Use of probiotics in vaginal infections

Authors

  • Francisca Loaiza Castro Ministry of Public Health, Quito- Ecuador
  • Ricardo Carvajal Chancay School of Medicine, UNIR University, Quito- Ecuador
  • Anthony Rojas Toledo School of Medicine, UTPL University, Loja- Ecuador
  • Nataly Ontaneda Tello School of Medicine, UCE University, Quito- Ecuador
  • Jeordy Becerra Zavala School of Medicine, PUCE University, Quito- Ecuador
  • Cristina Pacheco Melo Department of Medicine, Armed Forces Hospital, Quito- Ecuador
  • Emily Dennise Moyano Department of Medicine, Armed Forces Hospital, Quito- Ecuador

DOI:

https://doi.org/10.18203/2320-6012.ijrms20252436

Keywords:

Multi-resistance, Probiotics, Vaginal infections, Vaginosis

Abstract

Vaginal infections are characterized by an overgrowth of microorganisms opportunistic and decreased levels of Lactobacillus. Vaginosis is common in women of childbearing age, perimenopausal women, women with polycystic ovary syndrome, pregnant women and adolescents. Vaginosis is often underestimated or misdiagnosed. Multiple studies mention that vaginosis detection tests should be performed on all high-risk pregnancies, women with significant obstetric history such as premature abortions and those who suffer from tuberculosis, because they are a risk factor for the development of abortions, premature rupture of membranes, choriomanionitis or preterm births. A challenge that is becoming more and more common revolves around the resistance of the microorganisms that cause vaginosis to the established treatments, generating recurrent and multi-resistant infections. For the treatment of different vaginosis, antibiotics and antifungals are prescribed. Studies point out the importance of prescribing antibiotics together with probiotics and thus avoiding dysbiosis in order to avoid recurrence of vaginal infections. Probiotics must be administered in the necessary dose and time so that they can generate a positive effect. More than 80% of Lactobacillus species must be present in a probiotic to ensure adequate acid and bactericidal production to prevent microfilm formation. The results of the use of probiotics will depend on the quality of the formula and the maintenance of the cold chain.

Metrics

Metrics Loading ...

References

Liu P, Lu Y, Li R, Chen X. Use of probiotic lactobacilli in the treatment of vaginal infections: In vitro and in vivo investigations. Front Cell Infect Microbiol. 2023;13:1153894. DOI: https://doi.org/10.3389/fcimb.2023.1153894

Wu LY, Yang TH, Ou YC, Lin H. The role of probiotics in women's health: An update narrative review. Taiwan J Obstet Gynecol. 2024;63:29-36. DOI: https://doi.org/10.1016/j.tjog.2023.09.018

Gaziano R, Sabbatini S, Roselletti E, Perito S, Monari C. Saccharomyces cerevisiae-Based Probiotics as Novel Antimicrobial Agents to Prevent and Treat Vaginal Infections. Front Microbiol. 2020;11:718. DOI: https://doi.org/10.3389/fmicb.2020.00718

Mashatan N, Heidari R, Altafi M, Amiri A, Ommati MM, Hashemzaei M. Probiotics in vaginal health. Pathog Dis. 2023;81. DOI: https://doi.org/10.1093/femspd/ftad012

Han Y, Ren QL. Does probiotics work for bacterial vaginosis and vulvovaginal candidiasis. Curr Opin Pharmacol. 2021;61:83-90. DOI: https://doi.org/10.1016/j.coph.2021.09.004

Tachedjian G, Aldunate M, Bradshaw CS, Cone RA. The role of lactic acid production by probiotic Lactobacillus species in vaginal health. Res Microbiol. 2017;168(9–10):782–92. DOI: https://doi.org/10.1016/j.resmic.2017.04.001

Chee WJY, Chew SY, Than LTL. Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact. 2020;19(1):203.

