Uterine carcinosarcomas case series of rare uterine malignancy

Authors

  • Jitendra Patel Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India
  • Punita Pant Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India
  • Balaji Shewalkar Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India
  • Dhiraj Meshram Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20250995

Keywords:

Carcinosarcoma, Biphasic, Treatment, Rare neoplasia

Abstract

Primary malignant mixed Müllerian tumor (MMMT) of the ovary is a rare and highly aggressive neoplasm predominantly affecting postmenopausal women. MMMT is a biphasic tumor comprising both epithelial and mesenchymal components and is associated with significantly higher mortality compared to epithelial ovarian neoplasms. Patients typically present with symptoms such as vaginal bleeding, abdominal pain, and a palpable mass. Surgery remains the primary treatment modality, while adjuvant therapies, including chemotherapy and radiotherapy, play a crucial role in improving locoregional control and managing distant metastasis. Due to the rarity of these tumors, there is limited literature on their optimal therapeutic management. This series aims to analyse the clinical presentations and treatment outcomes of patients diagnosed with this uncommon uterine cancer treated at our hospital.

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Author Biographies

Jitendra Patel, Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India

ASSOCIATE PROFFESOR, RADIATION ONCOLOGY, STATE CANCER INSTITUTE, CHHATRAPATI SAMBHAJI NAGAR, MAHARASHTRA

Punita Pant, Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India

ASSOCIATE PROFFESOR, RADIATION ONCOLOGY, STATE CANCER INSTITUTE, CHHATRAPATI SAMBHAJI NAGAR, MAHARASHTRA-431001

Balaji Shewalkar, Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India

HEAD OF DEPARTMENT, RADIATION OCOLOGY, STATE CANCER INSTITUTE, CHHATRAPATI SAMBHAJI NAGAR, MAHARASHTRA

Dhiraj Meshram, Department of Radiation Oncology, GMCCH, Chhatrapati Sambhaji Nagar, Maharashtra, India

RESIDENT, RADIATION ONCOLOGY, STATE CANCER INSTITUTE, CHHATRAPATI SAMBHAJI NAGAR, MAHARASHTRA

References

El-Nashar SA, Mariani A. Uterine carcinosarcoma. Clin Obstetr Gynecol. 2011;54(2):292-304. DOI: https://doi.org/10.1097/GRF.0b013e31821ac635

Grayson W, Taylor LF, Cooper K. Carcinosarcoma of uterine cervix: a report of eight cases with immunohistochemical analysis and evaluation of human papillomavirus status. Am J Surg Pathol. 2001;25(3):338-47.

Kounelis S, Jones MW, Papadaki H, Bakker A, Swalsky P, Finkelstein SD. Carcinosarcomas (malignant mixed mullerian tumors) of the female genital tract: comparative molecular analysis of epithelial and mesenchymal components. Hum Pathol. 1998;29(1):82-7. DOI: https://doi.org/10.1016/S0046-8177(98)90394-X

Tanaka YO, Tsunoda H, Minami R, Yoshikawa H, Minami M. Carcinosarcoma of the uterus: MR findings. J Magnetic Resonance Imaging. 2008;28(2):434-9. DOI: https://doi.org/10.1002/jmri.21469

Mok JE, Kim YM, Jung MH, Kim KR, Kim DY, Kim JH, et al. Mixed Mullerian Tumors of the Ovary: Experience with Cytoreductive Surgery and Platinum-Based Combination Chemotherapy. Int J Gynarcol Cancer. 2006;16(1):101-5. DOI: https://doi.org/10.1111/j.1525-1438.2006.00281.x

Sreenan JJ, Hart WR. Carcinosarcomas of the female genital tract. A pathologic study of 29 metastatic tumors: further evidence for the dominant role for the epithelial component and the conversion theory of histogenesis. Am J Surgical Pathol. 1995;19(6):666-74. DOI: https://doi.org/10.1097/00000478-199506000-00007

