Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis

Authors

  • Mohan Lal Gupta Department of Pathology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India
  • Kaustubh Singh Department of Pathology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20163644

Keywords:

FNAC, Lymphadenopathy, Metastatic carcinoma, Tubercular lymphadenitis

Abstract

Background: Lymphadenopathy is very common presenting symptoms. Fine needle aspiration cytology (FNAC) is used to evaluate the nature of the lesion. Etiology of lymphadenopathy in head and neck region vary from benign reactive hyperplasia to tubercular granulomatous lesion to malignancy. The aim of present study was to evaluate the sensitivity, specificity and predictive value in tuberculosis and metastatic carcinoma.

Methods: A total of 80 patients out of 200 patients who underwent FNAC were evaluated by histopathological examination for correlation. Aspiration smears and histopathological slides were evaluated and results were calculated for sensitivity, specificity and predictive value.

Results: Reactive lymphadenitis was seen in 40 patients followed by tubercular granulomatous lymphadenitis in 20 patients and malignant lesions in 20 patients. Histology revealed 18 patients of tubercular lymphadenitis, 43 of reactive changes, 12 of metastasis in lymph nodes and 7 of lymphomas. Correlating the findings, we could achieve 100% sensitivity and 96.7% specificity for tubercular lymphadenopathy and for metastatic it was 98.5% and 100% respectively.

Conclusions: We have found FNAC a satisfactory tool in the diagnosis of tubercular and malignant lymphadenopathy. FNAC used in conjunction with clinical findings, radiological and laboratory investigations can be a cost effective method for the diagnosis of lymphadenopathy.

References

Frable WJ, Frable MA. Fine Needle Aspiration Biopsy revisited. Laryngoscope. 1982;92(2):1414.

Buley ID. Fine needle aspiration of lymph nodes. J clin patho. 1998;51:881-5.

Orell SR, Sterer GF, Whitaker D. Fine needle aspiration cytology, 4th edition, Chirchill Livingston. 2005;1-8,83-124.

Malakar D, Jajoo ILN, Swarup K,Gupta OP, Jain AK, Poflee VW. A clinical evaluation of Fine needle aspiration cytology in the diagnosis of lymphadenopathy. Ind. J. Tub. 1991;38:17.

Lioe TF, Elliott H, Allen DC, Spence RA. The role of fine needle aspiration cytology (FNAC) in the investigation of superficial lymphadenopathy; uses and limitations of the technique. Cytopathol. 1998;10(5):291-7.

Klemi PJ, Elo JJ, Joensuu H. Fine needle aspiration biopsy in granulomatous disorders. Sarcoidosis. 1987;4(1):38-41.

Blackshaw A. Metastatic tumour in lymph nodes. In: Standfield AG, D’Ardenne, editors. Lymph node biopsy interpretation. London: Churchill Livingstone, 1987: 380-397.

Coyne JD, Banerjee SS, Menasche LP, Mene A. Granulomatous lymphadenitis associated with metastatic malignant melanoma. Histopathol. 1996;28(5):470-2.

Santini D, Pasquinelli G, Alberghini M, Martinelli GN, Taffurelli M. Invasive breast carcinoma with granulomatous response and deposition of unusual amyloid. J Clin Pathol. 1992;45(10):885-8.

Khurana KK, Stanley MW, Powers CN, Pitman MB. Aspiration cytology of malignant neoplasms associated with granulomas and granuloma-like features: diagnostic dilemmas. Cancer. 1998;84(2):84-91.

Gregori HB, Othersen HB, Moore MP. The significance of sarcoid-like lesions in association with malignant neoplasm. Am J Surg. 1962;104:577-86.

Oberman H. Invasive carcinoma of the breast with granulomatous response. Am J Clin Pathol. 1987;88(6):718-21.

Kataria P, Sachdeva M, Singh NK. FNAC as a diagnostic tool for the diagnosis of cervical lymphadenopathy. Bull Environ Pharmacol Life Sci. 2012;1:72‑5.

Tilak V, Dhadel AV, Jain R. Fine needle aspiration cytology of the head and neck masses. Indian J Pathol Microbiol. 2002;45:23‑9.

Lefebvre JL, Coche‑Dequeant B, Van JT, Buisset E, Adenis A. Cervical lymph nodes from an unknown primary tumor in 190 patients. Am J Surg. 1990;160:443‑6.

Janot F, Klijanienko J, Russo A, Mamet JP, de Braud F, El‑Naggar AK, et al. Prognostic value of clinicopathologic parameters in head and neck squamous cell carcinoma: A prospective analysis. Br J Cancer. 1996;73:531‑8.

Gupta RK, Naran S, Lallu S, Fauck R. The diagnostic value of fine needle aspiration cytology (FNCA) in the assessment of palpable supraclavicular lymph nodes: A study of 218 cases. Cytopathology. 2003;14:201‑7.

Morris‑Stiff G, Cheang P, Key S, Verghese A, Havard TJ. Does the surgeon still have a role to play in the diagnosis and management of lymphomas? World J Surg Oncol. 2008;6:13.

Dong HY, Harris NL, Preffer FI, Pitman BP. Fine needle aspiration biopsy in the diagnosis and classification of primary and recurrent lymphoma: A retrospective analysis of the utility of cytomorphology and flow cytometry. Mod Pathol. 2001;14:472‑81.

Rajwanshi A, Bhambani S, Das DK. Fine Needle Aspiration Cytology in the diagnosis of Tuberculosis; Diagn. Cytopathol. 1987;3(1):13.

Engzell U, Jakobbsen PA, Zajicek J. Aspiration biopsy of metastatic carcinoma in lymphnodes of the neck A review of 1101 consecutive cases; Act. Otolaryng. 1972;72:138.

Ross JE, Scanlon EF, Christ MA. Aspiration cytology of Head and Neck masses; Am. J. Surg; 1978;136:342.

Gupta SK, Dutta JK, Aikat M, Gupta BD. Evaluation of Fine needle biopsy technique in diagnosis of tumours. Ind. J. Can. 1975;12:257.

Downloads

Published

2016-12-19

How to Cite

Gupta, M. L., & Singh, K. (2016). Correlation of fine needle aspiration cytology lymph node with histopathological diagnosis. International Journal of Research in Medical Sciences, 4(11), 4719–4723. https://doi.org/10.18203/2320-6012.ijrms20163644

Issue

Section

Original Research Articles