Nutrient deficiencies in patients with psychiatric disorders – investigating how low levels of omega-3s, B vitamins and magnesium affect mental health conditions like depression, schizophrenia and bipolar disorder

Liza Paul; Palash Kanti Das; Kausar Jahan Aushe; Ahmed Tawhedur Rahaman; Hussein Mohammed Nizamuddin

doi:10.18203/2320-6012.ijrms20253135

Authors

Liza Paul Department of Nutrition and Exercise Science, Southeast Missouri State University, Cape Girardeau, Missouri, USA
Palash Kanti Das Southern Medical College and Hospital, Chattogram, Bangladesh
Kausar Jahan Aushe Mymensingh Medical College, Mymensingh, Bangladesh
Ahmed Tawhedur Rahaman Southern Medical College and Hospital, Chattogram, Bangladesh
Hussein Mohammed Nizamuddin Apollo Imperial Hospitals, Chattogram, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20253135

Keywords:

B vitamins, Bipolar disorder, Nutrient deficiencies, Omega-3s, Psychiatric disorders, Schizophrenia

Abstract

Background: Psychiatric disorders such as depression, schizophrenia and bipolar disorder are complex mental health conditions that significantly affect individuals' quality of life and functional ability. While their etiology is multifactorial, growing evidence suggests that nutritional factors play an important role in the onset and progression of these disorders. This study aims to explore the relationship between deficiencies in omega-3 fatty acids, B vitamins and magnesium and common psychiatric disorders, namely depression, schizophrenia and bipolar disorder.

Methods: This cross-sectional study was conducted from January 2022 to December 2022 at two tertiary care centers in Chattogram, Bangladesh: Chattogram Ma O Shishu Hospital Medical College and BGC Trust Medical College and Hospital. A total of 100 patients diagnosed with psychiatric disorders, including depression, schizophrenia and bipolar disorder, were enrolled from the outpatient and inpatient departments of psychiatry at both institutions. Data were analyzed using SPSS version 25.

Results: In this study, omega-3, B vitamin and magnesium deficiencies were observed in 61%, 58% and 47% of psychiatric patients, respectively. Deficiencies were most common among those with depression (72.9% omega-3, 66.7% B vitamins, 50% magnesium). Patients with longer illness duration (>5 years) showed higher deficiency rates, with 70.8% for omega-3, 79.2% for B vitamins and 62.5% for magnesium. Symptom severity was significantly higher in deficient patients, with mean scores of 26.5, 27.2 and 25.8 for omega-3, B vitamin and magnesium deficiencies, respectively (p<0.05).

Conclusions: This study demonstrates a high prevalence of omega-3 fatty acid, B vitamin and magnesium deficiencies among patients with psychiatric disorders, particularly those with depression and longer illness duration. These deficiencies were significantly associated with greater symptom severity, underscoring the critical role of nutritional status in mental health.

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References

Jaeschke K, Hanna F, Ali S, Chowdhary N, Dua T, Charlson F. Global estimates of service coverage for severe mental disorders: findings from the WHO Mental Health Atlas 2017. Global Men Heal. 2021;8:27. DOI: https://doi.org/10.1017/gmh.2021.30

Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP, et al. Nutritional medicine as mainstream in psychiatry. Lancet Psychiat. 2015;2(3):271-4. DOI: https://doi.org/10.1016/S2215-0366(14)00051-0

Rucklidge JJ, Kaplan BJ. Nutrition and mental health. Clin Psychol Sci. 2016;4(6):1082-4. DOI: https://doi.org/10.1177/2167702616641050

Marx W, Moseley G, Berk M, Jacka F. Nutritional psychiatry: the present state of the evidence. Proceed Nutr Soc. 2017;76(4):427-36. DOI: https://doi.org/10.1017/S0029665117002026

Bazinet RP, Layé S. Polyunsaturated fatty acids and their metabolites in brain function and disease. Nat Rev Neurosci. 2014;15(12):771-85. DOI: https://doi.org/10.1038/nrn3820