Jin Z, Ogata S, Tamura G. Carcinosarcomas (malignant mullerian mixed tumors) of the uterus and ovary: a genetic study with special reference to histogenesis. Int J Gynecolog Pathol. 2003;22(4):368-73. DOI: https://doi.org/10.1097/01.pgp.0000092134.88121.56

Grayson W, Taylor LF, Cooper K. Carcinosarcoma of uterine cervix: a report of eight cases with immunohistochemical analysis and evaluation of human papillomavirus status. Am J Surg Pathol. 2001;25(3):338-47. DOI: https://doi.org/10.1097/00000478-200103000-00008

Raspollini MR, Susini T, Amunni G, Milena P, Antonio T, Mauro M, et al. COX-2, c-KIT and HER-2/neu expression in uterine carcinosarcomas: prognostic factors or potential markers for targeted therapies? Gynecol Oncol. 2005;96(1):159-67. DOI: https://doi.org/10.1016/j.ygyno.2004.09.050

Sawada M, Tsuda H, Kimura M, Okamoto S, Kita T, Kasamatsu T, et al. Different expression patterns of KIT, EGFR, and HER-2 (c-erbB-2) oncoproteins between epithelial and mesenchymal components in uterine carcinosarcoma. Cancer Sci. 2003;94(11):986-91. DOI: https://doi.org/10.1111/j.1349-7006.2003.tb01389.x

Swisher EM, Gown AM, Skelly M, Ek M, Tamimi HK, Cain JM, et al. The expression of epidermal growth factor receptor, HER-2/Neu, p53, and Ki-67 antigen in uterine malignant mixed mesodermal tumors and adenosarcoma. Gynecologic Oncol. 1996;60(1):81-8. DOI: https://doi.org/10.1006/gyno.1996.0015

Vorgias G, Fotiou S. The role of lymphadenectomy in uterine carcinosarcomas (malignant mixed mullerian tumours): a critical literature review. Arch Gynecol Obstetr. 2010;282(6):659-64. DOI: https://doi.org/10.1007/s00404-010-1649-0

Brown L. Pathology of uterine malignancies. Clin Oncol. 2008;20(6):433-47. DOI: https://doi.org/10.1016/j.clon.2008.04.005

Homesley HD, Filiaci V, Markman M, Pincas B, Lynne E, Larry CK, et al. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a gynecologic oncology group study. J Clin Oncol. 2007;25(5):526-31. DOI: https://doi.org/10.1200/JCO.2006.06.4907

Powell MA, Filiaci VL, Rose PG, Mannel RS, Hanjani P, DeGeest K, et al. Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: a gynecologic oncology group study. J Clin Oncol. 2010;28(16):2727-31. DOI: https://doi.org/10.1200/JCO.2009.26.8326

Gunther JR, Christensen EN, Allen PK, Ramondetta LM, Jhingran A, Fleming ND, et al. Role of Radiation Therapy in the Multidisciplinary Management of Uterine Carcinosarcoma. Int J Gynecol Cancer. 2018;28(1):114-21. DOI: https://doi.org/10.1097/igc.0000000000001135

Bosquet JS, Terstriep SA, Cliby WA, Brown-Jones M, Kaur JS, Podratz KC, et al. The impact of multimodal therapy on survival for uterine carcinosarcoma Gynec Oncol. 2010;116(3):419-23. DOI: https://doi.org/10.1016/j.ygyno.2009.10.053

Ferguson SE, Tornos C, Hummer A, Barakat RR, Soslow RA. Prognostic features of surgical stage I uterine carcinosarcoma. Am J Sur Pathol. 2007;31(11):1653-61. DOI: https://doi.org/10.1097/PAS.0b013e3181161ba3

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Published

2025-03-29

How to Cite

Patel, J., Pant, P., Shewalkar, B., & Meshram, D. (2025). Uterine carcinosarcomas case series of rare uterine malignancy. International Journal of Research in Medical Sciences, 13(4), 1646–1653. https://doi.org/10.18203/2320-6012.ijrms20250995

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Section

Case Series