Ceftriaxone induced neurotoxicity: a word of caution for elderly and patients with renal impairment

Authors

  • Harshit Gupta Department of Internal Medicine, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India
  • Prateek Jain Department of Internal Medicine, All India Institute of Medical Sciences Rishikesh, Uttarakhand, India
  • Prayag Jariwala Department of Internal Medicine, Government Medical College Surat, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20251348

Keywords:

Ceftriaxone, Neurotoxicity, Letter to the Editor

Abstract

Ceftriaxone is a third-generation cephalosporin commonly used in inpatient settings and is associated with both hepatic and renal excretion. The cephalosporin group, particularly the fourth generation, including cefepime, has been commonly associated with encephalopathy, but recent literature has also suggested an increasing trend of encephalopathy related to ceftriaxone.

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References

Hagiya H, Miyawaki K, Yamamoto N. Ceftriaxone-induced Neurotoxicity in a Patient after Pancreas-Kidney Transplantation. Intern Med. 2017;56(22):3103–7. DOI: https://doi.org/10.2169/internalmedicine.8774-16

Safadi S, Mao M, Dillon JJ. Ceftriaxone-Induced Acute Encephalopathy in a Peritoneal Dialysis Patient. Case Rep Nephrol. 2014;2(1):108185. DOI: https://doi.org/10.1155/2014/108185

Zarauskas A, Rodrigues B, Alvarez V. Ceftriaxone-induced encephalopathy in a patient with a normal renal function. BMJ Case Rep CP. 2024;17(1):256934. DOI: https://doi.org/10.1136/bcr-2023-256934

Takano T, Kaburagi M, Morikubo S. Ceftriaxone-Related Encephalopathy in a Patient With End-Stage Renal Disease and High Ceftriaxone Concentrations in Cerebrospinal Fluid and Plasma: A Case Report. Cureus. 2016;15(10):46401.

Nishioka H, Cho Y, Irie K. Ceftriaxone-associated encephalopathy in a patient with high levels of ceftriaxone in blood and cerebrospinal fluid. Int J Infect Dis. 2022;116:223–5. DOI: https://doi.org/10.1016/j.ijid.2022.01.023

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Published

2025-04-29

How to Cite

Gupta, H., Jain, P., & Jariwala, P. (2025). Ceftriaxone induced neurotoxicity: a word of caution for elderly and patients with renal impairment. International Journal of Research in Medical Sciences, 13(5), 2279–2280. https://doi.org/10.18203/2320-6012.ijrms20251348

Issue

Section

Letter to the Editor