Grosso G, Galvano F, Marventano S, Malaguarnera M, Bucolo C, Drago F, et al. Omega‐3 fatty acids and depression: scientific evidence and biological mechanisms. Oxid Med Cell Long. 2014;2(1):313570. DOI: https://doi.org/10.1155/2014/313570

Grosso G, Pajak A, Marventano S, Castellano S, Galvano F, Bucolo C, et al. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PloS one. 2014;9(5):96905. DOI: https://doi.org/10.1371/journal.pone.0096905

Fenton WS, Hibbeln J, Knable M. Essential fatty acids, lipid membrane abnormalities and the diagnosis and treatment of schizophrenia. Biol Psych. 2000;47(1):8-21. DOI: https://doi.org/10.1016/S0006-3223(99)00092-X

McNamara RK, Welge JA. Meta‐analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. Bipolar Disord. 2016;18(3):300-6. DOI: https://doi.org/10.1111/bdi.12386

White DJ, Cox KH, Peters R, Pipingas A, Scholey AB. Effects of four-week supplementation with a multi-vitamin/mineral preparation on mood and blood biomarkers in young adults: A randomised, double-blind, placebo-controlled trial. Nutrients. 2015;7(11):9005-17. DOI: https://doi.org/10.3390/nu7115451

Mikkelsen K, Stojanovska L, Prakash M, Apostolopoulos V. The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas. 2017;96:58-71. DOI: https://doi.org/10.1016/j.maturitas.2016.11.012

Almeida OP, Ford AH, Hirani V, Singh V, McCaul K, Flicker L. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial. The British J Psych. 2014;205(6):450-7. DOI: https://doi.org/10.1192/bjp.bp.114.145177

Ford AH, Flicker L, McCaul K, Van Bockxmeer F, Hegarty S, Hirani V, et al. The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life. Trials. 2010;11:1-8. DOI: https://doi.org/10.1186/1745-6215-11-8

Martins JG. EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J American Coll Nutrit. 2009;28(5):525-42. DOI: https://doi.org/10.1080/07315724.2009.10719785

Amminger GP, Schäfer MR, Papageorgiou K, Klier CM, Cotton SM, Harrigan SM, et al. Long-chain ω-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psych 2010;1;67(2):146-54. DOI: https://doi.org/10.1001/archgenpsychiatry.2009.192

Peet M. Nutrition and schizophrenia: beyond omega-3 fatty acids. Prostaglandins, Leukotrienes and Essential Fatty Acids. 2004;70(4):417-22. DOI: https://doi.org/10.1016/j.plefa.2003.12.019

Bottiglieri T. Homocysteine and folate metabolism in depression. Progr Neuro-Psychopharmacol Biol Psych. 2005;29(7):1103-12. DOI: https://doi.org/10.1016/j.pnpbp.2005.06.021

Miller AL. The methylation, neurotransmitter and antioxidant connections between folate and depression. Altern Med Rev. 2008;2:692-5.

Eby III GA, Eby KL. Magnesium for treatment-resistant depression: a review and hypothesis. Med Hypoth. 2010;74(4):649-60. DOI: https://doi.org/10.1016/j.mehy.2009.10.051

Serefko A, Szopa A, Poleszak E. Magnesium and depression. Magn Ees. 2016;29(3):67.

Wong VW, Ho FY, Shi NK, Sarris J, Ng CH, Tam OK. Lifestyle medicine for anxiety symptoms: A meta-analysis of randomized controlled trials. J Affect Disord. 2022;310:354-68. DOI: https://doi.org/10.1016/j.jad.2022.04.151

Kaplan BJ, Crawford SG, Field CJ, Simpson JS. Vitamins, minerals and mood. Psychological Bullet. 2007;133(5):747. DOI: https://doi.org/10.1037/0033-2909.133.5.747

Jacka FN, O’Neil A, Opie R, Itsiopoulos C, Cotton S, Mohebbi M, et al. A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’trial). BMC Med. 2017;15:1-3. DOI: https://doi.org/10.1186/s12916-017-0791-y