Adolescent cocaine use, immature brain, and health consequences
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252055Keywords:
Adolescent, Adolescent health, Cocaine, Crack, Psychoactive drugsAbstract
The use of psychoactive substances is a global public health problem that affects a great number of adolescents and young adults, also causing social, legal and economic consequences. Among the various psychoactive substances used in this age group, cocaine stands out, as it has a high potential for abuse and dependence and compromises the entire organism, mainly causing cognitive, emotional and behavioral changes. Adolescence is a phase of life in which physical, emotional, neurobiological and social changes are observed. It is a period of great plasticity of the brain and development of cognitive capacity, which makes adolescents vulnerable to the use/abuse of psychoactive substances and their harm. The use of cocaine during this period can cause interference in neural circuits, synaptic plasticity and neurotransmitter systems, causing lasting behavioral and cognitive consequences. This article presents the main characteristics and clinical effects of cocaine on the human organism, highlighting its role in the general impairment of health and the serious possible acute and chronic repercussions on the immature and vulnerable nervous system of adolescents.
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References
Castillo SM. Memory, decisions and emotions after the administration of cocaine: role of different neuroanatomical structures. Therapeia. 2019;7:71-83.
Bravo RR, Faria AC, Brito-da-Costa AM, Carmo H, Mladěnka P, Silva DD, et al. Cocaine: an updated overview on chemistry, detection, biokinetics, and pharmacotoxicological aspects including abuse pattern. Toxins (Basel). 2022;14:1-25. DOI: https://doi.org/10.3390/toxins14040278
Casey BJ, Cohen AO, Galvan A. The beautiful adolescent brains: an evolutionary developmental perspective. Ann NY Acad Sci. 2025;1546:58-74. DOI: https://doi.org/10.1111/nyas.15314
Frøyland LR, Pedersen W, Enstad F, von Soest T. School party culture as a driver of cocaine use among Norwegian adolescents: a cross-classified multilevel analysis. Drug Alcohol Dep. 2025;271:1-7. DOI: https://doi.org/10.1016/j.drugalcdep.2025.112627
Tokle R, Pedersen W. Cubs of Wall Street: cocaine use in top‐boy culture. British J Sociol. 2025;3:1-10. DOI: https://doi.org/10.1111/1468-4446.13212
Robet T, Santos-Cruz J, Zullino D, Semedo NC, Baldo B, Iuga R, et al. Clinical and public health challenges of crack consumption. Rev Med Suisse. 2025;21:226-30. DOI: https://doi.org/10.53738/REVMED.2025.21.904.226
Shau S, Zhou R. The relationship between drug addiction and adolescent cognitive development. Adv Soc Sci Educ Human Res. 2022;638:1-6. DOI: https://doi.org/10.2991/assehr.k.220110.218
Galván A. Adolescent brain development and contextual influences: a decade in review. J Res Adolesc. 2021;31:843-69. DOI: https://doi.org/10.1111/jora.12687
Salmanzadeh H, S. Ahmadi-Soleimani M, Pachenari N, Azadi M, Halliwell RF, Rubino T, Azizi H. Adolescent drug exposure: A review of evidence for the development of persistent changes in brain function. Brain Res Bull. 2020;156:105-17. DOI: https://doi.org/10.1016/j.brainresbull.2020.01.007
Ferschmann L, Bos MGN, Herting MM, Mills KL, Tamnes CK. Contextualizing adolescent structural brain development: environmental determinants and mental health outcomes. Cur Op Psychol. 2022;44:170-6. DOI: https://doi.org/10.1016/j.copsyc.2021.09.014
Green R, Wolf BJ, Chen A, Kirkland AE, Ferguson PL, Browning BD et al. Predictors of substance use initiation by early adolescence. Am J Psych. 2024;181:423-33. DOI: https://doi.org/10.1176/appi.ajp.20230882
Fuhrmann D, Knoll LJ, Blakemore S. Adolescence as a sensitive period of brain development. Trends Cogn. 2015;19:558-66. DOI: https://doi.org/10.1016/j.tics.2015.07.008
Baker AE, Galvan A, Fuligni AJ. The connecting brain in context: how adolescent plasticity supports learning and development. Dev Cogn Nuerosci. 2025;71:1-15. DOI: https://doi.org/10.1016/j.dcn.2024.101486
Braams BR, Krabbendam L. Adolescent development: from neurobiology to psychopathology. Cur Op Psychol. 2022;48:1-4. DOI: https://doi.org/10.1016/j.copsyc.2022.101490
Mirnics Z, Kovi Z, Tanyi Z, Grezsa F. Adolescent drug use, relational variables and personality factors. Psychiatr Danub. 2012;33:656-65.
