Primary testicular diffuse large B-cell lymphoma (germinal centre B-cell type) masquerading as spermatocytic seminoma: a morphological conundrum

Amit K. Verma; Siddharth Lilha; Geeta Yadav; Preeti Agarwal; Avneet Gupta

doi:10.18203/2320-6012.ijrms20252063

Authors

Amit K. Verma Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India
Siddharth Lilha Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India
Geeta Yadav Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India
Preeti Agarwal Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India
Avneet Gupta Department of Urology, KGMU, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20252063

Keywords:

B-cell lymphoma, lymphoid cells, Spermatocytic seminoma

Abstract

Diffuse large B cell lymphoma is usually known for proliferation for medium to large abnormal lymphoid cells. Intermixed polymorphous cells may be seen in occasional cases. This type of morphology when seen in testicular lymphoma in an adult male may be misinterpreted as spermatocytic seminoma as seen in the reported case of a 48-year-old male with slow growing testicular mass. Immunohistochemistry is a must to confirm diagnosis and hence impart correct treatment in these type of cases. Spermatocytic seminoma is CD117, SALL 4 positive whereas DLBCL will display LCA, CD20, CD10, and/or bcl-6, MUM1 expression.

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Author Biographies

Amit K. Verma, Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India

Junior Resident, Department of Pathology

Siddharth Lilha, Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India

Dr. Siddharth Lilha , Junior Resident, Department of Pathology,

Geeta Yadav, Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India

Additional Professor, Department of Pathology,

Avneet Gupta, Department of Urology, KGMU, Lucknow, Uttar Pradesh, India

Assistant Professor, Department of Urology,

References

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Cheah CY, Wirth A, Seymour JF. Primary testicular lymphoma. Blood. 2014;123(4):486-93. DOI: https://doi.org/10.1182/blood-2013-10-530659