Histopathological insights into cherubism: a case presentation
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252046Keywords:
Cherubism, Fibro-osseous lesion, Multinucleated giant cells, Perivascular cuffingAbstract
Cherubism is a rare hereditary fibro-osseous disorder of the jaws, typically presents as progressive, painless, bilateral jaw swelling in children between 2 to 5 years of age, with lesions showing maximum growth until puberty before regressing spontaneously. Radiographically, it is characterized by bilateral, multilocular radiolucencies in the posterior mandible and maxilla. Histopathologically, cherubism is marked by fibrotic stromal proliferation with multinucleated osteoclast-like giant cells. The presence of vascular channels and eosinophilic deposits further accentuates the unique histologic landscape of this condition. By documenting this histopathological perspective, we aim to reinforce its diagnostic significance and contribute to the growing repository of cherubism-related literature.
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Choi Y, Ji JM, KiM CH, Sung KP. Surgical management of severe cherubism persisting into early adulthood: a case report and literature review. Arch Craniofac Surg. 2024;25(1):38-43. DOI: https://doi.org/10.7181/acfs.2023.00577
Jiao Y, Zhou M, Yang Y, Zhou J, Duan X. Cherubism misdiagnosed as giant cell tumor: a case report and review of literature. Int J Clin Experimental Med. 2015;8(3):4656.
Hamzavi SS, Askari A, Bahrololoom R, Mokhtari M, Sanaei Dashti A, Yarmahmoodi F, et al. Nonfamilial cherubism in a 6-month-old infant: a case report. BMC Pediatr. 2024;24(1):402. DOI: https://doi.org/10.1186/s12887-024-04825-9
Ram SG, Ajila V, Babu SG, Shetty P, Hegde S, Pillai DS. Cherubism: report of a case. Journal of Health and Allied Sciences NU. 2021;11(02):104-6. DOI: https://doi.org/10.1055/s-0040-1722425
Akolkar S, Hande A, Sonone AM, Chavhan A, Tehzeeb H. Cherubism Unmasked: A Case Report of Clinical and Histopathological Presentation. Cureus. 2024;16(3):e56456. DOI: https://doi.org/10.7759/cureus.56456
Pachva A, Narella K, Reddy AA, Kuar SP. Not All Chubby Cheeks Are Cute: A Case of Cherubism. Cureus. 2024;16(7):e65841. DOI: https://doi.org/10.7759/cureus.65841
Karthikeyan N, Varma S, Nagendran N, Moorthy P, Cheppala Rajan S. A rare case report of non-familial cherubism. J Evol Med Dent Sci. 2020;9:3503-5. DOI: https://doi.org/10.14260/jemds/2020/767
Papadaki ME, Lietman SA, Levine MA, Olsen BR, Kaban LB, Reichenberger EJ. Cherubism: best clinical practice. Orphanet J Rare Dis. 2012;7(1):1-4. DOI: https://doi.org/10.1186/1750-1172-7-S1-S6
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