Leydig cell tumor of ovary with primary hyperparathyroidism:  A rare association

Suhitha Chittamuri; Mythili Ayyagari; Bhagyalakshmi Atla; Subrahmanyam A.V. Kandregula

doi:10.18203/2320-6012.ijrms20150278

Authors

Suhitha Chittamuri Senior Resident, Department of Endocrinology, Andhra Medical College, Visakhapatnam
Mythili Ayyagari Associate Professor, Department of Endocrinology, Andhra Medical College, Visakhapatnam
Bhagyalakshmi Atla Professor and HOD, Department of Pathology, Andhra Medical College, Visakhapatnam
Subrahmanyam A.V. Kandregula Professor and HOD, Department of Endocrinology, Andhra Medical College, Visakhapatnam

DOI:

https://doi.org/10.18203/2320-6012.ijrms20150278

Keywords:

Leydig cell tumor, Parathyroid adenoma, Virilization

Abstract

Leydig cell tumors of ovary are extremely rare sex cord stromal tumors that account for <0.2% of ovarian cancers. Most of these tumors can cause hyperandrogenism. A 54 year old multiparous postmenopausal woman, known diabetic and hypertensive, presented with progressive virilization, bone pains and depressed mood for 2 years. Diagnostic evaluation revealed markedly elevated testosterone with normal dehydroepiandrosterone sulphate. Computerized tomography of abdomen showed right ovarian mass with multiple cysts in both kidneys. Biochemical investigations revealed hyperglycemia, hypercalcemia, hypophosphatemia and elevated parathormone (PTH) levels. Sestamibi scan for parathyroids was suggestive of right inferior parathyroid adenoma. Histopathology of the resected right ovarian tumor was consistent with leydig cell tumor of ovary. Postoperatively serum testosterone and blood glucose levels were normalized, but PTH levels remained high. PTH levels were normalized after resection of parathyroid adenoma

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