DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20162911

A prospective study on prevalence and characteristics of hematologic effects associated with subclinical hypothyroidism

M. Kaleemullah Khan, Mohd Nasir Mohiuddin

Abstract


Background: Distinctive types of iron deficiency have been accounted for patients with obvious hypothyroidism with a predominance of up to 47%. Regardless of the fact that vitamin B12, folic corrosive and iron fixations are ordinary, weakness that standardizes in light of thyroxine substitution is found in up to 25% of hypothyroid patients.

Methods: Briefly, 50 women with SCH were enrolled in the study. Patients between 18 and 65 years old, with TSH levels more than 5.0 mIU/L, the patients selected has a history of hypothyroidism for more than a year and were on oral levothyroxine. A total of 50 participants were enrolled in the study. Blood samples were collected from 50 selected hypothyroid patients on the basis of a history of a hypothyroidism, persistent Anemia, of these patients all were females.

Results: In present study 25 cases of age group 41-65 years  there were almost 10 patients having high thyroid stimulating factor (Tsh) that is more than (0.3-5.0U/Ml), Constitute to be 40% cases in this age category. Hence patients with high age may slower the response towards a levothyroxine hormone and hence have the high risk of developing anemia.

Conclusions: Thyroid dysfunctions have an immediate impact on hemoglobin levels and these progressions should be considered in therapeutic consideration by medical practitioner.


Keywords


Hypothyroidism, Anemia, Iron deficiency

Full Text:

PDF

References


Christ-Crain M, Meier C, Huber P, Zulewski H, Staub JJ, Müller B. Effect of restoration of euthyroidism on peripheral blood cells and erythropoietin in women with subclinical hypothyroidism. Hormones. 2003;2(4):237-42.

Kazemi-Jahromi M, Shahriari-Ahmadi A, Samedanifard S, Doostmohamadian S, Abdolahpoor E, Allameh SF. The Association Between Hypothyroidism and Anemia: a Clinical Study. International Journal of Hematology- Oncology and Stem Cell Research. 2010;4(3):6-9.

Kammal M, Abdrabo AA. Assessment of thyroid hormone levels in Sudanese females with iron deficiency. Sudan Med J. 2014;50(2):98-102.

Sims EG. Hypothyroidism causing macrocytic anemia unresponsive to B12 and folate. J Natl Med Assoc. 1983;75(4):429-31.

Zaater MK. Iron Deficiency Anaemia and Thyroid Dysfunction by RIA. Med. J. Cairo Univ. 2012;80(1):307-12.

Zimmermann MB. The influence of iron status on iodin utilization and thyroid function. Annu. Rev. Nutr. 2006;26:367-89.

Akhter S, Nahar ZU, Parvin S, Alam A, Sharmin S, Arslan MI. Thyroid Status in Patients with Low Serum Ferritin Level, Bangladesh J Med Biochem. 2012;5(1):5-11.

Gökdeniz E, Demir C, Dilek I. The effects of iron deficiency anemia on the thyroid functions, ournal of Clinical and Experimental Investigations. 2010;1(3):156-60.

Dorgalaleh A, Mahmoodi M, Varmaghani B, Kiani node F, Saeeidi Kia O, Alizadeh Sh, et al. Effect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indice. Iranian Journal of Pediatric Hematology. Oncology. 2010;l3(2):73-7.

Goswami D, Brahma B, Ahmed AB, Sarma T, Choudhary B. A Case of Hashimoto’s Thyroiditis with Autoimmune Haemolytic Anaemia. Journal of Evidence based Medicine and Healthcare. 2014;1(14):1738-41.

Refaat B. Prevalence and characteristics of anemia associated with thyroid disorders in non-pregnant Saudi women during the childbearing age: A cross-sectional study. Biomed J. 2015;38(4):307-16.

Magalhaes S, Pinheiro DA, Souza MD, Pinheiro RF. The relationship between the thyroid hormone (or its lack) and dysplastic hematopoiesis. J Cancer Res Ther.2008;4(2):102-3.

Jain G, Goyal LK, Saxena GN. A Study to Evaluate Effect of Levothyroxine Supplementation in Iron Deficiency Anemia Patients having Subclinical Hypothyroidism Indian Journal of Applied Research. 2016;6(2).

Das C, Sahana PK, Sengupta N, Giri D, Roy M, Mukhopadhyay P. Etiology of anemia in primary hypothyroid subjects in a tertiary care center in Eastern India. Indian J Endocrinol Metab. 2012;16(Suppl 2):S361-3.