A study of surgical pathology of thyroid lesions
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252782Keywords:
Thyroid lesions, Non-neoplastic, NeoplasticAbstract
Background: Thyroid lesions commonly present as midline neck swelling that move with deglutition. These lesions are broadly divided into non-neoplastic and neoplastic. Non-neoplastic can be developmental, inflammatory, hyperplastic. Neoplastic are stratified into benign tumors, low risk neoplasms and malignant neoplasms. Most of these lesions are amenable to surgical resection. This study aims to analyse the demographic features and histopathological spectrum of surgically resected thyroid lesions.
Methods: A total of 55 surgically resected thyroid specimens received in Department of Pathology, World College of Medical Sciences and Research Hospital were included. Demographic and clinical details were obtained from departmental records. Histopathological examination was conducted according to standard protocol. Percentages and simple frequency tables were used for analysis.
Results: Age ranged from 20-97 years. Maximum number of cases were reported in 3rd to 5th decade. Female: male ratio was 5.1:1. Non-neoplastic lesions were 29 (52.72%) and 26 (47.27%) neoplastic lesions were encountered in which colloid goitre and papillary carcinoma thyroid were the commonest ones respectively.
Conclusions: Non-neoplastic lesions were slightly more common than neoplastic lesions. Ultrasonography (USG), thyroid function test and fine needle aspiration cytology (FNAC) give a clue but study of histomorphologic features is the final confirmatory test guiding a clinician towards further patient management.
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References
Beigh A, Amin J, Junaid S, Wani LA, Farooq S, Farooq S. Histopathological study of thyroid neoplastic lesions in a tertiary care hospital - a 5 year study. Int J Contemp Med Res. 2018;5(4):D4-7.
Sreedevi A, Sheela K. Histopathological spectrum of non-neoplastic and neoplastic lesions of thyroid-2 year study in a tertiary care teaching hospital. J Med Sci Clin Res. 2018;6:514-9.
Yeung MJ, Serpell JW. Management of the solitary thyroid nodule. Oncologist. 2008;13(2):105-12. DOI: https://doi.org/10.1634/theoncologist.2007-0212
Bamanikar S, Bamanikar A, Jadhav S, Jadhav P, Kumar H, Soraisham P. Cyto-histology and clinical correlation of thyroid gland lesions: A 3 year study in a tertiary hospital. Clin Cancer Investig J. 2014;3:208-12. DOI: https://doi.org/10.4103/2278-0513.132112
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016;26(1):1-133. DOI: https://doi.org/10.1089/thy.2015.0020
Welker MJ, Orlov D. Thyroid nodules. Am Fam Physician. 2003;67(3):559-66.
Vanderpump MP, Tunbridge WM, French JM, Appleton D, Bates D, Clark F, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf). 1995;43(1):55-68. DOI: https://doi.org/10.1111/j.1365-2265.1995.tb01894.x
Belfiore A, La Rosa GL, La Porta GA, Giuffrida D, Milazzo G, Lupo L, et al. Cancer risk in patients with cold thyroid nodules: relevance of iodine intake, sex, age, and multinodularity. Am J Med. 1992;93(4):363-9. DOI: https://doi.org/10.1016/0002-9343(92)90164-7
Durante C, Cost ante G, Lucisano G, Bruno R, Meringolo D, Paciaroni A, et al. The natural history of benign thyroid nodules. JAMA. 2015;313(9):926-35. DOI: https://doi.org/10.1001/jama.2015.0956
Popoveniuc G, Jonklaas J. Thyroid nodules. Med Clin North Am. 2012;96(2):329-49. DOI: https://doi.org/10.1016/j.mcna.2012.02.002
Goyal D, Negi SR, Sajid A, Ahuja P. Histopathological Spectrum of Thyroid lesions at Tertiary care Hospital in Western Rajasthan. Asian J Pharm Clin Res. 2023;16(10):186-90. DOI: https://doi.org/10.22159/ajpcr.2023.v16i10.47848
Ijomone EA, Duduyemi BM, Udoye E, Nwosu SO. Histopathological review of thyroid diseases in southern Nigeria-a ten year retrospective study. J Med Med Sci. 2014;5:127-32.
Prabha V, Bhuvaneswari MG. A Study of Histopathological Spectrum of Thyroid Lesions: An Observational Study. Int J Sci Stud. 2019;7(1):1-4.
Turkey HA, Mahadani J. Analysis of histopathological pattern of thyroid lesions in a tertiary care hospital. IP Arch Cytol Histopathology Res. 2022;7(1):42-6. DOI: https://doi.org/10.18231/j.achr.2022.008
Ramesh VL, Shwetha R. Study of distribution of the thyroid lesions in a hospital. Int J Sci Res. 2014;3(21):2441-3.
