Knee deep in innovation: advancing osteoarthritis therapy through regenerative medicine and precision interventions

Aavrati Rastogi; Roop B. Kalia; Pradeep K. Meena

doi:10.18203/2320-6012.ijrms20253220

Authors

Aavrati Rastogi Department of Orthopaedics, AIIMS, Rishikesh, Uttarakhand, India
Roop B. Kalia Department of Orthopaedics, AIIMS, Rishikesh, Uttarakhand, India https://orcid.org/0000-0002-3418-5942
Pradeep K. Meena Department of Orthopaedics, AIIMS, Rishikesh, Uttarakhand, India https://orcid.org/0000-0001-7278-3671

DOI:

https://doi.org/10.18203/2320-6012.ijrms20253220

Keywords:

Knee osteoarthritis , Osteoarthritis therapy , Non-steroidal anti-inflammatory drugs

Abstract

Knee osteoarthritis (KOA) is a complex, heterogeneous illness that includes abnormal joint remodelling, chronic inflammation, mechanical strain, and metabolic dysregulation. It is not just a disease of cartilage loss. Its increasing prevalence highlights the critical need for disease-modifying approaches beyond palliation, particularly in older and obese individuals.

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References

Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59. DOI: https://doi.org/10.1016/S0140-6736(19)30417-9

Murphy MB, Moncivais K, Caplan AI. Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine. Exp Mol Med. 2013;45(11):e54. DOI: https://doi.org/10.1038/emm.2013.94

Filardo G, Kon E, Di Matteo B, Di Martino A, Merli G, Marcacci M. Platelet-rich plasma for the treatment of knee osteoarthritis: an updated systematic review and meta-analysis. Am J Sports Med. 2021;49(1):195-203.

Gupta PK, Das AK, Chullikana A, Majumdar AS. Efficacy and safety of adult human bone marrow-derived, cultured, pooled, allogeneic MSCs (Stempeucel®): preclinical and clinical trial in osteoarthritis of the knee joint. Arthritis Res Ther. 2016;18(1):301. DOI: https://doi.org/10.1186/s13075-016-1195-7

Mautner K, Malanga GA, Smith J, Shiple B, Sampson S, Bowen JE, et al. A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature. PM R. 2015;7(4 Suppl):S53-9. DOI: https://doi.org/10.1016/j.pmrj.2015.02.005

McIntyre JA, Jones IA, Han B, Vangsness CT Jr. Intra-articular mesenchymal stem cell therapy for the human joint: a systematic review of clinical trials on intra-articular MSC injections. Am J Sports Med. 2018;46(14):3550-63. DOI: https://doi.org/10.1177/0363546517735844

Dell’Isola A, Allan R, Smith SL, Marreiros SS, Steultjens M. Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature. BMC Musculoskelet Disord. 2016;17(1):425. DOI: https://doi.org/10.1186/s12891-016-1286-2

Saxby DJ, Killen BA, Fiedler B, Besier TF, Palanisamy R, Diamond LE. Wearable technology in osteoarthritis: a scoping review. Phys Ther. 2021;101(4):pzab010.

Tiulpin A, Klein S, Bierma-Zeinstra SMA, Thevenot J, Rahtu E, Lehenkari P, et al. Multimodal machine learning-based knee osteoarthritis progression prediction from plain radiographs and clinical data. Sci Rep. 2019;9(1):20038. DOI: https://doi.org/10.1038/s41598-019-56527-3

Kayani B, Konan S, Tahmassebi J, Pietrzak JRT, Haddad FS. Robotic technology in total knee arthroplasty: a review of the literature and future directions. Bone Joint J. 2019;101-B(7):852-60.

Conditt MA, Roche MW. Minimally invasive robotic-arm-guided unicompartmental knee arthroplasty. J Bone Joint Surg Am. 2009;91:63-8. DOI: https://doi.org/10.2106/JBJS.H.01372