Uterine rupture in a pregnancy without previous uterine scarring and induction of labor with misoprostol: a case report
DOI:
https://doi.org/10.18203/2320-6012.ijrms20251117Keywords:
Uterine rupture, Rare obstetric emergency, Labor, Uterine bleeding, Misoprostol, Hysterectomy, Fetal death, Risk factorsAbstract
Uterine rupture (UR) is a serious obstetric complications involving the uterine wall injury during pregnancy or delivery. It occurs in one in 5,000 to 7,000 births, with about up to 10% requiring hysterectomy. Risk factors include previous uterine scarring, use of uterotonics, induction of labor, history of uterine trauma, high multiparity, abnormal placentation, fetal abnormalities, advanced maternal age, a high body mass index (BMI), and lack of prenatal monitoring. A 36-year-old Mexican female with five previous pregnancies, all terminated by vaginal route, with poor prenatal monitoring and high blood pressure. Prostaglandin E1 (misoprostol 50 mcg) was used in two doses with the patient starting labor in an active phase, but presented moderate abdominal pain, no fetal heart rate, and weak transvaginal bleeding. A probable detachment of placenta and fetal death was suspected; therefore, it was decided to perform an emergency caesarean section. This case highlights the importance of obstetric care, particularly in relation to gestational hypertension, induction of labor, and severe complications as uterine rupture. In our patient misoprostol was used to prepare the cervix and promote induction of term delivery, but its administration led to uterine rupture. UR is a rare obstetric emergency that requires immediate attention and proper surgical management. It is more common in women with previous uterine scarring and can occur in a uterus without a surgical history. Risk factors and clinical monitoring are crucial for early warning signs. Misoprostol use should be adjusted based on patient characteristics and pre-existing factors. Timely diagnosis and treatment are essential to reduce morbidity and mortality.
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References
Almeida Arguello NA, Ballesteros Trillos JP. Reporte de caso: ruptura uterina durante trabajo de parto, en útero sin cicatriz previa. Medicas UIS. 2021;34(1):107-12. DOI: https://doi.org/10.18273/revmed.v34n1-2021011
Togioka BM, Tonismae T. Uterine Rupture. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2023.
Ibargüengoitia-Ochoa F, Miranda- Araujo O, López-Torres MF. Spontaneous and inadvertent uterine rupture. Case report. Gynecol Obstet Mex. 2023;91(11):857-60.
Sugai S, Yamawaki K, Haino K, Yoshihara K, Nishijima K. Incidence of Recurrent Uterine Rupture: A Systematic Review and Meta-analysis. Obstet Gynecol. 2023;142(6):1365-72. DOI: https://doi.org/10.1097/AOG.0000000000005418
Onstad SK, Miltenburg AS, Strøm-Roum EM. Uterine rupture in a nulliparous woman. Tidsskr Nor Laegeforen. 2021;20:141.
Finnsdottir SK, Maghsoudlou P, Pepin K, Gu X, Carusi DA, Einarsson JI, et al. Uterine rupture and factors associated with adverse outcomes. Arch Gynecol Obstet. 2022;308(4):1271-8. DOI: https://doi.org/10.1007/s00404-022-06820-w
Cecchini F, Tassi A, Londero AP, Baccarini G, Driul L, Xodo S. First Trimester Uterine Rupture: A Case Report and Literature Review. Int J Environ Res Public Health. 2020;17(8):2976. DOI: https://doi.org/10.3390/ijerph17082976
Dabi Y, Bouaziz J, Burke Y, Nicolas-Boluda A, Cordier AG, Chayo J, et al. Outcome of subsequent pregnancies post uterine rupture in previous delivery: A case series, a review, and recommendations for appropriate management. Int J Gynaecol Obstet. 2023;161(1):204-17. DOI: https://doi.org/10.1002/ijgo.14445
Figueiró-Filho EA, Gomez JM, Farine D. Risk Factors Associated with Uterine Rupture and Dehiscence: A Cross-Sectional Canadian Study. Rev Bras Ginecol Obstet. 2021;43(11):820-5. DOI: https://doi.org/10.1055/s-0041-1739461
Taliento C, Manservigi M, Tormen M, Cappadona R, Piccolotti I, Salvioli S, et al. Safety of misoprostol vs dinoprostone for induction of labor: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2023;289:108-28. DOI: https://doi.org/10.1016/j.ejogrb.2023.08.382
Yamamoto A, Jn-Charles P. Uterine rupture with induction using misoprostol for intrauterine foetal death in the second trimester: A case report. Case Rep Womens Health. 2024;44:e00671. DOI: https://doi.org/10.1016/j.crwh.2024.e00671
Gonzalez ER, Arroyo AMH, Benasach FG, Conde TG. Hypertensive states of pregnancy. Hypertens Vasc Risk. 2024;41(2):118-31. DOI: https://doi.org/10.1016/j.hipert.2023.11.006
Kumar N, Haas DM, Weeks AD. Misoprostol for labour induction. Best Pract Res Clin Obstet Gynaecol. 2021;77:53-63. DOI: https://doi.org/10.1016/j.bpobgyn.2021.09.003
Kerr RS, Kumar N, Williams MJ, Cuthbert A, Aflaifel N, Haas DM, et al. Low-dose oral misoprostol for induction of labour. Cochrane Database Syst Rev. 2021;6(6):CD014484. DOI: https://doi.org/10.1002/14651858.CD014484
Sanchez-Ramos L, Levine LD, Sciscione AC, Mozurkewich EL, Ramsey PS, Adair CD, et al. Methods for the induction of labor: efficacy and safety. Am J Obstet Gynecol. 2024;230(3S):S669-95. DOI: https://doi.org/10.1016/j.ajog.2023.02.009
Abdulmane MM, Sheikhali OM, Alhowaidi RM, Qazi A, Ghazi K. Diagnosis and Management of Uterine Rupture in the Third Trimester of Pregnancy: A Case Series and Literature Review. Cureus. 2023;15(6):e39861. DOI: https://doi.org/10.7759/cureus.39861
Al-Zirqi I, Daltveit AK, Vangen S. Maternal outcome after complete uterine rupture. Acta Obstet Gynecol Scand. 2019;98(8):1024-31. DOI: https://doi.org/10.1111/aogs.13579
Federspiel JJ, Eke AC, Eppes CS. Postpartum hemorrhage protocols and benchmarks: improving care through standardization. Am J Obstet Gynecol MFM. 2023;5(2S):100740. DOI: https://doi.org/10.1016/j.ajogmf.2022.100740