Extracorporeal shockwave therapy for tendinopathies: a comprehensive literature review
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252447Keywords:
Extracorporeal shockwave therapy, Tendinopathy, Pain modulation, Randomized controlled trials, PhysiotherapyAbstract
Tendinopathies, including Achilles, patellar, lateral epicondylitis, and plantar fasciitis, are chronic musculoskeletal disorders with limited responsiveness to conventional therapies. Extracorporeal shockwave therapy (ESWT), a non-invasive intervention, has emerged as a promising modality targeting both symptomatic relief and structural regeneration. To synthesize high-level evidence on the efficacy and mechanisms of ESWT in managing tendinopathies, emphasizing randomized controlled trials (RCTs), treatment protocols, patient outcomes, and methodological quality. Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a comprehensive search of four databases was conducted for English-language RCTs published between 2000 to 2024. Inclusion criteria focused on ESWT interventions for tendinopathies with reported clinical outcomes. Quality was assessed using the PEDro scale and Cochrane Risk of Bias 2.0 tool. Four RCTs involving 432 participants were included, addressing plantar fasciitis, Achilles tendinopathy, lateral epicondylitis, and patellar tendinopathy. ESWT demonstrated significant reductions in pain (VAS), improved functional scores (VISA-A, RM, AOFAS), and structural recovery. Focused ESWT showed deeper penetration and neovascularization benefits, while radial ESWT was more effective for superficial lesions. Variability in energy flux densities and session protocols influenced therapeutic response. PEDro scores ranged from 6 to 9, with low-to-moderate risk of bias. ESWT offers effective, non-invasive treatment for various tendinopathies, especially when conventional options fall short. Future research should emphasize protocol standardization, long-term outcome evaluation, and comparative efficacy with other regenerative modalities.
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References
Griffin C, Daniells K, Hill C, Franklyn-Miller A, Morin J B. A criteria-based rehabilitation program for chronic mid-portion Achilles tendinopathy: study protocol for a randomized controlled trial. BMC Musculoskeletal Disord. 2021;22:695. DOI: https://doi.org/10.1186/s12891-021-04553-6
Malliaras P, Barton CJ, Reeves ND, Langberg H. Achilles and patellar tendinopathy loading programmes. Sports Med. 2013;43:267-86. DOI: https://doi.org/10.1007/s40279-013-0019-z
Andres BM, Murrell GA. Treatment of tendinopathy: what works, what does not, and what is on the horizon. Clin Orthop Relat Res. 2008;466(7):1539-54. DOI: https://doi.org/10.1007/s11999-008-0260-1
Simplicio CL, Purita J, Murrell W, Santos GS, Dos Santos RG, Lana JFSD. Extracorporeal shock wave therapy mechanisms in musculoskeletal regenerative medicine. J Clin Orthop Trauma. 2020;11(S3):S309-18. DOI: https://doi.org/10.1016/j.jcot.2020.02.004
Vahdatpour B, Sajadieh S, Bateni V, Karami M, Sajjadieh H. Extracorporeal shock wave therapy in patients with plantar fasciitis. A randomized, placebo-controlled trial with ultrasonographic and subjective outcome assessments. J Res Med Sci. 2012;17(9):834-8.
Sun J, Gao F, Wang Y, Sun W, Jiang B, Li Z. Extracorporeal shock wave therapy is effective in treating chronic plantar fasciitis: A meta-analysis of RCTs. Medicine (Baltimore). 2017;96(15):e6621. DOI: https://doi.org/10.1097/MD.0000000000006621
Stania M, Juras G, Chmielewska D, Polak A, Kucio C, Król P. Extracorporeal Shock Wave Therapy for Achilles Tendinopathy. Biomed Res Int. 2019;3086910. DOI: https://doi.org/10.1155/2019/3086910
Feeney KM. The Effectiveness of Extracorporeal Shockwave Therapy for Midportion Achilles Tendinopathy: A Systematic Review. Cureus. 2022;14(7):e26960. DOI: https://doi.org/10.7759/cureus.26960
Yao G, Chen J, Duan Y, Chen X. Efficacy of Extracorporeal Shock Wave Therapy for Lateral Epicondylitis: A Systematic Review and Meta-Analysis. Biomed Res Int. 2020;2064781. DOI: https://doi.org/10.1155/2020/2064781
Charles R, Fang L, Zhu R, Wang J. The effectiveness of shockwave therapy on patellar tendinopathy, Achilles tendinopathy, and plantar fasciitis: a systematic review and meta-analysis. Front Immunol. 2023;14:1193835. DOI: https://doi.org/10.3389/fimmu.2023.1193835
Rompe JD, Furia JP, Maffulli N. Eccentric loading versus eccentric loading plus shock-wave treatment for midportion Achilles tendinopathy. Am J Sports Med. 2009;37(3):463-70. DOI: https://doi.org/10.1177/0363546508326983
Gerdesmeyer L, Frey C, Vester J, Maier M, Weil L Jr, et al. Radial extracorporeal shock wave therapy is safe and effective in the treatment of chronic recalcitrant plantar fasciitis: results of a confirmatory randomized placebo-controlled multicentre study. Am J Sports Med. 2008;36(11):2100-9. DOI: https://doi.org/10.1177/0363546508324176
Speed CA, Nichols D, Richards C, Humphreys H, Wies T, Burnet S, et al. Extracorporeal shock wave therapy for lateral epicondylitis: a double blind randomised controlled trial. J Orthop Res. 2002;20(5):895-8. DOI: https://doi.org/10.1016/S0736-0266(02)00013-X
Zwerver J, Thijs KM, Backx FJ, Steeneken V, Rayer S, Groenenboom P, et al. Effectiveness of Shockwave Treatment Combined With Eccentric Training for Patellar Tendinopathy: A Double-Blinded Randomized Study. Clin J Sport Med. 2017;27(2):89-96. DOI: https://doi.org/10.1097/JSM.0000000000000332
Wang C J. An overview of shock wave therapy in musculoskeletal disorders. Chang Gung Med J. 2003;26(4):220-32.
Romeo P, Lavanga V, Pagani D, Sansone V. Extracorporeal shock wave therapy in musculoskeletal disorders: a review. Med Princ Pract. 2014;23(1):7-13. DOI: https://doi.org/10.1159/000355472
Hausdorf J, Lemmens MA, Heck KD, Grolms N, Korr H, Kertschanska S, et al. Selective loss of unmyelinated nerve fibers after extracorporeal shockwave application to the musculoskeletal system. Neuroscience. 2008;155(1):138-44. DOI: https://doi.org/10.1016/j.neuroscience.2008.03.062
Weihs AW, Fuchs C, Teuschl AH, Hartinger J, Slezak P, Mittermayr R. Shock wave treatment enhances cell proliferation and improves wound healing by ATP release-coupled extracellular signal-regulated kinase (ERK) activation. J Biol Chem. 2014;289(39):27090-104. DOI: https://doi.org/10.1074/jbc.M114.580936
D’Agostino MC, Craig K, Tibalt E, Respizzi S. Shock wave as biological therapeutic tool: from mechanical stimulation to recovery and healing, through mechanotransduction. Int J Surg. 2015;24:147-53. DOI: https://doi.org/10.1016/j.ijsu.2015.11.030
Leal C, Ramon S, Furia J, Fernandez A, Romero, Hernandez-Sierra L. Current concepts of shockwave therapy in chronic patellar tendinopathy. Int J Surg. 2015;24:160-4. DOI: https://doi.org/10.1016/j.ijsu.2015.09.066