Novel use of famotidine in treatment of frozen shoulder: a case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20250704Keywords:
Famotidine, Frozen shoulder, Acidosis, GPR4, Inflammation, Shoulder pain and disability indexAbstract
Famotidine is a H2 receptor blocker used to reduce gastric acid secretion. This case report highlights a novel use of famotidine. It may be used in the treatment of frozen shoulder. Frozen shoulder is a pathological condition characterised by restricted shoulder movement. We present a case report of a diabetic and hypertensive patient suffering from frozen shoulder along with hyperacidity and gastroesophageal reflux disease (GERD). Famotidine was prescribed for treatment of GERD. Famotidine not only provides relief from acidity but also results in decrease in pain score, disability score and shoulder pain and disability index (SPADI) due to frozen shoulder with improved movement. This therapeutic importance encourages us to report the significance of Famotidine in frozen shoulder. This also opens a new dimension in the role of acidity in the study of pathophysiology of frozen shoulder.
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Cho CH, Song KS, Kim BS, Kim DH, Lho YM. Biological aspect of pathophysiology for frozen shoulder. BioMed Res Int. 2018;2018:7274517. DOI: https://doi.org/10.1155/2018/7274517
Zampieri FG, Kellum JA, Park M, Ranzani OT, Barbeiro HV, de Souza HP, et al. Relationship between acid–base status and inflammation in the critically ill. Critical Care. 2014;18(4):R154. DOI: https://doi.org/10.1186/cc13993
Lipsy RJ, Fennerty B, Fagan TC. Clinical review of histamine2 receptor antagonists. Archives of internal medicine. 1990;150(4):745-51. DOI: https://doi.org/10.1001/archinte.1990.00390160023006
Casimir GJ, Lefèvre N, Corazza F, Duchateau J, Chamekh M. The Acid–Base Balance and Gender in Inflammation: A Mini-Review. Frontiers in immunology. 2018;9:475. DOI: https://doi.org/10.3389/fimmu.2018.00475
Riemann A, Ihling A, Thomas J, Schneider B, Thews O, Gekle M. Acidic environment activates inflammatory programs in fibroblasts via a cAMP–MAPK pathway. Biochimica et Biophysica Acta (BBA)-Molecular Cell Res. 2015;1853 (2):299-307. DOI: https://doi.org/10.1016/j.bbamcr.2014.11.022
Breckenridge JD, McAuley JH. Shoulder pain and disability index (SPADI). J Physioth. 2011;57(3):197. DOI: https://doi.org/10.1016/S1836-9553(11)70045-5
Tveitå EK, Ekeberg OM, Juel NG, Bautz-Holter E. Responsiveness of the shoulder pain and disability index in patients with adhesive capsulitis. BMC Musculoskeletal Disord. 2008;9:1-8. DOI: https://doi.org/10.1186/1471-2474-9-161
Saoji KK, Gawande V, Dulani R. A comparative study of disability and pain assessment by Shoulder Pain and Disability Index (SPADI) Score in patients of adhesive capsulitis treated by hydro-dilatation with and without corticosteroids. Int J Cur Res Rev. 2020;12(14):35-40. DOI: https://doi.org/10.31782/IJCRR.2020.3540
Conrad M, Söldner CA, Miao Y, Sticht H. Agonist Binding and G Protein Coupling in Histamine H2 Receptor: A Molecular Dynamics Study. Int J Mol Sci. 2020 ;21(18):6693. DOI: https://doi.org/10.3390/ijms21186693
Jing Z, Xu H, Chen X, Zhong Q, Huang J, Zhang Y, et al. The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer. PLoS One. 2016;11(4):e0152789. DOI: https://doi.org/10.1371/journal.pone.0152789
Chen A, Dong L, Leffler NR, Asch AS, Witte ON, Yang LV. Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway. PloS One. 2011;6(11):e27586. DOI: https://doi.org/10.1371/journal.pone.0027586
Wang Y, de Vallière C, Imenez Silva PH, Leonardi I, Gruber S, Gerstgrasser A, et al. The proton-activated receptor GPR4 modulates intestinal inflammation. J Crohn's Colitis. 2018;12(3):355-68. DOI: https://doi.org/10.1093/ecco-jcc/jjx147
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