Zeng X. Neuroplasticity and cocaine exposure during adolescence. Commun Human Res. 2024;40:211-8. DOI: https://doi.org/10.54254/2753-7064/40/20242331
Benowitz NL. Clinical pharmacology and toxicology of cocaine. Pharmacol Toxicol. 1993;72:3-12. DOI: https://doi.org/10.1111/j.1600-0773.1993.tb01331.x
Karch SB. Substance misuse: cocaine and other stimulants. Encycl Forensic Legal Med. 2016;4:363-70. DOI: https://doi.org/10.1016/B978-0-12-800034-2.00353-0
Kim ST, Park T. Acute and chronic effects of cocaine on cardiovascular health. Int J Mol Sci. 2019;20:584-605. DOI: https://doi.org/10.3390/ijms20030584
Ryan SA. Cocaine use in adolescents and young adults. Pediatr Clin N Am. 2019;66:1135-47. DOI: https://doi.org/10.1016/j.pcl.2019.08.014
Wang J, Deng X, Wu Y, Huang Y, Hou S, Zhang Y, Qiu T, Tong J, Chen X. Sub-lethal toxicity and elimination of the cocaine metabolite, benzoylecgonine: a narrative review. Ann Palliat Med. 2021;10:6936-47. DOI: https://doi.org/10.21037/apm-21-243
Steinfeld MR, Torregrossa MM. Consequences of adolescent drug use. Transl Psychiatr. 2023;13:1-22. DOI: https://doi.org/10.1038/s41398-023-02590-4
Beheshti I. Cocaine destroys gray matter brain cells and accelerates brain aging. Biology. 2023;12:1-14. DOI: https://doi.org/10.3390/biology12050752
Yang Z, Biswal BB, Klugah-Brown B, Ding G, Zhou W. Brain structural differences in cocaine use disorder: insights from multivariate and neurotransmitter analyses. Prog Neuropsychopharmacol Biol Psych. 2025;136:1-9. DOI: https://doi.org/10.1016/j.pnpbp.2024.111159
Schwartz EKC, Wolkowicz NR, Aquino JP, MacLean RR, Sofuoglu M. Cocaine use disorder (CUD): current clinical perspectives. Sub Abuse Rehab. 2022;13:25-46. DOI: https://doi.org/10.2147/SAR.S337338
Wang X. Brain structural consequences of chronic cocaine exposure and their effects on behavior. Biol Psych. 2021;89:11-2. DOI: https://doi.org/10.1016/j.biopsych.2020.12.002
Clare K, Park K, Pan Y, Lejuez CW, Volkow ND, Du C. Neurovascular effects of cocaine: relevance to addiction. Front Pharmacol. 2024;22:1-17. DOI: https://doi.org/10.3389/fphar.2024.1357422
Farooque U, Okorie N, Kataria S, Bollampally VC, Shah SF. Cocaine-induced headache: a review of pathogenesis, presentation, diagnosis, and management. Cureus. 2020;12:1-5. DOI: https://doi.org/10.7759/cureus.10128
Li K, Gu L, Cai H, Lu H, Mackie K, Guo F. Human brain organoids for understanding substance use disorders. Drug Metab Pharmacol. 2025;60:1-13. DOI: https://doi.org/10.1016/j.dmpk.2024.101036
Poireau M, Segobind S, Maillarda A, Clergue-Duvala V, Icicka R, Azuara J, et al. Brain alterations in Cocaine Use Disorder: does the route of use matter and does it relate to the treatment outcome. Psych Res: Neuroim. 2024;342:1-8. DOI: https://doi.org/10.1016/j.pscychresns.2024.111830
Melo CAA, Guimarães HRG, Medeiros RCF, Souza GCA, Santos PBD, Torrres ACSP. Oral changes in cocaine abusers: an integrative review. Br J Otorh. 2022;88:633-41. DOI: https://doi.org/10.1016/j.bjorl.2021.04.011
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