Jagadale K, Srivastava H, Nimburgi R. Recent trends in distribution of thyroid lesions in a tertiary care hospital in India. Eur J Biomed Pharm Sci. 2016;3(4):234-9.
Padmom L, Beena D, Sapru K. Histopathological spectrum of thyroid lesions- a two years study. J Evol Med Dent Sci. 2020;9(07):418-21. DOI: https://doi.org/10.14260/jemds/2020/95
Gupta A, Jaipal D, Kulhari S, Gupta N. Histopathological study of thyroid lesions and correlation with ultrasonography and thyroid profile in western zone of Rajasthan, India. Int J Res Med Sci. 2016;4:1204-8. DOI: https://doi.org/10.18203/2320-6012.ijrms20160810
Shalini RS, Sudha I. Histopathological spectrum of thyroid gland lesions in a tertiary care center- a five year retrospective study. IOSR J Dent Med Sci. 2019;18(2):70-3.
Nzegwu MA, Njeze GE, Olusina DB, Ogochukwu AI. A histological update of thyroid lesions in Enugu, Nigeria: a 5 year retrospective study. Asian J Exp Biol Sci. 2010;1(2):1-5.
Abdulkareem FB, Banjo AA, Elesha SO. Histological review of thyroid lesions: a 13 year retrospective study (1989 2001). Niger Postgrad Med J. 2005;12(3):210-4. DOI: https://doi.org/10.4103/1117-1936.175287
Ghartimagar D, Ghosh A, Shrestha MK, Thapa S, Talwar OP. Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2020;58(231):856-61. DOI: https://doi.org/10.31729/jnma.5038
Office of Dietary Supplements. Iodine. 2018. Available at: https://www.ods.od.nih.gov/factsheets/ Iodine-Health Professional. Accessed on 10 May 2025.
Adenji KA, Anjorin AS, Ojunsulire A. Histopathological patterns of thyroid diseases in a Nigerian population. Niger Q J Hosp Med. 1998;8:241-4.
Ramzi SC, Vinay K, Nelson F. Robbins and Cotran Pathologic basis of disease. St. Louis: Elsevier Saunders. 2005;11-7.
Albasri A, Hussainy AS, Alhujaily A, Sawaf Z. Histopathological patterns of thyroid disease in Al-Madinah region of Saudi Arabia. Asian Pac J Cancer Prev. 2014;15(14):5565-70.
Beigh A, Amin J, Junaid S, Wani LA, Farooq S, Farooq S. Histopathological study of thyroid neoplastic lesions in a tertiary care hospital-a 5 year study. Int J Contemp Med Res. 2018;5(4):D4-7. DOI: https://doi.org/10.21276/ijcmr.2018.5.4.10
Padmavathi M, Raj JA. Histopathological spectrum of non-neoplastic and neoplastic lesions of thyroid: A 5-year prospective study in a tertiary care hospital. Int J Med Sci. 2017;3:63-8. DOI: https://doi.org/10.5005/jp-journals-10045-0059
Lloyd RV, Osamura RY, Klöppel G, Rosai J. Who Classification of Endocrine Organs. 4th edition. Lyon, France: IARC. 2017. Available at: https://www.iarc. who.int/news-events/who-classification-of tumours-of-endocrine-organs. Accessed on 10 May 2025.
Albasri A, Hussainy AS, Alhujaily A, Sawaf Z. Histopathological patterns of thyroid disease in Al-Madinah region of Saudi Arabia. Asian Pac J Cancer Prev. 2014;15(14):5565-70. DOI: https://doi.org/10.7314/APJCP.2014.15.14.5565
Singh SR, Iyengar S. Histopathological Spectrum of Thyroid Gland Lesions in A Tertiary Care Center- A Five Year Retrospective Study. J Dent Med Sci. 2019;18(2):70-3.
Sreedevi AR, Sheela KM. Histopathological Spectrum of Non Neoplastic and Neoplastic Lesions of Thyroid-2 Year Study in a Tertiary Care Teaching Hospital. J Med Sci Clin Res. 2018;6(6):514-9. DOI: https://doi.org/10.18535/jmscr/v6i6.86
Limaiem F, Rehman A, Mazzoni T. Papillary Thyroid Carcinoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2025.
Lee JS, Lee JS, Yun HJ, Kim SM, Chang H, Lee YS, et al. Aggressive Subtypes of Papillary Thyroid Carcinoma Smaller Than 1 cm. J Clin Endocrinol Metab. 2023;108(6):1370-5. DOI: https://doi.org/10.1210/clinem/dgac739
Rahmat F, Kumar Marutha Muthu A, S Raja Gopal N, Jo Han S, Yahaya AS. Papillary Thyroid Carcinoma as a Lateral Neck Cyst: A Cystic Metastatic Node versus an Ectopic Thyroid Tissue. Case Rep Endocrinol. 2018;2018:5198297. DOI: https://doi.org/10.1155/2018/5198297