Pulmonary infarction with phlegmasia cerulea dolens: a sequelae of deep vein thrombosis

Authors

  • Rashmi Gupta Bajpai Department of Internal Medicine, SGT Medical College, Gurugram, Haryana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250366

Keywords:

DVT, Pulmonary infarction, PCD, Aspergillus flavus, Sepsis

Abstract

Deep vein thrombosis (DVT) can lead to severe complications such as pulmonary embolism and phlegmasia cerulea dolens (PCD), both of which are life-threatening conditions. The coexistence of infected pulmonary infarction and PCD is exceptionally rare, demanding timely diagnosis and multidisciplinary management. A 70-year-old male with diabetes and sepsis presented with fever, limb pain, and swelling. Investigations included Doppler ultrasound, computed tomography (CT) angiography, and positron emission tomography (PET) - CT scans, confirming DVT, pulmonary embolism, and Aspergillus flavus infection. The patient was managed with anticoagulation, antifungal therapy, and glycemic control. The left popliteal vein thrombus measured 3.5 cm, with thrombosis extending to the right superficial femoral vein. Blood glucose was 250 mg/dl, creatinine 1.5 mg/dl, and leukocyte count 18,000 cells/mm3. After treatment, leukocyte count normalized to 10.23×103 cells/mm3, and limb pain resolved. Follow-up revealed substantial clinical improvement by discharge on 11 January 2023. This case highlights the importance of early recognition and a multidisciplinary approach to managing infected pulmonary infarction and PCD in patients with DVT.

Metrics

Metrics Loading ...

References

Kesieme E, Kesieme C, Jebbin N, Irekpita E, Dongo A. Deep vein thrombosis: a clinical review. J Blood Med. 2011;2:59-69. DOI: https://doi.org/10.2147/JBM.S19009

Line BR. Pathophysiology and diagnosis of deep venous thrombosis. In Seminars in nuclear medicine. WB Saunders. 2001;31(2):90-101. DOI: https://doi.org/10.1053/snuc.2001.21406

Hattab Y, Küng S, Fasanya A, Ma K, Singh AC, DuMont T. Deep Venous Thrombosis of the Upper and Lower Extremity. Crit Care Nurs Q. 2017;40(3):230-6. DOI: https://doi.org/10.1097/CNQ.0000000000000165

Stouffer GA, Sheahan RG, Lenihan DJ, Gupta R. Deep venous thrombosis: a review of the pathophysiology, clinical features, and diagnostic modalities. Am J Med Sci. 2001;322(6):358-64. DOI: https://doi.org/10.1097/00000441-200112000-00009

Heil J, Miesbach W, Vogl T, Bechstein WO, Reinisch A. Deep Vein Thrombosis of the Upper Extremity. Dtsch Arztebl Int. 2017;114(14):244-9. DOI: https://doi.org/10.3238/arztebl.2017.0244

Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet. 2012;379(9828):1835-46. DOI: https://doi.org/10.1016/S0140-6736(11)61904-1

Monreal M, Ruíz J, Olazabal A, Arias A, Roca J. Deep venous thrombosis and the risk of pulmonary embolism. A systematic study. Chest. 1992;102(3):677-81. DOI: https://doi.org/10.1016/S0012-3692(16)39090-0

Nielsen JD. The incidence of pulmonary embolism during deep vein thrombosis. Phlebology. 2013;28 Suppl 1:29-33. DOI: https://doi.org/10.1177/0268355513477009

Thomas DR, Cote TR, Lawhorne L, Levenson SA, Rubenstein LZ, Smith DA, et al; Dehydration Council. Understanding clinical dehydration and its treatment. J Am Med Dir Assoc. 2008;9(5):292-301. DOI: https://doi.org/10.1016/j.jamda.2008.03.006

Hirsh J, Hull RD, Raskob GE. Clinical features and diagnosis of venous thrombosis. J Am Coll Cardiol. 1986;8(6 Suppl B):114B-27B. DOI: https://doi.org/10.1016/S0735-1097(86)80013-4

Baldassarri RJ, Kumar D, Baldassarri S, Cai G. Diagnosis of Infectious Diseases in the Lower Respiratory Tract: A Cytopathologist's Perspective. Arch Pathol Lab Med. 2019;143(6):683-94. DOI: https://doi.org/10.5858/arpa.2017-0573-RA

Krishnan S, Manavathu EK, Chandrasekar PH. Aspergillus flavus: an emerging non-fumigatus Aspergillus species of significance. Mycoses. 2009;52(3):206-22. DOI: https://doi.org/10.1111/j.1439-0507.2008.01642.x

Bilimoria KY, Chung J, Ju MH, Haut ER, Bentrem DJ, Ko CY, et al. Evaluation of surveillance bias and the validity of the venous thromboembolism quality measure. JAMA. 2013;310(14):1482-9. DOI: https://doi.org/10.1001/jama.2013.280048

Turina M, Fry DE, Polk HC Jr. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med. 2005;33(7):1624-33. DOI: https://doi.org/10.1097/01.CCM.0000170106.61978.D8

Wensveen FM, Šestan M, Turk Wensveen T, Polić B. Blood glucose regulation in context of infection. Vitam Horm. 2021;117:253-318. DOI: https://doi.org/10.1016/bs.vh.2021.06.009

Giri B, Dey S, Das T, Sarkar M, Banerjee J, Dash SK. Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity. Biomed Pharmacother. 2018;107:306-28. DOI: https://doi.org/10.1016/j.biopha.2018.07.157

Buttaro TM, Aznavorian S, Dick K. Clinical management of patients in subacute and long-term care settings. Elsevier Health Sciences. 2006.

Downloads

Published

2025-02-17

How to Cite

Bajpai, R. G. (2025). Pulmonary infarction with phlegmasia cerulea dolens: a sequelae of deep vein thrombosis. International Journal of Research in Medical Sciences, 13(3), 1275–1279. https://doi.org/10.18203/2320-6012.ijrms20250366

Issue

Section

Case Reports