Syringomatous tumor of the nipple: master of deceit
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252808Keywords:
Syringomatous tumor of the nipple, Breast carcinoma, Syringomatous adenomaAbstract
Syringomatous tumor (SyT) of the nipple is a locally infiltrative, benign neoplasm known to rarely involve breast. It usually presents as a unilateral retroareolar mass and may be associated with pain, nipple discharge or inversion. Microscopically tubules and ducts with comma-like configuration lined by double layered epithelium along with keratinizing cysts are seen similar to cutaneous adnexal neoplasm of eccrine origin. Since it shows infiltration into smooth muscle and nerves on microscopy, it is prone to be misdiagnosed as invasive carcinoma of breast. Initial management of SyT of the nipple requires complete resection of the lump with negative histological margins as this tumor is known to reoccur if incompletely excised. So, awareness of this entity is helpful when dealing with retroareolar breast lump clinically, radiologically and histologically. We present a case of SyT reported on a Tru-cut biopsy specimen in a 40 year old female presenting with retroareolar lump, for being a rare entity in breast and a diagnostic dilemma.
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References
Rosen PP. Syringomatous adenoma of the nipple. Am J Surg Pathol. 1983;7(8):739-45. DOI: https://doi.org/10.1097/00000478-198312000-00003
Rosen PP. Papilloma and Related Benign Tumors. Rosen's Breast Pathology. 3rd ed. Philadelphia: Lippincott Williams and Wilkins. 2009;125-30.
Carter E, Dyess DL. Infiltrating syringomatous adenoma of the nipple: a case report and 20-year retrospective review. Breast J. 2004;10(5):443-7. DOI: https://doi.org/10.1111/j.1075-122X.2004.21518.x
Montgomery ND, Bianchi GD, Klauber-Demore N, Budwit DA. Bilateral Syringomatous Adenomas of the Nipple: Case Report With Immunohistochemical Characterization of a Rare Tumor Mimicking
Malignancy. Am J Clin Pathol. 2014;141(5):727-31.
Paramaguru R, Ramkumar S. Syringomatous adenoma of the nipple in a male breast: a case report with a brief review of literature and histomorphological approach to diagnosis. Cureus. 2021;13(11):e19586 DOI: https://doi.org/10.7759/cureus.19586
Page RN, Dittrich L, King R, Boulos F, Page DL. Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report. J Cutan Pathol. 2009;36(11):1206-9. DOI: https://doi.org/10.1111/j.1600-0560.2009.01267.x
Öwall L, Mygind H, Rosenborg Å, Lænkholm AV. Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple. Case Rep Pathol. 2019;2019:9461815. DOI: https://doi.org/10.1155/2019/9461815
Oo KZ, Xiao PQ. Infiltrating syringomatous adenoma of the nipple. Clinical presentation and literature review. Arch Pathol Lab Med. 2009;133:1487-9. DOI: https://doi.org/10.5858/133.9.1487
Barbareschi M, Pecciarini L, Cangi MG. p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast. Am J Surg Pathol. 2001;25(8):1054-60. DOI: https://doi.org/10.1097/00000478-200108000-00010
Dalal YD, Trivedi AK, Panchal V, Patel Y, Dalal DD. Nipple Adenoma: Case Report of a Rare Entity. Cureus. 2022;14(3):e22996. DOI: https://doi.org/10.7759/cureus.22996
Ishikawa S, Sako H, Masuda K, Tanaka T, Akioka K, Yamamoto Y, et al. Syringomatous adenoma of the nipple: a case report. J Med Case Rep. 2015;9:256. DOI: https://doi.org/10.1186/s13256-015-0739-9
Rosen PP, Ernsberger D. Low-grade adenosquamous carcinoma: a variant of metaplastic mammary carcinoma. Am J Surg Pathol. 1987;11:351-8. DOI: https://doi.org/10.1097/00000478-198705000-00003
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