DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20150148

Comparative evaluation of screening tests for maternal and fetal outcome in gestational diabetes

Shivi Saxena, Arshiya Khan

Abstract


Background: We aimed to evaluate the predictive value of two screening tests - 50 gm GCT and 75 gm GTT for adverse maternal and fetal outcome in patients with gestational diabetes mellitus.

Methods: This was a prospective study of 200 antenatal women booked at tertiary care hospital Delhi during the year 2010-2012. Pregnant females at 24-28 weeks gestation were randomly selected and subjected to 50 gm GCT and 75 gm GTT. The women’s history, clinical examination recorded, 50 gm GCT and 75 gm GTT values recorded and the two tests were compared for maternal and fetal outcome.

Results: 75 gm GTT had higher specificity, positive and negative predictive values as compared to 50 gm GCT for both maternal and fetal outcome. However 50 gm GCT was more sensitive for predicting maternal and fetal complications.

Conclusions: 75 gm GTT is better than 50 gm GCT for predicting adverse maternal and perinatal outcome in gestational diabetic patients.

 


Keywords


Screening tests, Maternal and fetal outcome, GTT, Diabetic patients

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References


Metzer BE, Coustan DM. Organising committee summary and recommendation of fourth international workshop. Conference on Gestational Diabetes Mellitus. Diabetes Care. 1998;21(Suppl 2):B161-7.

Catalano PM, Kirwan JP, Haugel-de Mouzons, King J. Gestational diabetes and insulin resistance, role in short and long term implications for mother and fetus. J Nutr. 2003;133:16745-835.

Keith Edmonds. Diabetes and endocrine disease in pregnancy. In: Keith Edmonds, eds. Dewhurst Obstetrics and Gynaecology 7th ed. Oxford: Wiley-Blackwell; 2007: 248-254.

Schaefer UM, Songster G, Xiang A, Berkowitz K, Buchanan TA, Kjos SL. Congenital malformations in offspring of women with hyperglycemia first detected during pregnancy. Am J Obstet Gynaecol. 1997;177:1165-71.

Boyd E. Metzger, Thomas A. Buchanan, Donald R. Coustan, Alberto De Leiva, David B. Dunger, David R. Hadden, et al. Summary and recommendations of the fifth international workshop-conference on gestational diabetes mellitus. Diabetes Care. 2007;30(2):S251-60.

American College of Obstetricians and Gynaecologist Committee on Practice Bulletins - ACOG Practice Bulletin. Clinical Management Guidelines for Obstetrician - Gynaecologists. Number 30. Gestational diabetes. Obstet Gynaecol. 2011;98(3):525-38.

Mamta Bhat, K. N. Ramesha, Sankara P. Sarma, Sangeetha Menon, C. V. Sowmini, S. Ganesh Kumar. Study of gestational diabetes females in thiruvananthapuram. Int J Diabetes Dev Ctries. 2010;30(2):91-6.

Abdul Bari, Najah M. Saleh, Abdulla Al-Hamaq. Outcome of pregnancy complicated by gestational diabetes mellitus. Int J Women Health. 2011;3:367-73.

Jenson D, Sorensen B, Feilberg-Jørgensen N, Westergaard JG, Beck-Nielsen H. Maternal and perinatal outcome in 143 Danish women with gestational diabetes mellitus. Diabet Med. 2000;17:281-6.

Ostlund I, Hanson U, Björklund A, Hjertberg R, Eva N, Nordlander E, et al. Maternal and fetal outcome in gestational diabetes mellitus. Diabetes Care. 2003;26(7):2107-11.

De Sereday MS, Damiano MM, Gonzalez CD, Bennett PH. Diagnostic criteria for gestational diabetes in relation to pregnancy outcome. J Diabetes Complicat. 2003;(3):115-9.

Giorgiomello, Elena Parrettitri, Riccardo Cioni. 75 gm glucose load in pregnancy, relation between glucose levels and anthropometric characteristics of infants born to women with normal glucose metabolism. Diabetes Care. 2003;26(4):1206-10.

Rajesh R, Yadav Y, Nanda S, Rajput M. Prevalence of GDM in Haryana. Indian J Med Res. 2013 Apr;137:728-33.