Study of the prescribing pattern for antihypertensive drugs used in pregnancy at a tertiary care center
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252389Keywords:
Antihypertensive drugs, Pregnancy, Hypertension, PrescriptionsAbstract
Background: One of the most common health problems encountered during pregnancy is hypertension, which remains to be an important factor to the morbidity and death of both the mother and the fetus. The aim of the study was to examine the antihypertensive medication prescribing practices in tertiary care hospital.
Methods: This cross-sectional observational study involved 150 prescriptions written for pregnant women with primary essential hypertension at the Geetanjali medical college and hospital's gynecology inpatient department in Udaipur, Rajasthan. This study was conducted over six months of period enlisting 150 patients. Pregnant woman of more than 18 years of age and diagnosed with hypertension during pregnancy were willing to participate in the study were included.
Results: Out of 150 patients, the mean age of the patients was 29.97±5.59 years; with a minimum age of 18 years. Among them 13% were from 1st trimester, 9% were from 2nd trimester and 78% were from 3rd trimester. The prescribing pattern of antihypertensive drugs includes monotherapy and combinations therapy. In the current research, the prescribing pattern of antihypertensive drugs was based on the efficacy and safety profile in the pregnancy.
Conclusions: According to the current study, the safest treatment for hypertensive urgency and chronic hypertension is a tablet containing labetalol and magnesium sulphate (MgSO4). If the hypertension is detected in the early stages of pregnancy are treated with less medication.
Metrics
References
Kauntiz AM, Hughes JM, Grimes DH, Smith JC, Rochat RW, Kaffrissen ME. Causes of maternal mortality in the United States. Obstetr Gynecol. 1985;65(5):605-12.
NA. National High Blood Pressure Education Program Working Group Report on High Blood Pressure in Pregnancy. Am J Obstetr Gynecol. 1990;163:1689-712. DOI: https://doi.org/10.1016/0002-9378(90)90653-O
Folic M, Folic N, Varjacic M, Jakovljevic M, Jankovic S. Antihypertensive drug therapy for hypertensive disorders in pregnancy. Acta Medica Medianae. 2008;47(3):67-71.
Kanafileskookalayeh S, Bhojan C, Askari Mirzaei ES, Siby E. Study on Prescribing Pattern of Antihypertensives in Pregnancy at a Tertiary Care Teaching Hospital, India. Arch Pharmacy Pract. 2020;11(S4):37-40.
Easterling T, Mundle S, Bracken H, Parvekar S, Parvekar S, Mool S, Magee LA, et al. Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomized controlled trial. The Lancet. 2019;394(10203):1011-21. DOI: https://doi.org/10.1016/S0140-6736(19)31282-6
Jabeen M, Yakoob MY, Imdad A, Bhutta Z. A. Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths. BMC Pub Health. 2011;11(S3):S6. DOI: https://doi.org/10.1186/1471-2458-11-S3-S6
Tooher J, Thornton C, Makris A, Ogle R, Korda A, Hennessy A. All hypertensive disorders of pregnancy increase the risk of future cardiovascular disease. Hypertension. 2017;70(4):798-803. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.117.09246
Kiran Z, Sheikh A, Malik S, Meraj A, Meraj A, Masood M, Ismail S, et al. Maternal characteristics and outcomes affected by hypothyroidism during pregnancy (maternal hypothyroidism on pregnancy outcomes, MHPO-1). BMC Pregnancy Childbirth. 2019;19(1):1-2. DOI: https://doi.org/10.1186/s12884-019-2596-9
Anderson PO. Treating hypertension during breastfeeding. Breastfeeding Med. 2018;13(2):95-6. DOI: https://doi.org/10.1089/bfm.2017.0236
Clivaz Mariotti L, Saudan P, Landau Cahana R, Pechère-Bertschi A. Hypertension in pregnancy. Rev Med Suisse. 2007;3(124):2012-21. DOI: https://doi.org/10.53738/REVMED.2007.3.124.2012
Magee LA. Antihypertensives. Best Pract Res Clin Obstet Gynaecol. 2001;15(6):827-45. DOI: https://doi.org/10.1053/beog.2001.0232
American College of Obstetricians and Gynecologists. Clinical Management Guidelines for Obstetrician-Gynecologists Gestational Hypertension and Preeclampsia. ACOG Pract. Bull. No. 2020;222(135):e237-60. DOI: https://doi.org/10.1097/AOG.0000000000003891
Lowe SA, Brown MA, Dekker GA, Gatt S, McLintock CK, McMahon LP, et al. Guidelines for the management of hypertensive disorders of pregnancy 2008. Aust N Z J Obstet Gynaecol. 2009;49(3):242-6. DOI: https://doi.org/10.1111/j.1479-828X.2009.01003.x
Say L, Chou D, Gemmill A, Tunçalp Ö, Tunçalp O, Moller AB, Daniels J, et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Health. 2014;2(6):E323-33. DOI: https://doi.org/10.1016/S2214-109X(14)70227-X
Liu X, Ruan Y, Liu Y, Zhang W. Relationship between maternal age and hypertensive disorders in pregnancy. Zhonghua Yi Xue Za Zhi. 2015;95(1):19-22.