Juvenile post dengue mucormycosis-reporting a rare entity with review of literature

Authors

  • Kavita N. Garg Department of Oral Pathology and Microbiology, Chandra Dental College and Hospital, Barabanki, Uttar Pradesh, India
  • Vineet Raj Dr. Raj Dental Care, Lucknow, Uttar Pradesh, India
  • Sujeet Singh Department of Oral & Maxillofacial Surgery, Chandra Dental College and Hospital, Barabanki, Uttar Pradesh, India
  • Ruby Dwivedi Department of Dentistry, Autonomous State Medical College, Kanpur Dehat, Uttar Pradesh, India
  • Praveen K. Pandey Department of Oral & Maxillofacial Surgery, Chandra Dental College and Hospital, Barabanki, Uttar Pradesh, India
  • Amit Thahriani Department of Oral Pathology and Microbiology, Chandra Dental College and Hospital, Barabanki, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20252052

Keywords:

Mucormycosis, Fungal infection, Dengue, Opportunistic infection

Abstract

Invasive mucormycosis is a life-threatening fungal infection that most frequently occurs in patients with underlying comorbidities that impacts immune system function. It is an opportunistic and frequently fulminant fungal infection caused by a saprophytic organism belonging to class zygomycetes. These organisms are omnipresent and grow in their natural state on the variety of decaying organic materials. These organisms are present in the nasal passages and oral cavities of normal individuals. Here, we report a rare case of juvenile post dengue mucormycosis along with brief insight into the review of literature. Histopathological examination of the necrotic bone and overlying tissue was done in OPD in a juvenile patient who reported with purulent discharge and having a history of dengue. There were abundant PAS positive fungal hyphae. This case report will acquaint the oral care providers of a possible association of mucormycosis and dengue and highlight the importance of early diagnosis to optimize the treatment outcomes and prognosis in such cases. Mucormycosis is a rare opportunistic infection that spreads promptly and is life-threatening. Therefore, early diagnosis and prompt treatment is required to reduce the mortality and morbidity of this lethal infection.

Metrics

Metrics Loading ...

References

Neville WB, Damm D, Allen CM, Bouquot JE. Text Book of Oral & Maxillofacial Pathology. 2nd edition. Philadelphia: W.B. Saunders. 2001;16.

Shafer, Hine, Levy, Sivapathasundharam B, Rajendran R. Textbook of oral pathology. 5th edition. Elsevier Publisher Private Limited India. 2006;510.

Lazar SP, Lukaszewicz JM, Persad KA, Reinhardt JF. Rhinocerebral Mucor circinelloides infection in immune-compromised patient following yogurt ingestion. Del Med J. 2014;86(8):245-8.

Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in Human Disease. Clin Microbiol Rev. 2000;13(2):236-301. DOI: https://doi.org/10.1128/CMR.13.2.236

Pyrgos V, Shoham S, Walsh TJ. Pulmonary zygomycosis. Semin Respir Crit Care Med. 2008;29:111-20. DOI: https://doi.org/10.1055/s-2008-1063850

Mignogna MD, Fortuna G, Leuci S, Adamo D, Ruoppo E, Siano M, et al. Mucormycosis in immunocompetent patients: a case-series of patients with maxillary sinus involvement and a critical review of the literature. Int J Infect Dis. 2011;15(8):e533-40. DOI: https://doi.org/10.1016/j.ijid.2011.02.005

Pillalamarri M, Pasupuleti S, Manyam R, Moturi K, Tatapud R. Mucormycosis in a Typhoid Treated Patient: A Case Report with Review of Literature. Oral Maxillofac Pathol J. 2023;14(1):138-41.

