Clinico-social profile of adult patients with uncontrolled seizures attending a neurology OPD at a tertiary care hospital in Goa

Authors

  • Nevin Z. Mathews Department of Neurology, Goa Medical College, Bambolim, Goa, India
  • Nadia C. M. e Dias Department of Community Medicine, Goa Medical College, Bambolim, Goa, India
  • Teresa Ferreira Department of Neurology, Goa Medical College, Bambolim, Goa, India
  • Sanat R. Bhatkar Department of Neurology, Goa Medical College, Bambolim, Goa, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20251644

Keywords:

Epilepsy, Seizures, AEDs, Poor-compliance, Goa

Abstract

Background: Of the 70 million persons with epilepsy (PWE) worldwide, nearly 12 million PWE are expected to reside in India. Nearly one-third of the patients with newly diagnosed epilepsy on long-term follow-up will have their seizures unsatisfactorily controlled by treatment with available anti-epileptic drugs (AEDs). Objective of this study was to study the clinico-social profile of adult patients with uncontrolled seizures.

Methods: A cross-sectional study was conducted over a period of 3 months among 106 patients with uncontrolled seizures. Universal sampling was used to select the participants, and a semi-structured questionnaire was used to collect the data.

Results: Poor compliance to medication was the most common cause for uncontrolled seizures (51.8%) and was significantly associated with those who were prescribed <3 AEDs (OR=2.532, p=0.041). Focal with impaired awareness (34.9%) and generalised tonic clonic seizures (GTCS) (34.9%) were the most commonly seen.

Conclusions: Patient compliance is of utmost importance in maintaining good seizure control.

Metrics

Metrics Loading ...

References

Huff JS, Murr NI. Seizure. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2024 Available at: http://www.ncbi.nlm.nih.gov/books/NBK430765/. Accessed on 28 July 2024.

Drug Resistant Epilepsy. Epilepsy Foundation. Available at: https://www.epilepsy.com/treatment/medicines/drug-resistant-epilepsy. Accessed on 28 July 2024.

Engel J. Epilepsy: a comprehensive textbook. (No Title). Available at: https://cir.nii.ac.jp/crid/1130000793923101440. Accessed on 28 July 2024.

Amudhan S, Gururaj G, Satishchandra P. Epilepsy in India I: Epidemiology and public health. Ann Indian Acad Neurol. 2015;18(3):263-77. DOI: https://doi.org/10.4103/0972-2327.160093

Santhosh NS, Sinha S, Satishchandra P. Epilepsy: Indian perspective. Ann Indian Acad Neurol. 2014;17(Suppl 1):S3-11. DOI: https://doi.org/10.4103/0972-2327.128643

Epilepsy. Available at: https://www.who.int/news-room/fact-sheets/detail/epilepsy. Accessed on 04 September 2023.

Asadi-Pooya AA, Emami M, Ashjazadeh N, Nikseresht A, Shariat A, Petramfar P, et al. Reasons for uncontrolled seizures in adults; the impact of pseudointractability. Seizure. 2013;22(4):271–4. DOI: https://doi.org/10.1016/j.seizure.2013.01.010

Mishra A, Borle AL. Updated B. G. Prasadf Scale for Socioeconomic Status Classification for the Year 2024. Indian J Pediatr. 2024;91(6):643-3. DOI: https://doi.org/10.1007/s12098-024-05131-z

Kaur S, Garg R, Aggarwal S, Chawla SPS, Pal R. Adult onset seizures: Clinical, etiological, and radiological profile. J Family Med Prim Care. 2018;7(1):191–7. DOI: https://doi.org/10.4103/jfmpc.jfmpc_322_16

Chauhan P, Philip SE, Chauhan G, Mehra S. The Anatomical Basis of Seizures. In: Czuczwar SJ, editor. Epilepsy. Brisbane (AU): Exon Publications; 2022. Available at: http://www.ncbi.nlm.nih.gov/books/NBK580614/. Accessed on 17 September 2023. DOI: https://doi.org/10.36255/exon-publications-epilepsy-anatomical-basis

