Takayasu’s arteritis: a diagnostic dilemma

Authors

  • Sukhdeep Kaur Department of Pediatrics, GGSMCH, Faridkot, Punjab, India
  • Avneet Kaur Department of Pediatrics, GGSMCH, Faridkot, Punjab, India
  • Aditi Sharma Department of Radiodiagnosis, GGSMCH, Faridkot, Punjab, India
  • Seema Rai Department of Pediatrics, GGSMCH, Faridkot, Punjab, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20251335

Keywords:

Hypertension, Vascultis, Inflammation, Headache, Hyperkalaemia

Abstract

Takayasu`s arteritis is an uncommon form of chronic vasculitis that primarily affects medium and large blood vessels, including the aorta and its major branches. The disease is mainly seen in young women. This is marked by mononuclear cell infiltration and granulomatous inflammation within the vascular media. These pathological changes result in thickening of the arterial wall, which can lead to stenosis, occlusion, or the formation of aneurysms. It can lead to severe complications such as stroke, ischaemic heart disease, pulmonary hypertension, secondary hypertension and aneurysm formation. Here we present a case of Takayasu`s arteritis in a 10-year-old girl who presented with low grade fever, headache and systemic hypertension with thickened walls of left subclavian artery and left renal artery in computed tomography angiogram. Early diagnosis and prompt treatment are crucial for managing Takayasu`s arteritis. When the disease is in a dormant phase, the prognosis tends to be more favourable.

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References

Sanchez-Alvarez C, Crowson CS, Koster MJ, Warrington KJ. Prevalence of Takayasu arteritis: A population-based study. J Rheumatol. 2021;48(6):952. DOI: https://doi.org/10.3899/jrheum.201463

Onen F, Akkoc N. Epidemiology of Takayasu arteritis. Presse Med. 2017;46:e197-203. DOI: https://doi.org/10.1016/j.lpm.2017.05.034

Szugye HS, Zeft AS, Spalding SJ. Takayasu arteritis in the paediatric population: a contemporary United States-based single center cohort. Paediatr Rheumatol Online J. 2014;12:21. DOI: https://doi.org/10.1186/1546-0096-12-21

Sahin S, Hopurcuoglu D, Bektas S, Belhan E, Adrovic A, Barut K, et al. Childhood-onset Takayasu arteritis: a 15-year experience from a tertiary referral center. Int J Rheum Dis. 2019;22:132-9. DOI: https://doi.org/10.1111/1756-185X.13425

Inder SJ, Bobryshev YV, Cherian SM, Wang AY, Lord RS, Masuda K, et al. Immunophenotypic analysis of the aortic wall in Takayasu's arteritis: involvement of lymphocytes, dendritic cells and granulocytes in immuno-inflammatory reactions. Cardiovasc Surg. 2000;8(2):141-8. DOI: https://doi.org/10.1177/096721090000800210

Daryani NE, Habibi AN, Bashashati M, Keramati MR, Rafiee MJ, Ajdarkosh H, et al. Takayasu's arteritis associated with Crohn's disease: A case report. J Med Case Rep. 2008;2:87. DOI: https://doi.org/10.1186/1752-1947-2-87

Khadka A, Singh S, Timilsina S. Takayasu's Arteritis: A Case Report. JNMA J Nepal Med Assoc. 2022;60(256):1041-4. DOI: https://doi.org/10.31729/jnma.7685

AS Danda, D. Current Diagnosis and Management of Takayasu Arteritis. Int Heart J. 2023;64:519-34. DOI: https://doi.org/10.1536/ihj.23-195

Moisii P, Jari I, Naum AG, Butcovan D, Tinica G. Takayasu's Arteritis: A Special Case Report and Review of the Literature. Medicina (Kaunas). 2024;60(3):456. DOI: https://doi.org/10.3390/medicina60030456

Almaaitah S, Zhang C, Villa Forte A. The utility of imaging studies (MRA and CTA) in long-term monitoring for patients with Takayasu arteritis. Arth Rheumatol. 2022;74(S9):1551.

Saadoun D, Bura-Riviere A, Comarmond C, Lambert M, Redheuil A, Mirault T. French recommendations for the management of Takayasu’s arteritis. Orphanet J Rare Dis. 2021;16:311. DOI: https://doi.org/10.1186/s13023-021-01922-1

Regola F, Uzzo M, Toniati P, Trezzi B, Sinico RA, Franceschini F. Novel Therapies in Takayasu Arteritis. Front Med (Lausanne). 2022;8:814075. DOI: https://doi.org/10.3389/fmed.2021.814075

van der Heijde D, Aletaha D, Carmona L, Edwards CJ, Kvien TK, Kouloumas M, et al. 2014 Update of the EULAR standardised operating procedures for EULAR-endorsed recommendations. Ann Rheum Dis. 2015;74(1):8-13. DOI: https://doi.org/10.1136/annrheumdis-2014-206350

Takayasu, M. A case with peculiar changes of the retinal central vessels. Acta Soc Ophtal Jpn. 1908;12:554-5.

Poignet B, Bonnin P, Gaudric J, Chehaibou I, Vautier M, Tadayoni R, et al. Correlation between Ultra-Wide-Field Retinal Imaging Findings and Vascular Supra-Aortic Changes in Takayasu Arteritis. J Clin Med. 2021;10(21):4916. DOI: https://doi.org/10.3390/jcm10214916

Belem JMFM, Pereira RMR, Perez MO, do Prado LL, Calich AL, Sachetto Z, et al. Epidemiologic features of systemic vasculitides in the Southeast region of Brazil: Hospital-based survey. J Clin Rheumatol. 2020;26(7S Suppl 2):S106-10. DOI: https://doi.org/10.1097/RHU.0000000000001041

Li L, Zhou F, Li F, Chen J, Xie X. Prevalence of tuberculosis infection among patients with Takayasu arteritis: a meta-analysis of observational studies. Sci Rep. 2023;13(1):22481. DOI: https://doi.org/10.1038/s41598-023-49998-y

Grayson PC, Ponte C, Suppiah R, Robson JC, Gribbons KB, Judge A, et al; DCVAS Study Group. 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis. Ann Rheum Dis. 2022;81(12):1654-60. DOI: https://doi.org/10.1002/art.42324

Mukhtyar C, Guillevin L, Cid MC, Dasgupta B, de Groot K, Gross W, et al; European Vasculitis Study Group. EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2009;68(3):318-23. DOI: https://doi.org/10.1136/ard.2008.088351

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Published

2025-04-29

How to Cite

Kaur, S., Kaur, A., Sharma, A., & Rai, S. (2025). Takayasu’s arteritis: a diagnostic dilemma. International Journal of Research in Medical Sciences, 13(5), 2192–2195. https://doi.org/10.18203/2320-6012.ijrms20251335

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Section

Case Reports