Incidence of Rh alloimmunisation and its effects on pregnancy outcome in a tertiary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20250971Keywords:
Red cell alloimmunisation, Anti D immunoglobulin, Hemolytic disease of newbornAbstract
Background: Red cell alloimmunization results from transplacental passage of maternal antibodies that destroy fetal red cells. The aim of the study is to determine incidence, maternal and perinatal outcome in Rh negative pregnancy.
Methods: A retrospective observational study was conducted in the Department of Obstetrics and Gynaecology, Shri Lal Bahadur Shastri Medical College, Mandi, Himachal Pradesh for period of one year from 01 January 2024 to 31 December 2024. All the pregnant women admitted in labour ward with Rh negative pregnancy were included in the study.
Results: The incidence of Rh negative pregnancy was 6.1% in one-year study period. Most common age group was 26-30 years comprising 42.8% cases. Majority of the patients were multipara (53.57%). Only 1.78% Rh negative pregnant women had positive indirect Coombs test. One patient was delivered at 34 weeks of gestation, 3 (1.33%) at 36 weeks and 220 (98.21%) at term (37-40) weeks of gestation. About 10.71% neonates had neonatal jaundice, 87.05% neonates had uneventful neonatal outcome.
Conclusions: Early detection, timely intervention and motivation of the Rh negative patients can prevent maternal, fetal and neonatal complications.
Metrics
References
Dutta DC. Antepartum haemorrhage. Konar H, editor. Textbook of obstetrics. 10th edition. New Central Book Agency, Calcutta. 2023;318-25.
Cunningham F, Leveno K, Bloom S, Hauth J, Gilstrap L, Rouse D, et al. Fetal growth disorders. Williams Obstetrics. 26th edition. New York, McGraw Hill Professionals. 2022;879-997.
Committee on Practice Bulletins Obstetrics. "Practice Bulletin No. 181: Prevention of Rh D Alloimmunization". Am J Obstet Gynecol. 2017;130(2):e57-7.
Moise KJ. Red cell Alloimmunization. Gabbe, Obstetrics Essentials: Normal and Problem Pregnancies. 7th edition. Elsevier. 2019;585-95.
Bhutani VK, Zipursky A, Blencowe H, Khanna R, Sgro M, Ebbesen F, et al. Neonatal hyperbilirubinemia and Rhesus disease of the newborn: incidence and impairment estimates for 2010 at regional and global levels. Pediatr Res. 2013;74(Suppl 1):86-100. DOI: https://doi.org/10.1038/pr.2013.208
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 75. Management of alloimmunization during pregnancy. Obstet Gynecol. 2006;108(2):457-64. DOI: https://doi.org/10.1097/00006250-200608000-00044
American College of Obstetricians and Gynecologists. Practice Bulletin No. 181. Prevention of Rh D Alloimmunization. Obstet Gynecol. 2017;130(2):e57-e70. DOI: https://doi.org/10.1097/AOG.0000000000002232
Taylor JF. Sensitization of Rh-negative daughters by their Rh-positive mothers. N Engl J Med. 1967;276(10):547-51. DOI: https://doi.org/10.1056/NEJM196703092761004
Agarwal S, Najam R, Chowdhary HH. Prevalence of Rhesus Negative Pregnant Population at a Tertiary Care Hospital. Int J Sci Stud. 2015;2(11):67.
Tripathi R, Singh N. Maternal and perinatal outcome in Rh negative mothers, Int J Reprod Contracept Obstet Gynecol. 2023;12(12):3479-83. DOI: https://doi.org/10.18203/2320-1770.ijrcog20233621
Preethi IS, Sravani K, Anuradha K. Rh negative complicating pregnancy Prevalance, Maternal and Foetal Outcome inn GGH Guntur. IOSR J Dent Med Sci. 2019;19:12-5.
Shradha, Moitra B, Kumari A, Sahay PB. Obstetrical and Perinatal Outcome in Rhesus Antigen Negative Pregnancy. Int J Sci Study. 2016;3(11):124-9.
Alakananda, Das M, Paul M. Rhesus Negative Mother and Perinatal Outcome. Sch Int J Obstet Gynec. 2019;2(11):284-7. DOI: https://doi.org/10.36348/sijog.2019.v02i11.006
Bowman JM. The prevention of Rh immunization. Transfus Med Rev. 1988;2:129. DOI: https://doi.org/10.1016/S0887-7963(88)70039-5
Chintada H, Bai B. Maternal and perinatal outcome in rhesus antigen negative pregnancy. IAIM. 2020;7(11):8-14.
Downloads
Published
How to Cite
Issue
Section
