Published: 2016-12-18

Prevalence of raised IgE levels and absolute eosinophil count in bronchiolitis in children aged 2 months-2 years in tertiary care hospital

Elango Krishnan, Raja Periyasamy, Sindhu Bharathi


Background: Bronchiolitis is defined by IAP as 'A constellation of clinical symptoms and signs including viral upper respiratory prodrome followed by increased respiratory effort and wheeze in less than 2 year old children'. Aim of the study was to study the prevalence of raised IgE levels and raised Absolute eosinophil count & RSV (respiratory syncytial virus) antigen by PCR in bronchiolitis between age group of 2 months - 2 years with the occurrence of wheeze after first episode in 1 year follow up.

Methods: 96 Children between 2 months - 2 years with first episode of bronchiolitis are included with the exclusion criteria of previous heart disease, lung disease, immune deficiency, second episode of bronchiolitis. In all the children CRP (C reactive protein), IgE (Immunoglobulin E), AEC (Absolute eosinophil count), RSV, PCR was done.

Results: Out of 96 children, 60 children (62%) are males with maximum incidence on subjects of 53 (55.2%) in age group 2-6months. Fever, cough and rhinorrhoea are the major presenting complaints apart from breathlessness. Among 96 children 37 children (38.5%) had high serum IgE out of which 17 developed wheeze in 1 year of follow up. 27 (28.2%) had raisedAEC, out of which 10 had wheeze in follow up. Out of 10 children who had raised IgE andAEC, 3 had wheeze on follow up. 34 (35.4%) children had positive RSVPCR, 14 children had wheeze in follow up.

Conclusions: The prevalence of raised IgE, AEC and RSV PCR are 38.5%, 28.1% and 41.1% and the occurrence of wheeze on follow up was 45.9%, 37% and 41.1% respectively.


Bronchiolitis, IgE, Absolute eosinophil count

Full Text:



Boeck KD. Respiratory syncytial virus bronchiolitis: Clinical aspects and epidemiology. Monaldi Arch Chest Dis. 1996;51(3):210-3.

American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006;118(4):1774-93.

Centers for Disease Control and Prevention. Respiratory syncytial virus activity—United States, July 2011-January 2013. MMWR Morb Mortal Wkly Rep. 2013;62(8):141-4.

Jartti T, Lehtinen P, Vuorinen T. Bronchiolitis age and previous wheezing episode are linked to viral etiology and atopic characteristics, Pediatric infectious Diseases J. 2009;28(4):311-7.

Chattopadhya D, Chatterjee R, Anand VK, Kumari S, Patwari AK. Lower Respiratory tract infection in hospitalised children due to RSV during suspected epidemic period of RSV in Delhi ; J NOP, pediatr. 1992;38(2):68-73.

Lodrup Carlsen KC, Halvorsen R, Carlsen KH. Serum inflammatory markers and effects of age and tobacco smoke exposure in young non asthmatic children. Acta pediatr. 1998;87:559-64.

Gupta S, Shamsundar R, Shet A, Chawan R, Srinivasa H. prevalence of RSV infection among hospitalised children presenting with acute lower respiratory tract infection. Indian J Pediatr. 2011;78(12):1495-7.

Broor S, Parveen S, Bharaj P, Prasad VS, Srinivasulu KN, Sumanth KM, et al A prospective 3 year cohort study of epidemiology and virology of acute respiratory infections of children in rural India. plus one. 2007;6:e 491

Akhtar J, Johani A. epidemiology and diagnosis of human respiratory syncytial virus infections Department of pathology and laboratory medicine, King abdulaziz medical city, Saudi Arabia. Available at: pdfs/24397.pdf

Wang EE, Law BJ, Stephens D. Pediatric investigators collaborative network on infections in canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalised with RSV lower respiratory tract infection J. pediatr. 1995;126(2);212- 9.

Welliver RC, Sun M, Rinaldo D, Ogra PL, Predictive value of RSV specific IgE responses for recurrent wheezing following bronchiolitis. Pediatr. 1986;109;776-80

N siguris, R Bjarnason, B kiellman, B bjorksten, Asthma and IgE antibodies after RSV bronchiolitis; prospective cohort study with matched controls. Pediatrics. 1995;95(4):500-5

Domachowske JB, Rosenberg HF. RSV infection, immune response; immunopathogenesis, and treatment. Clinical microbiology review. 1999;12:298-309.

Scottish Intercollegiate Guidelines Network: Bronchiolitis in children. A national clinical guideline. 2006.