

18. Cutler AF. Testing for H pylori in clinical practice. Am J Med. 1996 May 20;100(5A):35S-41S.

Kacar F, Culhaci N, Yukselen V, Meteoglu I, Dikicioglu E, Levi E. Histologic demonstration of Helicobacter pylori in gastric biopsies: which is the best staining method? Internet J Pathol. 2004;3(1):3.

Kadam PN, R Chavan YH, Shinde A, Hanmante RD. The histopathological study of gastroduodenal biopsies and Helicobacter pylori infection in acid peptic disease patients. J Evol Med Dent Sci (JEMDS). 2013 July;2(27):4883-9.

Godkhindi VM, Meshram DP, Deshpande SA, Kadam PN, Chavan YH. The histopathological study of various gastro-duodenal lesions and their association with Helicobacter pylori infection. IOSR-JDMS. 2013 Jan-Feb;4(3):51-5.

Kumar R, Bano G, Kapoor B, Sharma S, Gupta Y. Clinical profile in H. pylori positive patients in Jammu. JK Sci. 2006;8(3):148-50.

Adibfar P, Mirsalehian A, Ghofrani H, Alavi M, Ragabi A. The association of Campylobacter pylori (Helicobacter pylori) with gastritis and peptic ulcer. Med J Islam Repub Iran (MJIRI). 1991;5(1,2):19-22.

Qamar S, Bukhari M, Asrar A, Sarwar S, Niazi S. Evaluation of antral gastric biopsies. A study of 50 patients at Mayo hospital. Spec Ed Ann. 2010 Jan-Mar;16(1):45-50.

Akanda MR, Rahman AN. Comparative Study of different methods for detection of Helicobacter pylori in gastric biopsies. Dinajpur Med Coll J. 2011 Jan;4(1):1-6.

Satoskar A, Vora IM. Incidence of Helicobacter pylori associated gastritis in the urban population from India. Trop Geogr Med. 1994;46(3):167-8.

Sharma M, Mehta P, Vohra P. Incidence of Helicobacter pylori in patients with gastroduodenal disorders. Innov J Med Health Sci (IJMHS). 2013 Jan-Feb;3(1):10-5.

Bago J, Kranjčec D, Strinić D, Petrović Z, Kučišec N, Bevanda M, et al. Relationship of gastric metaplasia and age, sex, smoking and Helicobacter pylori Infection in patients with duodenal ulcer and duodenitis. Coll Antropol. 2000 Jun;24(1):157-65.

Mazlam MZ. Helicobacter pylori infection in Malaysia. Med J Malaysia. 1995 Sep;50(3):205-7.

Prabhu SR, Amrapurkar AD, Amrapurkar ON. Role of Helicobacter pylori in gastric carcinoma. Natl Med J India. 1995 Mar-Apr;8(2):58-60.

Downloads

Published

2017-01-08

How to Cite

Sharma, P., Kaul, K. K., Mahajan, M., & Gupta, P. (2017). Histopathological Spectrum of various gastroduodenal lesions in North India and prevalence of Helicobacter pylori infection in these lesions: a prospective study. International Journal of Research in Medical Sciences, 3(5), 1236–1241. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/1474

Issue

Section

Original Research Articles