DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20150274

Clear cell adenocarcinoma of the uterine cervix with malignant pleural effusion in a 29-year old female- A case report

Dipti R. Samanta, Chaitali Bose, Saikat Sheet, Ashish Upadhyay, Surendra N. Senapati

Abstract


Primary adenocarcinoma of cervix constitute about 7-15% of all cervical cancer. Clear cell carcinoma, a form of cervical adenocarcinoma is a very rare tumor constituting only 4% of cervical carcinoma. Risk factor and pathogenesis of this disease are not exactly revealed. Intrauterine exposure to diethylstilbestrol and associated non-steroidal estrogen during pregnancy before 18 weeks is the only risk factor. Here we report an unusual case of clear cell carcinoma of cervix presented with bilateral pleural effusion, cytology of which shows adenocarcinoma. This is a rare case since patient had no history of diethylstilbestrol exposure and presented with bilateral pleural effusion. This is the first described case report of clear cell carcinoma of cervix with upfront malignant pleural effusion.


Keywords


Cervix, Clear cell carcinoma, Pleural effusion

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References


Noller KL, Decker DG, Dockerty MB, Lanier AP, Smith RA, Symmonds RE. Mesonephric (clear cell) carcinoma of the vagina and cervix. A retrospective analysis. Obstet Gynecol. 1974;43:640-4.

Crum CP, Nuovo G. The cervix. In: Sternberg SS (ed.). Diagnostic Surgical Pathology, New York: Raven Press, Vol. 2, 1989: 1579-1580.

Herbst AL, Robboy SJ, Scully RE. Clear cell adenocarcinoma of the vagina and cervix in girls: analysis of 170 registry case. Am J Obstet Gynecol. 1974;19:713-24.

Mittendorf R. Teratogen update: carcinogenesis

and teratogenesis associated with exposure to diethylstilbestrol (DES) in utero. Teratology. 1995;51:435-45.

Herbst AL, Robboy SJ, Scully RE, Poskanzer DC. Clear-cell adenocarcinoma of the vagina and cervix in girls: analysis of 170 registry cases. Am J Obstet Gynecol. 1974;119:713-24.

Hanselaar A, van Loosbroek M, Schuurbiers O, Helmerhorst T, Bulten J, Bernhelm J. Clear celladenocarcinoma of the va¬gina and cervix. An update of the central Netherlands reg¬istry showing twin age incidence peaks. Cancer. 1997;79:2229-36.

Herbst AL, Cole P, Norusis WR et al. Epidemiologic aspects and factors related to survival in 384 Registry cases of clear cell adenocarcinoma of the vagina and cervix. Am J Obstet Gynecol. 1979;135:876-86.

Herbst AL. Behaviour of estrogen associated female genital tract cancer and its relation to neoplasia following intrauterine exposure to Diethylstilbestrol (DES). Gynec Oncol. 2000;76:147-56.