Dermatomyositis associated with malignancy: a case highlighting paraneoplastic syndrome
DOI:
https://doi.org/10.18203/2320-6012.ijrms20252815Keywords:
Dermatomyositis, Malignancy, Paraneoplastic, Syndrome, InflammatoryAbstract
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy characterized by distinctive cutaneous manifestations and progressive, symmetric proximal muscle weakness. It affects both adults and children, with variable clinical presentations and disease severity. The pathogenesis involves autoimmune mechanisms, including complement-mediated microangiopathy, with a potential association with malignancies in adults. In this case study, we report a case of classical DM with incidence of malignancy. Timely diagnosis and administration of steroid led to better prognosis of the patient.
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Gerami P, Schope JM, McDonald L, Walling HW, Sontheimer RD. A systematic review of adult- onset clinically amyopathic dermatomyositis (dermatomyositis sine myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies. J Am Acad Dermatol. 2006;54(4):597-613. DOI: https://doi.org/10.1016/j.jaad.2005.10.041
Dalakas MC. Polymyositis, dermatomyositis and inclusion-body myositis. N Engl J Med. 1991;325(21):1487-98. DOI: https://doi.org/10.1056/NEJM199111213252107
Petri MH, Satoh M, Martin-Marquez BT, Vargas-Ramírez R, Jara LJ, Saavedra MA, et al. Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara. Arthritis Res Ther. 2013;15(2):R48. DOI: https://doi.org/10.1186/ar4207
Salgueiro C, Poblete MJ, Robles-Silva C, Abarzúa Á, Vera-Kellet C. Trichoscopic, oral, and periungual fold findings as activity and damage markers in dermatomyositis patients and their correlation with myositis antibodies. Arch Dermatol Res. 2023;315(6):1603-13. DOI: https://doi.org/10.1007/s00403-023-02554-0
Al Kanaan R, Nazer II, Al Nasser M. A Case of Juvenile Dermatomyositis Presenting with Inverse Gottron’s Papules: A Case Report. Case Rep Dermatol. 2025;17(1):80-5. DOI: https://doi.org/10.1159/000544816
Liluashvili S, Pataraia S, Kituashvili T. Dermoscopic features of connective tissue disease. Dermatol Rev. 2024;111(2):148-52. DOI: https://doi.org/10.5114/dr.2024.142716
Castillo RL, Femia AN. Covert clues: the non-hallmark cutaneous manifestations of dermatomyositis. Ann Translat Med. 2021;9(5):436. DOI: https://doi.org/10.21037/atm-20-5252
McAtee CL, Lubega J, Underbrink K, Curry K, Msaouel P, Barrow M, et al. Association of rituximab use with adverse events in children, adolescents, and young adults. JAMA Network Open. 2021;4(2):2036321. DOI: https://doi.org/10.1001/jamanetworkopen.2020.36321
Ross L, McKelvie P, Reardon K, Wong H, Wicks I, Day J. Muscle biopsy practices in the evaluation of neuromuscular disease: a systematic literature review. Neuropathol Appl Neurobiol. 2023;49(1):12888. DOI: https://doi.org/10.1111/nan.12888
Wu MJ, Liao WA, Lin PY, Sun YT. Muscle biopsy: a requirement for precision medicine in adult-onset myopathy. J Clin Med. 2022;11(6):1580. DOI: https://doi.org/10.3390/jcm11061580
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