A rare case of membranous nephropathy with crescent who responded to intravenous cyclophosphamide

Anshuman Biswal; Sharon Kandari; Chandrashekar Cheluvaiah; Rohit Puri; Arshdeep Singh; Anil Cheriyan; Sandeep Kaur; Abhay Gangdev

doi:10.18203/2320-6012.ijrms20253201

Authors

Anshuman Biswal Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Sharon Kandari Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Chandrashekar Cheluvaiah Department of Nephrology, Aster CMI Hospital, Hebbal Branch, Bengaluru, Karnataka, India
Rohit Puri Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Arshdeep Singh Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Anil Cheriyan Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Sandeep Kaur Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India
Abhay Gangdev Department of Nephrology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20253201

Keywords:

Crescent, Cyclophosphamide, Primary membranous nephropathy, Steroid

Abstract

Crescent formation is a rare complication of primary membranous nephropathy. It is a sign of severe glomerular injury and can lead to rapid deterioration of renal function. Primary membranous nephropathy and crescents have a lower remission rate and poor prognosis. Crescentic transformation can be associated with ANCAs or anti-GBM antibodies. Early detection and prompt management reduces the chances of progression to end stage kidney disease. Authors hereby report a case of primary membranous nephropathy with crescent who had negative ANCA and anti-GBM antibodies who responded to cyclophosphamide and achieved stabilization of GFR.

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