Afroze S N, Korlepara R , G V Rao, Madala J. Mucormycosis in a diabetic patient. Contemp Clin Dent, 2017;8(4):662-6. DOI: https://doi.org/10.4103/ccd.ccd_558_17

Kwon-Chung KJ. Taxonomy of fungi causing mucormycosis and entomophthoramycosis (zygomycosis) and nomenclature of the disease: molecular mycologic perspectives. Clin Infect Dis. 2012;54(1):S8-S15. DOI: https://doi.org/10.1093/cid/cir864

Paltauf A. Mycosis mucorina: Ein Beitrag zur Kenntnis der menschilchen Fadenpiltzer-krankungen. Virchows Arch Pathol Anat. 1885;102:543-64. DOI: https://doi.org/10.1515/9783112390382-025

Baker RD. Mucormycosis; a new disease? J Am Med Assoc. 1957;163(10):805-8. DOI: https://doi.org/10.1001/jama.1957.02970450007003

Spellberg B, Edwards J, Ibrahim A. Novel perspectives on mucormycosis: Pathophysiology, presentation, and management. Clin Microbiol Rev. 2005;18(3):556-69. DOI: https://doi.org/10.1128/CMR.18.3.556-569.2005

Walther G, Wagner L, Kurzai O. Updates on the Taxonomy of Mucorales with an Emphasis on Clinically Important Taxa. J Fungi (Basel). 2019;5(4):1-9. DOI: https://doi.org/10.3390/jof5040106

Orlowski M. Mucor dimorphism. Microbiol Rev. 1991;55(2):234-58. DOI: https://doi.org/10.1128/mr.55.2.234-258.1991

Challa S. Mucormycosis: Pathogenesis and Pathology. Curr Fungal Infect Rep. 2019;13(1):11-20. DOI: https://doi.org/10.1007/s12281-019-0337-1

Kajs‑Wyllie M. Hyperbaric oxygen therapy for rhinocerebral fungal infection. J Neurosci Nurs 1995;27:174‑81. DOI: https://doi.org/10.1097/01376517-199506000-00006

Kalaskar RR, Kalaskar AR, Ganvir S. Oral mucormycosis in an 18-month-old child: a rare case report with a literature review. J Korean Assoc Oral Maxillofac Surg. 2016;42(2):105-10. DOI: https://doi.org/10.5125/jkaoms.2016.42.2.105

Buhl MR, Joseph TP, Snelling BE, Buhl L. Temporofacialzygomycosis in a pregnant woman. Infection. 1992;20:230-2. DOI: https://doi.org/10.1007/BF02033066

Ambereen A, Rahman S A, Rehman S, Zaidi K, Arif HS. Mandibular mucormycosis following SARS-CoV-2 infection – A case report and review of literature. Clin Infect Pract. 2021;12:1-6. DOI: https://doi.org/10.1016/j.clinpr.2021.100099

Steinbrink MJ, Miceli HM. Clinical Review of Mucormycosis. Infect Dis Clin North Am. 2021;35(2):435-52. DOI: https://doi.org/10.1016/j.idc.2021.03.009

Toppo NA, Thakur A, Tiwari S. A rare case study to understand the path of post dengue mucormycosis. Indian J Public Health Res Dev. 2023;14;1:209-12. DOI: https://doi.org/10.37506/ijphrd.v14i1.18838

Halstead SB. Dengue. Lancet. 2007;370:1644-52. DOI: https://doi.org/10.1016/S0140-6736(07)61687-0

Suganya R, Malathi N, Karthikeyan V, Janagaraj DV. Mucormycosis a brief review. J Pure Appl Microbiol. 2019;13(1):161-5. DOI: https://doi.org/10.22207/JPAM.13.1.16

Downloads

Published

2025-06-27

How to Cite

Garg, K. N., Raj, V., Singh, S., Dwivedi, R., Pandey, P. K., & Thahriani, A. (2025). Juvenile post dengue mucormycosis-reporting a rare entity with review of literature. International Journal of Research in Medical Sciences, 13(7), 3066–3071. https://doi.org/10.18203/2320-6012.ijrms20252052

Issue

Section

Case Reports