Pattern of lymphadenopathy in fine needle aspiration cytology: a retrospective study
Background: Lymphadenopathy is of great clinical significance as underlying disease may range from treatable infectious etiology to malignant neoplasm. In fact it is also essential to establish that swelling in question is lymph node. Incidence of lymphadenopathy appears to be increasing especially among young adults all over the world. Inflammatory and immune reaction are most frequent cause of lymph node enlargement and are self limiting in majority of cases. Lymphnode are also affected as a result of primary neoplasm or from metastasis of malignant neoplasm from regional and distant organ.
Aims: Study different cytomorphological patterns associated with various lymphadenopathy and spectrum of lesion with respect to age and sex.
Methods: A total of 1774 cases came for FNAC of lymphnode in the Department of Pathology, MMC & RI, MYSORE from NOV 2011 to OCT 2014 were retrieved and studied retrospectively.
Results: Out of total cases, 908 were males and 865 females with age range from 3mth to 90 years with maximum number of cases diagnosed with reactive lymphadenopathy (26.2%) followed by metastatic lymphadenopathy (21.2%), Non specific lymphadenitis (18.5%), granulomatous lymphadenitis (14.65%), tuberculous lymphadenitis (14.65%), suppurative lymphadenitis (3.94%) and lymphoma(0.73%).
Conclusion: FNAC recognized as a diagnostic technique because of simplicity, cost effectiveness, easily availability of results, accuracy and minimal invasion. With the advent of FNAC most of inflammatory, reactive and neoplastic condition can be diagnosed without biopsy.
Mohanty R, Wilkinson A.Utility of Fine Needle Aspiration Cytology of Lymph Nodes. IOSR-JDMS 2013; 8 :13-18.
Hirachand S, Lakhey M, Akhter J, Thapa B. Evaluation of Fine Needle Aspiration Cytology of Lymph Nodes in Kathmandu Medical College Teaching Hospital. Kathmandu University Medical Journal 2009; 7:139-142.
Kochhar K, Patel B, Shah M. Pattern of Lymphadenopathy on Fine Needle Aspiration Cytology of Superficial Lymph Nodes (A Study of 150 Cases). JARBS 2012; 4: 288-292.
Khajuria R, Goswami KC, Singh K, Dubey VK. Pattern of Lymphadenopathy on Fine Needle Aspiration cytology in Jammu. JK Science Journal of Medical Education and Research 2006; 8:157-159.
Adhikari P, Sinha BK, Baskota DK. Comparison of fine needle aspiration cytology and histopathology in diagnosing cervical lymphadenopathies. AMJ 2011; 4: 97-99.
Paul PC, Goswami BK, Chakrabarti S, Giri A, Pramanik R. Fine Needle Aspiration Cytology of Lymph Nodes - An institutional study of 1448 cases over a five year period. Journal of Cytology 2004; 21:187-90.
Ahmad T, Naeem M, Ahmad S, Samad A, Nasir A. Fine Needle Aspiration Cytology (FNAC) and Neck swellings in the surgical department. Journal of Ayub Medical College Abbottabad 2008; 20:30.
Sarwar A, Haque A, Aftab S, Mustafa M, Moatasim A, Siddique S et al. Spectrum of Morphological Changes in Tuberculous Lymphadenitis. International Journal of Pathology 2004; 2:85-89.
Alam K, Khan AH, Siddiqui FA, Jain A, Haider N. Fine Needle Aspiration Cytology (FNAC), a handy tool for metastatic lymphadenopathy. The Internet Journal of Pathology 2010;10. Available from: http://www.ispub.com/journal/the_internet_journal_of_pathology.
Bhagwan IN, Kane SV, Chinoy RF. Cytologic Evaluation of the Enlarged Neck Node: FNAC Utility in Metastatic Neck Disease. The Internet Journal of Pathology 2007; 6. Available from: http://www.ispub.com/journal/the_internet_journal_of_pathology.
Haque MA, Talukder SI: Evaluation of fine needle aspiration cytology (FNAC) of lymphnodes in Mymensingh. Mymensingh Med J 2003; 12:33-5.
Ghartimagar D, Ghosh A, Ranabhat S, Shrestha MK, Narasimhan R, Talwar OP. Utility of fine needle aspiration cytology in metastatic lymph nodes. Journal of Pathology of Nepal 2011; 1: 92-95.
Martin MR, Santos GC. Fine Needle Aspiration Cytology in the diagnosis of superficial lymphadenopathy: a 5 year Brazilian experience. Diagn Cytopathol 2006; 34:130-134.
Hafez NH, Tahoun NS. Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy. Journal of the Egyptian National Cancer Institute 2011; 23: 105–114.
Hoftr S, Muhle C, Brenner W, Sprenger E, Maune S. Fine-Needle Aspiration Cytology of the Sentinel Lymph Node in Head and Neck Cancer. J Nucl Med 2002; 43:1585–90.
Mitra S, Ray S, Mitra PK. Fine needle aspiration cytology of supraclavicular lymph nodes: our experience over a three year period. J Cytol 2011; 28: 108–110.
Mohan A,Reddy KM,Phaneendra BV,Chandra A.Aetiology of peripheral lymphadenopathy in adults.The National Medical journal of India 2007;20:78-80.
Chawla N,Kishore S,Kudesia S.FNAC of lymph node disorder.India Medical Gazette 2012;312-315.