Rao LM, Marcuccilli CJ. Seizures in the Preterm Neonate. Neo Reviews. 2017;18(1):e52–9. DOI: https://doi.org/10.1542/neo.18-1-e52

Panayiotopoulos CP. Clinical Aspects of the Diagnosis of Epileptic Seizures and Epileptic Syndromes. In: The Epilepsies: Seizures, Syndromes and Management. Bladon Medical Publishing; 2005. Available at: https://www.ncbi.nlm.nih.gov/books/NBK2609/. Accessed on 05 September 2024.

Kafle DR, Oli KK. Clinical profile of patients with recurrent seizure in tertiary care hospital in Nepal. Kathmandu Univ Med J (KUMJ). 2014;12(47):202-6. DOI: https://doi.org/10.3126/kumj.v12i3.13719

Nobili L, Beniczky S, Eriksson SH, Romigi A, Ryvlin P, Toledo M, et al. Expert Opinion: Managing sleep disturbances in people with epilepsy. Epilepsy Behav. 2021;124:108341. DOI: https://doi.org/10.1016/j.yebeh.2021.108341

Marouf H, Mohamed LA, El Ftatary A, Gaber DE. Prevalence and risk factors associated with drug-resistant epilepsy in adult epileptic patients. The Egypt J Neurol Psychiatry Neurosur. 2023;59(1):153. DOI: https://doi.org/10.1186/s41983-023-00750-3

Elmi AM, Ibrahim AA, Hassan MS, Osman FAO, Çelik C, Dirie AM, et al. Magnetic Resonance Imaging Findings and Their Association with Electroencephalographic Data in Children with Epilepsy at Tertiary Care Hospital in Mogadishu Somalia. IJGM. 2024;17:253-61. DOI: https://doi.org/10.2147/IJGM.S448291

MRI-identified pathology in adults with new-onset seizures. Neurol. Available at: https://www.neurology.org/doi/10.1212/WNL.0b013e3182a35193. Accessed on 05 September 2024.

Winston GP, Micallef C, Kendell BE, Bartlett PA, Williams EJ, Burdett JL, et al. The value of repeat neuroimaging for epilepsy at a tertiary referral centre: 16 years of experience. Epilepsy Res. 2013;105(3):349–55. DOI: https://doi.org/10.1016/j.eplepsyres.2013.02.022

What if the EEG is Normal? | Epilepsy Foundation. Available at: https://www.epilepsy.com/diagnosis/eeg/what-if-its-normal. Accessed on 05 September 2024.

Faught RE, Weiner JR, Guérin A, Cunnington MC, Duh MS. Impact of nonadherence to antiepileptic drugs on health care utilization and costs: findings from the RANSOM study. Epilepsia. 2009;50(3):501-9. DOI: https://doi.org/10.1111/j.1528-1167.2008.01794.x

Drug Resistant Epilepsy, Epilepsy Foundation. Available at: https://www.epilepsy.com/treatment/medicines/drug-resistant-epilepsy. Accessed on 05 September 2024.

Stafstrom CE, Carmant L. Seizures and Epilepsy: An Overview for Neuroscientists. Cold Spring Harb Perspect Med. 2015;5(6):a022426. DOI: https://doi.org/10.1101/cshperspect.a022426

Downloads

Published

2025-05-30

How to Cite

Mathews, N. Z., e Dias, N. C. M., Ferreira, T., & Bhatkar, S. R. (2025). Clinico-social profile of adult patients with uncontrolled seizures attending a neurology OPD at a tertiary care hospital in Goa. International Journal of Research in Medical Sciences, 13(6), 2510–2516. https://doi.org/10.18203/2320-6012.ijrms20251644

Issue

Section

Original Research Articles