DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20150266

A study of clinico-demographic profile and ventilatory pulmonary function tests in type 2 diabetes mellitus

Dushyant B. Pawar, Shital D. Pawar, S. D. Zawar, Dilip R. Patil

Abstract


Background: Type 2 Diabetes Mellitus (DM) is a non-communicable disease. DM produces damage in small blood vessels characterized by morphologic and biochemical alterations of the capillary basal lamina. These abnormalities have been observed in several organs including the lung. As the prevalence of diabetes is rapidly increasing, it would be important to study pulmonary functions in this sub group.

Methods: The present observational study carried out at medicine department. It includes previously diagnosed type 2 DM patients between 31 to 50 years of age, non-smoker, non-pregnant with no major respiratory illness. Ventilatory Pulmonary Function Test (VPFT) which includes FVC, FEV1 and FEV1% were studied in all selected participants. VPFT categorized as per American Thoracic Society (ATS). All collected data analysed using Microsoft Excel 2010. 

Results: The total of 55 previously diagnosed Type 2 DM cases was recruited. 26 (47.2 %) & 29 (52.7 %) were male & female respectively. 21 (38.2 %) has duration of DM more than 5. 11 (20 %) & 5 (9 %) had neuropathy and retinopathy respectively. 29 (52.7 %) had abnormal pulmonary function test.  The Mean FVC (84.11 ± 14.94), Mean FEV1 (84 ± 13.72) & Mean FEV1% was (100.05 ± 7.32) among the study participants.  29 (100.0 %) were restrictive type of abnormality.

Conclusion: The reduced lung function is likely being a complication of diabetes mellitus. Lung functions needs to be checked periodically.

 


Keywords


Pulmonary function tests, Clinico-demographic profile, Diabetes mellitus

Full Text:

PDF

References


WHO. Tech Rep Ser. N-916.

Farina J, Furio V, Fernandez-Acenero MJ, Muzas MA. Nodular fibrosis of the Lung in Diabetes Mellitus. Virchows Arch. 1995;427:61-3.

Ljubic S, Metelko Z, Car N, Roglic G, Drazic Z. Reduction of diffusion capacity for carbon monoxide in diabetic patients. Chest. 1998;114:1033-5.

Celik P, Ozmen B, Yorgancioglu A, Ozmen D, Cok G. Pulmonary function parameters in patients with diabetes mellitus. Turk Jour of Endocrin Metab. 1999;(1):5-10.

Schnider SL, Kohn RR. Effects of age and diabetes mellitus on the solubility and non enzymatic glycosylation of human skin collagen. J Clin Invest. 1981; 67: 1630-35.

Pellegrino R et al. Interpretative strategies for lung functions tests. Eur Respir J. 2005;26:948-68.

American Thoracic Society Statement. Snowbird workshop on standardization of spirometry. Am Rev Respir Dis. 1979;119:831-8.

Elvira V, Gabriel J, Luisa D, Alvin P, Myrna B, Joselynna Q. Pulmonary functions in FILIPINO patients with type 2 diabetes mellitus: A Preliminary Study. Phil J Int Med. 2006;44:125-30.

Benbassat CA, Stern E, Kramer M, Lebzelter J, Blum I, Fink G. Pulmonary Function in Patients with Diabetes Mellitus. Am J Med Sci. 2001;322:127-32.

Sinha S, Guleria R, Misra A, Pandey RM, Yadav R, Tiwari S. Pulmonary functions is patients with type 2 diabetes mellitus and Correlation with anthropometry and microvascular complications. Indian J Med Res. 2004;119:66-71.

Jhanwar R et al. Ventilatory pulmonary dysfunction in type 2 diabetes mellitus. JAPI 2002;50:1473.

Pednekar SJ et al. Lung: A Target organ in Diabetes Mellitus. Free Paper Session APICON 2001, JAPI. 2001.

Rahbar S, Blumanfeld O, Ranney HM. Studies of unusual haemoglobin in patients with diabetes mellitus. Biochem Biophys Res Commun. 1969;36:838-45.

Schnack Ch, Festa A, Schwarzmaier D, Assie’a. Pulmonary dysfunction in type 1 diabetes in relation to metabolic long term control and to incipient diabetic nephropathy. Nephron. 1996;74:395-400.

Sharma B, Daga MK, Tiwari N, Kaushik M. Pulmonary Dysfunction in Type 2 Diabetes Mellitus Patients with Incipient Diabetic Nephropathy and Effect of Glycemic Control and Losartan Therapy on Pulmonary Function. Chest. 2003;124(4):162.

Vogt BW, Schleicher ED, Wieland OH. Amino-lysine-bound glucose in human tissues obtained of autopsy. Increase in diabetes mellitus. Diabetes. 1982;31:1123-7.

Sandler M. Is the lung a target organ in diabetes mellitus? Arch Intern Med. 1990;150:1385-8.

Laurent GJ. Lung collagen: More than scaffolding. Thorax. 1986;44:35-40.