Not all hairy cells are the same: a rare case of splenic B-cell lymphoma/leukaemia with prominent nucleoli

Authors

  • Nagarjun Sai Jaine Department of Flow Cytometry, Dr. Lal Path Labs (National Reference Lab), New Delhi, India
  • Beena Chandrasekhar Department of Flow Cytometry, Dr. Lal Path Labs (National Reference Lab), New Delhi, India
  • Kailash Singh Mehra Department of Flow Cytometry, Dr. Lal Path Labs (National Reference Lab), New Delhi, India
  • Sunny Kumar Maurya Department of Flow Cytometry, Dr. Lal Path Labs (National Reference Lab), New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20252519

Keywords:

Rare case , Hairy cells , Splenic B-cell

Abstract

A peripheral blood sample from an 81-year-old male was received at our stand-alone reference laboratory for evaluation in the setting of fever, progressive fatigue over 3 months, and early satiety. On clinical examination, he had significant pallor and a firm, non-tender splenomegaly extending 6 cm below the costal margin. There was no hepatomegaly or lymphadenopathy.

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References

Traverse-Glehen A. Splenic B-cell lymphoma/ leukaemia with prominent nucleoli. In: WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer; 2024. (WHO classification of tumours series, 5th ed.; vol. 11). Available at: https://publications.iarc.who.int/ 637. Accessed on 15th August 2025.

Matutes E, Wotherspoon A, Brito-Babapulle V, Catovsky D. The natural history and clinico-pathological features of the variant form of hairy cell leukemia. Leukemia. 2001;15(1):184-6. DOI: https://doi.org/10.1038/sj.leu.2401999

Paillassa J, Maitre E, Troussard X. Hairy Cell Leukemia (HCL) and HCL Variant: Updates and Spotlights on Therapeutic Advances. Curr Oncol Rep. 2022;24(9):1133-43. DOI: https://doi.org/10.1007/s11912-022-01285-1

Tran J, Gaulin C, Tallman MS. Advances in the Treatment of Hairy Cell Leukemia Variant. Curr Treat Options Oncol. 2022;23(1):99-116. DOI: https://doi.org/10.1007/s11864-021-00927-z

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Published

2025-08-19

How to Cite

Jaine, N. S., Chandrasekhar, B., Mehra, K. S., & Maurya, S. K. (2025). Not all hairy cells are the same: a rare case of splenic B-cell lymphoma/leukaemia with prominent nucleoli. International Journal of Research in Medical Sciences, 13(9), 3935–3936. https://doi.org/10.18203/2320-6012.ijrms20252519

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Section

Letter to the Editor