Relationship between chronic periodontitis and metabolic syndrome: a case-control study

Manovijay Balagangadharan, Deepa Subramaniam, Mythili Swaminathan, Ravi Saranyan, Vel Latha Kathiresan, Raja Arassappan

Abstract


Background: The aim of this case-control study was to investigate the periodontal status of patients with metabolic syndrome compared to general healthy individuals and to determine whether the periodontal status was consistent with the values of the metabolic components.

Methods: A total of ninety patients were examined in this study. Group one consisted of forty five patients who were confirmed to have metabolic syndrome and group two consisted of forty five age and sex matched healthy controls. Plaque index, Gingival Bleeding Index (Ainamo & Bay), Probing Pocket Depth (PPD), Clinical Attachment Level (CEJ), total number of missing teeth and the reasons for extraction were also noted. Medical examination and blood investigations included measurement of height, weight, waist circumference, waist-hip ratio, Body-Mass Index (BMI), serum lipid profile, fasting blood glucose and blood pressure. Metabolic syndrome was defined according to NCEP ATP III definition. The results obtained were analyzed statistically using SYSTAT html output.

Results: The results of the present study showed that the periodontal condition of group one patients were poor compared to group two patients. The periodontal conditioned worsened with an increase in the metabolic components.

Conclusion: Based on the results of our study, it can be concluded that that periodontitis and metabolic syndrome were confounding the systemic effects of each other. Dentists should counsel their patients regarding the health hazards of metabolic syndrome and periodontitis and motivate them to maintain good oral hygiene and follow healthy life-style.

 

Keywords: Chronic periodontitis, Metabolic syndrome (MS), Systemic diseases


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References


American Academy of Periodontology. Parameter on chronic periodontitis with slight to moderate loss of periodontal support. J Periodontol. 2000;71:853-5.

Rateitschak KH, Rateitschak EM, Wolf HF. Gingival bleeding index. In: Rateitschak KH, Rateitschak EM, Wolf HF, eds. Color Atlas of Periodontology. 2nd ed. New York: Thieme; 1985: 27-29.

Armitage GC. The complete periodontal examination. Periodontology 2000. 2004;34:22-33.

Ninomiya JK, L’Italien G, Criqui MH, Whyte JL, Gamst A, Chen RS. Association of the metabolic syndrome with history of myocardial infarction and stroke in the third national health and nutrition examination survey. Circulation. 2004;109:42-6.

J. Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol. 2001;28:865-8.

M. BulloPilarGarcı a-Lorda, Isabel Megias, Jordi Salas Salvado. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res. 2003 Apr;11(4):525-31.

Trayhurn P, Wood IS. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans. 2005 Nov;33(Pt 5):1078-81.

Seth S. Martin, Atif Qasim, Muredach P. Reilly. Leptin resistance: a possible interface of inflammation and metabolism in obesity-, related cardiovascular disease. J Am Coll Cardiol. 2008;52:1201-10.

Guerre-Mito M. Adipose tissue and adipokines: for better or worse. Diabetes Metab. 2004;30:13-9.

Seth S. Martin, Atif Qasim, Muredach P. Reilly. Leptin resistance: a possible interface of inflammation and metabolism in obesity-, related cardiovascular disease. J Am Coll Cardiol. 2008;52:1201-10.

Guerre-Mito M. Adipose tissue and adipokines: for better or worse. Diabetes Metab. 2004;30:13-9.

Erin E. Kershaw, Jeffrey S. Filer. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab. 2004;89:2548-56.

Toshiyuki Saito, Yoshihiro Shimazaki. Metabolic disorders related to obesity and periodontal disease. Periodontology 2000. 2007;43:254-66.

Louis E. Rose, Robert J. Genco, D. Walter Cohen, Brim L. Mealey. Periodontal medicine. In: Louis E. Rose, Robert J. Genco, D. Walter Cohen, Brim L. Mealey, eds. A Book. 7th ed. London: B.C. Decker; 2000.

Martha E. Nunn. Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontology 2000. 2003;32:11-23.

Seymour RA. Does periodontal treatment improve general health? Dent Update. 2010 May;37(4):206-8.

LöscheW,Karapetow F, Pohl C, Kocher T. Plasma Lipid and glucose levels in patients with destructive periodontal disease. J Clin Periodontol. 2000;27:537-5.

Katz J, Chaushu G, Sharabi Y. On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol. 2001;28:865-8.

Joseph Katz, Mosche Y. Flugleman, Avishai Goldberg, Marc Heft. Association between periodontal pockets and low density lipoprotein levels. J Periodontol. 2002;73:494-500.

Manbu Morita, Manazumi Horiuchi, Yuka Kinoshita, Tatsuo Yamamoto, Tatsuo Watanabe. Relationship between blood triglyceride levels and periodontal status. Community Dent Health. 2004;21:32-6.

Amir Moeintaghavi, Mohammadreza Taiebi, Ardakani. Hyperlipidemia in patients with periodontitis. J Contemp Dent Pract. 2005 Aug;(6)3:078-85.

Giedre Valentavinciene, Pajauta Paipaliene, Irena Nedzelskiene, Juozas Zilinskas, Ona Vidute Anuseviciene. The relationship between blood serum lipids and periodontal condition. Stomatol Baltic Dent Maxillofac J. 2006;8(3):96-100.

Nibali L, D’Aiuto F, Griffiths G, Patel K, Suvan J, Tonetti MS. Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case-control study. J Clin Periodontol. 2007;34:931-7.

Abhijit N. Gurav. The association of periodontitis and metabolic syndrome. Dent Res J (Isfahan). 2014 Jan-Feb;11(1):1-10.

Bullon P, Morillo JM, Ramirez-Tortosa MC, Quiles JL, Newman HN, Battino M. Metabolic syndrome and periodontitis: is oxidative stress a common link? J Dent Res. 2009 Jun;88(6):503-18.

Anders Holmlund, Johannes Hult, Lars Lind. Tooth loss is related to the presence of metabolic syndrome and inflammation in elderly subjects: a prospective study of the vasculature in Uppsala seniors. Oral Health Prev Dent. 2007;2:125-33.

Montebugnoli L, Servidio D, Miaton RA, Prati C, Tricoci P, Melloni C, et al. Periodontal health improves systemic inflammatory and haemostatic status in subjects with coronary heart disease. J Clin Periodontol. 2005 Feb;32(2):188-92.