Assessment of endothelial dysfunction in diabetes mellitus in Indian population by color Doppler

Abhilash Haridas, Payal Mukker, Sanjay Pandey, Manoj Kumar Parashar, Virender Kumar Mehta


Background: Endothelial dysfunction is regarded as a systemic marker of cardiovascular disease. Brachial artery flow-mediated dilation (FMD) is a mode of evaluating endothelial function and for early diagnosis of atherosclerotic diseases. We studied whether there is a difference in vascular endothelial function between type 1 and 2 diabetes mellitus and normal population.

Methods: We assessed %FMD of 50 patients with diabetes mellitus and 50 control populations without diabetes mellitus or other risk factors. SPSSS version 13 was used for statistical analysis. Students T test was used for comparison of means of the two groups.

Results: The %FMD was significantly lower in patients with type1 and 2 diabetes mellitus compared to normal population.

Conclusions: Diabetes mellitus is associated with endothelial dysfunction irrespective of Type 1 or Type 2 diabetes mellitus, as suggested by impairment in vascular reactivity to hyperemia in both. Monitoring FMD may help in assessment of progression of atherosclerosis.


Diabetes mellitus, Endothelial dysfunction, FMD, Atherosclerosis

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