Mizgier M, Jarzabek-Bielecka G, Mruczyk K, Kedzia W. The role of diet and probiotics in prevention and treatment of bacterial vaginosis and vulvovaginal candidiasis in adolescent girls and non-pregnant women. Ginekol Pol. 2020;91(7):412–6. DOI: https://doi.org/10.5603/GP.2020.0070

Gupta V, Mastromarino P, Garg R. Effectiveness of prophylactic oral and/or vaginal probiotic supplementation in the prevention of recurrent urinary tract infections: A randomized, double-blind, placebo-controlled trial. Clin Infect Dis. 2024;78(5):1154–61. DOI: https://doi.org/10.1093/cid/ciad766

Vazquez F, Fernández-Blázquez A, García B. Vaginosis. Microbiota vaginal. Enferm Infecc Microbiol Clin. 2019;37(9):592–601. DOI: https://doi.org/10.1016/j.eimc.2018.11.009

Chee WJY, Chew SY, Than LTL. Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health. Microb Cell Fact. 2020;19(1):203. DOI: https://doi.org/10.1186/s12934-020-01464-4

De Seta F, Campisciano G, Zanotta N, Ricci G, Comar M. The vaginal community state types microbiome-immune network as key factor for bacterial vaginosis and aerobic vaginitis. Front Microbiol. 2019;10:2451. DOI: https://doi.org/10.3389/fmicb.2019.02451

Kalia N, Singh J, Kaur M. Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review. Ann Clin Microbiol Antimicrob. 2020;19(1):5. DOI: https://doi.org/10.1186/s12941-020-0347-4

O’Hanlon DE, Come RA, Moench TR. Vaginal pH measured in vivo: lactobacilli determine pH and lactic acid concentration. BMC Microbiol. 2019;19(1):67. DOI: https://doi.org/10.1186/s12866-019-1388-8

Zalambani C, Rizzardi N, Marziali G, Foschi C, Morselli S, Djusse ME, et al. Role of D (−)-Lactic Acid in Prevention of Chlamydia trachomatis Infection in an In Vitro Model of HeLa Cells. Pathogens. 2023;12(7):883. DOI: https://doi.org/10.3390/pathogens12070883

Lee CY, Diegel J, France MT, Ravel J, Arnold KB. Evaluation of vaginal microbiome equilibrium states identifies microbial parameters linked to resilience after menses and antibiotic therapy. PLOS Comp Biol. 2023;19(8):1011295. DOI: https://doi.org/10.1371/journal.pcbi.1011295

Atassi F, Pho Viet Ahn DL, Lievin-Le Moal V. Diverse expression of antimicrobial activities against bacterial vaginosis and urinary tract infection pathogens by cervicovaginal microbiota strains of Lactobacillus gasseri and Lactobacillus crispatus. Front Microbiol. 2019;10:2900. DOI: https://doi.org/10.3389/fmicb.2019.02900

Zheng N, Guo R, Wang J, Zhou W, Ling Z. Contribution of Lactobacillus iners to vaginal health and diseases: a systematic review. Front Inf Microbiol. 2021;11:792787. DOI: https://doi.org/10.3389/fcimb.2021.792787

Aldunate M, Srbinovski D, Hearps AC, Latham CF, Ramsland PA, Gugasyan R, et al. Antimicrobial and immune modulatory effects of lactic acid and short chain fatty acids produced by vaginal microbiota associated with eubiosis and bacterial vaginosis. Front Physiol. 2015;6:164. DOI: https://doi.org/10.3389/fphys.2015.00164

Stoyancheva G, Marzotto M, Dellaglio F, Torriani S. Bacteriocin production and gene sequencing analysis from vaginal Lactobacillus strains. Arch Microbiol. 2014;196(9):645–53. DOI: https://doi.org/10.1007/s00203-014-1003-1

Downloads

Published

2025-07-30

How to Cite

Castro, F. L., Chancay, R. C., Toledo, A. R., Tello, N. O., Zavala, J. B., Melo, C. P., & Moyano, E. D. (2025). Use of probiotics in vaginal infections. International Journal of Research in Medical Sciences, 13(8), 3537–3543. https://doi.org/10.18203/2320-6012.ijrms20252436

Issue

Section

Review Articles